Dr. Paul Isenring has been a Professor of Medicine in the Department of Medicine at Laval University since 2011. He holds a doctorate in medicine, which he obtained in 1986 from Laval University, as well as certificates in internal medicine and nephrology, obtained in 1989 and 1991 from the Collège des médecins du Québec and the Royal College of Physicians and Surgeons of Canada. Upon completing his training in Nephrology, he began graduate studies at Yale University, where he obtained a PhD in molecular physiology in early 1996. He then pursued postdoctoral studies for three years at the same institution before establishing himself as an independent researcher at L’Hôtel-Dieu de Québec’s Research Centre.

Since returning to Quebec, Dr. Isenring has devoted 70% of his time to research, working mainly in the field of applied membrane transport. He is particularly interested in a family of membrane proteins called cation-chloride cotransporters, whose role is to allow the passage of chloride with that of sodium and/or potassium across the cell surface. He is more specifically interested in the molecular determinants that underlie the function, assembly and regulation of these proteins, as well as their roles in the renal tubular epithelium and the cardiovascular system. To achieve his goals, he made use of different heterologous expression systems and animal models, while using directed mutagenesis.

Dr. Isenring has three other fields of interest. He is working to discover new transport systems by characterizing the function of candidate proteins whose role is either unknown or more complex than demonstrated in previous studies. He is also involved in the investigation of various human genetic diseases through the identification of associated mutations as well as in vitro characterization of genetic defects. Finally, Dr. Isenring devotes a part of his time to the care of patients who are suffering from electrolyte disorders and nephrological problems, while also teaching externs and residents of medicine.

The work of Dr. Isenring and his team has led to several discoveries such as the identification of (1) several mechanisms that allow cation-chloride cotransporters to perform both their operational and physiological roles, and to be regulated at the plasma membrane, (2) new functions for different membrane proteins , including that of silicon transport by aquaporins, and (3) unprecedented nosological entities or pathogenic mechanisms hitherto unknown.

L'Hôtel-Dieu de Québec
10, rue McMahon
3853-1
Québec, Québec
Canada G1R 2J6
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Rioux AV, Nsimba-Batomene TR, Slimani S, Bergeron NA, Gravel MA, Schreiber SV, Fiola MJ, Haydock L, Garneau AP, Isenring P

Navigating the Multifaceted Intricacies of the Na+-Cl- cotransporter, a Highly Regulated and Key Effector in the Control of Hydromineral Homeostasis

Journal Article

Physiol Rev, 2024.

Abstract | Links:

Béland MA, Bergeron NAD, Béland M, Haydock L, Isenring P

An unusual complication of arteriovenous fistula

Journal Article

Kidney Int, 105 (4), 2024.

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Thakral V, Sharma Y, Mandlik R, Kumawat S, Patil G, Sonah H, Isenring P, Bélanger R, Sharma TR, Deshmukh R

Identification of VrNIP2-1 aquaporin with novel selective filter regulating the transport of beneficial as well as hazardous metalloids in mungbean (Vigna radiata L.)

Journal Article

Plant Physiol Biochem, 203 , 2023.

Abstract | Links:

Rioux AV, Bergeron NA, Riopel J, Marcoux N, Thériault C, Gould PV, Garneau AP, Isenring P

The ever wider clinical spectrum of RMND1-related disorders and limitedness of phenotype-based classifications

Journal Article

J Mol Med (Berl), 101 (10), 2023.

Abstract | Links:

Connaughton DM, Bhai P, Isenring P, Mahdi M, Sadikovic B, Schenkel LC

Genotypic analysis of a large cohort of patients with suspected atypical hemolytic uremic syndrome

Journal Article

J Mol Med (Berl), 101 (8), 2023.

Abstract | Links:

Haydock L, Garneau AP, Tremblay L, Yen HY, Gao H, Harrisson R, Isenring P

Genetic abnormalities in biopsy-proven, adult-onset hemolytic uremic syndrome and C3 glomerulopathy

Journal Article

J Mol Med (Berl), 100 (2), 2022.

Abstract | Links:

Patriquin CJ, Pavenski K, Garland J, Girard LP, Isenring P

Complement-Amplifying Conditions in Atypical Hemolytic Uremic Syndrome: A Canadian Case Series

Journal Article

Can J Kidney Health Dis, 9 , 2022.

Abstract | Links:

Garneau AP, Haydock L, Tremblay LE, Harvey-Michaud PL, Hsiao YE, Strom SP, Canaud G, Isenring P

Somatic non-cancerous overgrowth syndrome of obscure molecular etiology: what are the causes and options?

Journal Article

J Mol Med (Berl), 100 (7), 2022.

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Quigley N, Garneau AP, Haydock L, Isenring P

Extreme Hyponatremia Complicated by Osmotic Demyelination in a Previously Healthy Young Individual

Journal Article

Can J Kidney Health Dis, 9 , 2022.

Abstract | Links:

Garneau AP, Slimani S, Haydock L, Nsimba-Batomene TR, Préfontaine FCM, Lavoie MM, Tremblay LE, Fiola MJ, Mac-Way F, Isenring P

Molecular mechanisms, physiological roles, and therapeutic implications of ion fluxes in bone cells: Emphasis on the cation-Cl- cotransporters

Journal Article

J Cell Physiol, 237 (12), 2022.

Abstract | Links:

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Active projects

  • Molecular characterization of newly identified silicon transporters in animals, from 2021-04-01 to 2026-03-31
  • Suivis de la thérapeutique d'une maladie rare et de la modification du facteur de risque cardiovasculaire , from 2019-08-09 to 2025-12-25

Recently finished projects

  • Molecular characterization of renal K-Cl cotransporters, from 2020-10-01 to 2022-09-30
  • Molecular characterization of the Na-K-Cl cotransporter 2 (NKCC2) splice variants in the thick ascending loop of Henle, from 2022-03-01 to 2023-02-28
  • Nouveau paradigme du transport de silicium chez les plantes dans un contexte d’une agriculture durable, from 2020-04-01 to 2023-03-31
Data provided by the Université Laval research projects registery