Dr. Patrick Laprise is a regular researcher in the Oncology axis of the CHU of Quebec-Laval University Research Centre. He is also a professor in the Department of Molecular Biology, Medical Biochemistry and Pathology at Laval University. His research activities focus on understanding cell polarity in cancer. Dr. Laprise also uses the fruit fly to highlight new strategies to combat tumor progression and cancer-related complications. His works have been published in prestigious journals and have been the subject of several editorial texts. In addition, two of his discoveries have been identified as major breakthroughs by Faculty of 1000.
Understanding the cellular and molecular basis of tumor progression
The vast majority of cancers originate from epithelial tissues. These cover the surface of the body and lining of the internal cavities of organs in order to compartmentalize the body and protect it from its environment. The epithelial cells adopt an asymmetrical morphology, called epithelial polarity, which is absolutely vital to their function. The loss of epithelial polarity contributes to the invasion of cancer cells and the formation of metastases. These are often responsible for the lethality associated with cancer. The identification of proteins contributing to the loss of polarity and the characterization of their biochemical properties makes it possible to identify therapeutic strategies for combating the progression of cancer.
Use of the fruit fly in the identification of oncology therapies
Cachexia occurs in many cancer patients. This systemic syndrome is characterized by a massive loss of muscle and fat tissue, which causes significant morbidity, and may even lead to death. Our ability to understand cachexia with traditional experimental models is limited because this syndrome is difficult to model with cultured cells. Additionally, it is financially and logistically unthinkable to test thousands of potential drugs in mice. It is possible to induce tumor formation and cachexia in fruit flies. This model offers an exceptional opportunity to screen large-scale molecule libraries to identify chemical compounds that prevent tumor formation, as well as cachexia associated with cancer. Indeed, it is easy, fast and inexpensive to work with flies, compared to mammals.
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Pak1 and PP2A antagonize aPKC function to support cortical tension induced by the Crumbs-Yurt complexJournal Article
Elife, 10 , 2021.
Girdin is a component of the lateral polarity protein network restricting cell disseminationJournal Article
PLoS Genet, 16 (3), 2020.
Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell deathJournal Article
J Cell Biol, 219 (4), 2020.
A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2Journal Article
Nucleic Acids Res, 47 (14), 2019.
Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling NetworksJournal Article
Mol Cell, 70 (6), 2018.
Oligomerization of the FERM-FA protein Yurt controls epithelial cell polarityJournal Article
J Cell Biol, 217 (11), 2018.
Rac1 controls epithelial tube length through the apical secretion and polarity pathwaysJournal Article
Biol Open, 5 (1), 2015.
Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivoJournal Article
Sci Rep, 5 , 2015.
CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent SignalingJournal Article
Mol Cell Biol, 35 (19), 2015.
Girdin-mediated interactions between cadherin and the actin cytoskeleton are required for epithelial morphogenesis in DrosophilaJournal Article
Development, 142 (10), 2015.
- Exploration of a novel therapeutic strategy impeding triple-negative breast cancer growth and progression, from 2022-04-01 to 2023-03-31
- Molecular mechanisms defining the size of biological tubes in vivo, from 2020-04-01 to 2025-03-31
Recently finished projects
- Analyse protéomique des réseaux de signalisation dépendants des récepteurs tyrosine kinase de la famille EPH et de leurs fonctions dans la ségrégation cellulaire et la polarité épitheliale, from 2018-04-01 to 2021-03-31
- Identification and validation of compounds targeting tumor growth and cancer-induced cachexia, from 2019-09-01 to 2021-08-31
- Mécanismes moléculaires orchestrant la polarité épithéliale, from 2017-07-01 to 2020-06-30
- Molecular mechanisms orchestrating epithelial cell polarity., from 2015-07-01 to 2021-03-31