Dr. Patrick Laprise is a regular researcher in the Oncology axis of the CHU of Quebec-Laval University Research Centre. He is also a professor in the Department of Molecular Biology, Medical Biochemistry and Pathology at Laval University. His research activities focus on understanding cell polarity in cancer. Dr. Laprise also uses the fruit fly to highlight new strategies to combat tumor progression and cancer-related complications. His works have been published in prestigious journals and have been the subject of several editorial texts. In addition, two of his discoveries have been identified as major breakthroughs by Faculty of 1000.

Understanding the cellular and molecular basis of tumor progression

The vast majority of cancers originate from epithelial tissues. These cover the surface of the body and lining of the internal cavities of organs in order to compartmentalize the body and protect it from its environment. The epithelial cells adopt an asymmetrical morphology, called epithelial polarity, which is absolutely vital to their function. The loss of epithelial polarity contributes to the invasion of cancer cells and the formation of metastases. These are often responsible for the lethality associated with cancer. The identification of proteins contributing to the loss of polarity and the characterization of their biochemical properties makes it possible to identify therapeutic strategies for combating the progression of cancer.

Use of the fruit fly in the identification of oncology therapies

Cachexia occurs in many cancer patients. This systemic syndrome is characterized by a massive loss of muscle and fat tissue, which causes significant morbidity, and may even lead to death. Our ability to understand cachexia with traditional experimental models is limited because this syndrome is difficult to model with cultured cells. Additionally, it is financially and logistically unthinkable to test thousands of potential drugs in mice. It is possible to induce tumor formation and cachexia in fruit flies. This model offers an exceptional opportunity to screen large-scale molecule libraries to identify chemical compounds that prevent tumor formation, as well as cachexia associated with cancer. Indeed, it is easy, fast and inexpensive to work with flies, compared to mammals.

L'Hôtel-Dieu de Québec
9, rue McMahon
1724-2
Québec, Québec
Canada G1R 2J6
26 entries « 2 of 3 »

Charrier LE, Loie E, Laprise P

Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo

Journal Article

Sci Rep, 5 , 2015.

Abstract | Links:

Sollier K, Gaude HM, Chartier FJ, Laprise P

Rac1 controls epithelial tube length through the apical secretion and polarity pathways

Journal Article

Biol Open, 5 (1), 2015.

Abstract | Links:

Gamblin CL, Hardy EJ, Chartier FJ, Bisson N, Laprise P

A bidirectional antagonism between aPKC and Yurt regulates epithelial cell polarity

Journal Article

J Cell Biol, 204 (4), 2014.

Abstract | Links:

Gareau C, Houssin E, Martel D, Coudert L, Mellaoui S, Huot ME, Laprise P, Mazroui R

Characterization of fragile X mental retardation protein recruitment and dynamics in Drosophila stress granules

Journal Article

PLoS One, 8 (2), 2013.

Abstract | Links:

Chartier FJ, Hardy EJ, Laprise P

Crumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell death

Journal Article

J Cell Biol, 198 (6), 2012.

Abstract | Links:

Laprise P, Tepass U

Novel insights into epithelial polarity proteins in Drosophila

Journal Article

Trends Cell Biol, 21 (7), 2011.

Abstract | Links:

Laprise P

Emerging role for epithelial polarity proteins of the Crumbs family as potential tumor suppressors

Journal Article

J Biomed Biotechnol, 2011 , 2011.

Abstract | Links:

Chartier FJ, Hardy EJ, Laprise P

Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K

Journal Article

J Cell Sci, 124 (Pt 20), 2011.

Abstract | Links:

Laprise P, Paul SM, Boulanger J, Robbins RM, Beitel GJ, Tepass U

Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathway

Journal Article

Curr Biol, 20 (1), 2010.

Abstract | Links:

Laprise P

[Identification of novel polarity proteins revealed the temporal regulation of the epithelial phenotype]

Journal Article

Med Sci (Paris), 26 (1), 2010.

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26 entries « 2 of 3 »
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Active projects

  • Fonds de cancérologie et ses fonds liés, from 2005-04-01 to 2025-04-30
  • Mécanismes moléculaires orchestrant la transition épithélio-mésenchymateuse, from 2023-04-01 to 2026-03-31
  • Molecular mechanisms defining the size of biological tubes in vivo, from 2020-04-01 to 2025-03-31
  • Régulation de la morphogenèse tissulaire par la signalisation dépendante des récepteurs EPH et des ligands éphrines, from 2024-04-01 to 2027-03-31
  • Role and regulation of EPB41L5 in cancer-promoting cellular processes, from 2023-04-01 to 2028-03-31

Recently finished projects

  • Exploration of a novel therapeutic strategy impeding triple-negative breast cancer growth and progression, from 2022-04-01 to 2023-03-31
  • Projet de recherche portant sur l'exploration de nouvelles stratégies thérapeutiques pour combattre les cancers agressifs , from 2022-05-27 to 2023-05-26
Data provided by the Université Laval research projects registery