Philippe Tessier studied at Laval University, the John Curtin School of Medical Research (Australian National University) and the University of Adelaide, followed by a post-doctoral fellowship at the Imperial Cancer Research Fund (United Kingdom). He has been a researcher at the Centre de recherche du CHU de Québec – Laval University since 1999, and a professor at the Department of Microbiology-Infectiology and Immunology of the Laval University School of Medicine.

Research Projects

Professor Tessier studies the biological activities of the proteins S100A8 and S100A9, two small proteins expressed by neutrophils, monocytes, and activated endothelial and epithelial cells. These proteins are secreted during inflammation and activate the immune response. His research indicates that S100A8 and S100A9 have opposite functions: S100A8 is anti-inflammatory and inhibits myeloid cell differentiation, while S100A9 is pro-inflammatory and induces the differentiation of precursors of neutrophils and monocytes. He studies the roles of these proteins in autoimmune diseases such as rheumatoid arthritis, psoriasis, and Crohn’s disease, in immune responses to solid tumors, and in the differentiation of leukemia cells.

Auto-inflammatory diseases are monogenic orphan diseases (<10,000 cases per syndrome worldwide) usually caused by defects in the genes regulating innate immunity. These diseases are characterized by recurrent, unprovoked inflammation (fever, abdominal pain, rash, arthralgia). High plasma concentrations of S100A8 and S100A9 are often found in patients with auto-inflammatory diseases. In collaboration with Professor Martin Pelletier and Dr. Anne-Laure Chetaille, Prof. Tessier is currently studying the roles of S100A8 and S100A9 in these diseases, to develop a diagnostic test to facilitate the treatment of these patients.

CHUL
2705, boulevard Laurier
R-0709
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 47607 / 48911+1 418-654-2715
philippe.tessier@crchudeq...

Latest news

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Tardif MR, Chapeton-Montes JA, Posvandzic A, Page N, Gilbert C, Tessier PA

Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux

Journal Article

J Immunol Res, 2015 , 2015.

Abstract | Links:

El Azreq MA, Arseneault C, Boisvert M, Page N, Allaeys I, Poubelle PE, Tessier PA, Aoudjit F

Cooperation between IL-7 Receptor and Integrin α2β1 (CD49b) Drives Th17-Mediated Bone Loss

Journal Article

J Immunol, 195 (9), 2015.

Abstract | Links:

Simard JC, Noel C, Tessier PA, Girard D

Human S100A9 potentiates IL-8 production in response to GM-CSF or fMLP via activation of a different set of transcription factors in neutrophils

Journal Article

FEBS Lett, 588 (13), 2014.

Abstract | Links:

Cormier K, Harquail J, Ouellette RJ, Tessier PA, Guerrette R, Robichaud GA

Intracellular expression of inflammatory proteins S100A8 and S100A9 leads to epithelial-mesenchymal transition and attenuated aggressivity of breast cancer cells

Journal Article

Anticancer Agents Med Chem, 14 (1), 2014.

Abstract | Links:

Tsai SY, Segovia JA, Chang TH, Morris IR, Berton MT, Tessier PA, Tardif MR, Cesaro A, Bose S

DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway

Journal Article

PLoS Pathog, 10 (1), 2014.

Abstract | Links:

Contreras I, Shio MT, Cesaro A, Tessier PA, Olivier M

Impact of neutrophil-secreted myeloid related proteins 8 and 14 (MRP 8/14) on leishmaniasis progression

Journal Article

PLoS Negl Trop Dis, 7 (9), 2013.

Abstract | Links:

El Azreq MA, Boisvert M, Cesaro A, Page N, Loubaki L, Allaeys I, Chakir J, Poubelle PE, Tessier PA, Aoudjit F

α2β1 integrin regulates Th17 cell activity and its neutralization decreases the severity of collagen-induced arthritis

Journal Article

J Immunol, 191 (12), 2013.

Abstract | Links:

Gopal R, Monin L, Torres D, Slight S, Mehra S, McKenna K, Fallert Junecko BA, Reinhart TA, Kolls J, Baez-Saldana R, Cruz-Lagunas A, Rodriguez-Reyna TS, Kumar NP, Tessier P, Roth J, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Cumming B, Kasprowicz VO, Steyn AJ, Babu S, Kaushal D, Zuniga J, Vogl T, Rangel-Moreno J, Khader SA

S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis

Journal Article

Am J Respir Crit Care Med, 188 (9), 2013.

Abstract | Links:

Gagne V, Marois L, Levesque JM, Galarneau H, Lahoud MH, Caminschi I, Naccache PH, Tessier P, Fernandes MJ

Modulation of monosodium urate crystal-induced responses in neutrophils by the myeloid inhibitory C-type lectin-like receptor: potential therapeutic implications

Journal Article

Arthritis Res Ther, 15 (4), 2013.

Abstract | Links:

Simard JC, Cesaro A, Chapeton-Montes J, Tardif M, Antoine F, Girard D, Tessier PA

S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-κB(1.)

Journal Article

PLoS One, 8 (8), 2013.

Abstract | Links:

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Active projects

  • Biology of S100A8 and S100A9 proteins in Human Acute Myeloid Leukemia, from 2019-10-01 to 2024-09-30
  • Developing synthetic S100A9-based molecules for differentiation therapy of human acute myeloid leukemia, from 2022-04-01 to 2027-03-31
  • Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1, from 2021-12-01 to 2025-03-31
Data provided by the Université Laval research projects registery