Philippe Tessier studied at Laval University, the John Curtin School of Medical Research (Australian National University) and the University of Adelaide, followed by a post-doctoral fellowship at the Imperial Cancer Research Fund (United Kingdom). He has been a researcher at the Centre de recherche du CHU de Québec – Laval University since 1999, and a professor at the Department of Microbiology-Infectiology and Immunology of the Laval University School of Medicine.

Research Projects

Professor Tessier studies the biological activities of the proteins S100A8 and S100A9, two small proteins expressed by neutrophils, monocytes, and activated endothelial and epithelial cells. These proteins are secreted during inflammation and activate the immune response. His research indicates that S100A8 and S100A9 have opposite functions: S100A8 is anti-inflammatory and inhibits myeloid cell differentiation, while S100A9 is pro-inflammatory and induces the differentiation of precursors of neutrophils and monocytes. He studies the roles of these proteins in autoimmune diseases such as rheumatoid arthritis, psoriasis, and Crohn’s disease, in immune responses to solid tumors, and in the differentiation of leukemia cells.

Auto-inflammatory diseases are monogenic orphan diseases (<10,000 cases per syndrome worldwide) usually caused by defects in the genes regulating innate immunity. These diseases are characterized by recurrent, unprovoked inflammation (fever, abdominal pain, rash, arthralgia). High plasma concentrations of S100A8 and S100A9 are often found in patients with auto-inflammatory diseases. In collaboration with Professor Martin Pelletier and Dr. Anne-Laure Chetaille, Prof. Tessier is currently studying the roles of S100A8 and S100A9 in these diseases, to develop a diagnostic test to facilitate the treatment of these patients.

CHUL
2705, boulevard Laurier
R-0709
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 47607 / 48911+1 418-654-2715
philippe.tessier@crchudeq...

Latest news

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Jeong H, Kim S, Hong BJ, Lee CJ, Kim YE, Bok S, Oh JM, Gwak SH, Yoo MY, Lee MS, Chung SJ, Defrene J, Tessier P, Pelletier M, Jeon H, Roh TY, Kim B, Kim KH, Ju JH, Lee YJ, Kim DW, Kim IH, Kim HJ, Park JW, Lee YS, Lee JS, Cheon GJ, Weissman IL, Chung DH, Jeon YK, Ahn GO

Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis

Journal Article

Cancer Res, 79 (4), 2019.

Abstract | Links:

Poubelle PE, Page N, Longchamps MP, Sampaio Moura N, Beck DB, Aksentijevich I, Tessier PA, Pelletier M

The use of leukocytes' secretome to individually target biological therapy in autoimmune arthritis: a case report

Journal Article

Clin Transl Med, 8 (1), 2019.

Abstract | Links:

Fujita Y, Khateb A, Li Y, Tinoco R, Zhang T, Bar-Yoseph H, Tam MA, Chowers Y, Sabo E, Gerassy-Vainberg S, Starosvetsky E, James B, Brown K, Shen-Orr SS, Bradley LM, Tessier PA, Ronai ZA

Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis

Journal Article

Cell Rep, 24 (12), 2018.

Abstract | Links:

Pelletier M, Simard JC, Girard D, Tessier PA

Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9

Journal Article

Blood Adv, 2 (10), 2018.

| Links:

Rousseau LS, Pare G, Lachhab A, Naccache PH, Marceau F, Tessier P, Pelletier M, Fernandes M

S100A9 potentiates the activation of neutrophils by the etiological agent of gout, monosodium urate crystals

Journal Article

J Leukoc Biol, 102 (3), 2017.

Abstract | Links:

Joly P, Marshall JC, Tessier PA, Masse C, Page N, Frenette AJ, Khazoom F, Le Guillan S, Berthiaume Y, Charbonney E

S100A8/A9 and sRAGE kinetic after polytrauma; an explorative observational study

Journal Article

Scand J Trauma Resusc Emerg Med, 25 (1), 2017.

Abstract | Links:

Laouedj M, Tardif MR, Gil L, Raquil MA, Lachhab A, Pelletier M, Tessier PA, Barabe F

S100A9 induces differentiation of acute myeloid leukemia cells through TLR4

Journal Article

Blood, 129 (14), 2017.

Abstract | Links:

Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt RW, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization

Journal Article

J Exp Med, 213 (10), 2016.

Abstract | Links:

El Azreq MA, Kadiri M, Boisvert M, Page N, Tessier PA, Aoudjit F

Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway

Journal Article

Oncotarget, 7 (29), 2016.

Abstract | Links:

El Azreq MA, Arseneault C, Boisvert M, Page N, Allaeys I, Poubelle PE, Tessier PA, Aoudjit F

Cooperation between IL-7 Receptor and Integrin α2β1 (CD49b) Drives Th17-Mediated Bone Loss

Journal Article

J Immunol, 195 (9), 2015.

Abstract | Links:

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Active projects

  • Biology of S100A8 and S100A9 proteins in Human Acute Myeloid Leukemia, from 2019-10-01 to 2024-09-30
  • Developing synthetic S100A9-based molecules for differentiation therapy of human acute myeloid leukemia, from 2022-04-01 to 2027-03-31
  • Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1, from 2021-12-01 to 2025-03-31
Data provided by the Université Laval research projects registery