Patrick Couture received his medical degree from Laval University in Quebec City. He completed his residency in Internal Medicine and a PhD in physiology at Laval University and the University of Montreal before heading to Tufts University in Boston, MA, for a research fellowship at the Jean-Mayer USDA Human Nutrition Research Center on Aging. Upon returning to Quebec City, he joined the CHU Research Center and the Institute of Nutrition and Functional Foods, where he contributed to the establishment of a clinical research center focused on nutrition and lipoprotein metabolism. Dr. Couture is currently a professor in Laval University’s School of Medicine, and he was the director of the university’s residency training program in internal medicine from 2007 to 2012. Dr. Couture is currently the director of the Lipid Apheresis Program at the Laval University Medical Center, and he is also involved in the clinical care of patients with various lipoprotein disorders.

Investigate the impact of dietary fatty acids on lipoprotein metabolism in patients with diabetes

Diabetes and pre-diabetes are metabolic disorders affecting more than 15% of the world’s population. The prevalence of these disorders is currently on the rise, mainly due to the increasingly sedentary lifestyles associated with rising obesity rates and aging of the population. Because diabetes and pre-diabetes are so closely associated with major health problems such as high blood pressure, high blood cholesterol and cardiovascular disease, they have a tremendous impact on society’s healthcare costs. Significant efforts should therefore be dedicated to tackling this problem from a societal perspective. Dr. Couture’s interests in nutrition led him to uncover the effects of various dietary fatty acids on lipoprotein kinetics and on the expression of key genes involved in intestinal lipid metabolism in patients with diabetes and pre-diabetes. His work is funded by grants from the Canadian Institutes of Health Research, Fonds de recherche du Québec (Santé) and industry.

Education & certification


  • MD, Laval University, Québec City.
  • License from the College of Physicians of Quebec (General Practice).
  • License from the Medical Council of Canada (L.M.C.C.).
  • FLEX (The Federation Licensing Examination) certification, New York State.


  • MSc in physiology (molecular endocrinology), Laval University, Québec City. Research Project: Regulation of 17ß-hydroxysteroid dehydrogenase activity in human breast cancer. Supervisors: Drs. Jacques Simard and Fernand Labrie.


  • American Board of Internal Medicine certification.


  • Residency in Internal Medicine (1998-1993) at Laval University and University of Montréal. The Royal College of Physicians and Surgeons of Canada certification (Internal Medicine).
  • License of the College of Physicians of Quebec (Internal Medicine).


  • PhD in physiology, Laval University, Québec City. Research project: Molecular genetics and phenotypic expression of familial hypercholesterolemia and protein C deficiency in French Canadians. Supervisors: Drs. Jacques Simard and Sital Moorjani.


  • Fellowship, Lipid Metabolism Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA. Research project: Genetic polymorphisms associated with variations in plasma lipoproteins and coronary heart disease risk in the Framingham Offspring Study. Supervisors: Drs. Ernst J. Schaefer and Jose Ordovas.
2705, boulevard Laurier
Québec, Québec
Canada G1V 4G2
  • Desjardins, Louis-CharlesMaster student

248 entries « 2 of 25 »

Mutch DM, Lowry DE, Roth M, Sihag J, Hammad SS, Taylor CG, Zahradka P, Connelly PW, West SG, Bowen K, Kris-Etherton PM, Lamarche B, Couture P, Guay V, Jenkins DJA, Eck P, Jones PJH

Polymorphisms in the stearoyl-CoA desaturase gene modify blood glucose response to dietary oils varying in MUFA content in adults with obesity

Journal Article

Br J Nutr, 127 (4), 2022.

Abstract | Links:

Rousseau M, Horne J, Guénard F, de Toro-Martín J, Garneau V, Guay V, Kearney M, Pilon G, Roy D, Couture P, Couillard C, Marette A, Vohl MC

An 8-week freeze-dried blueberry supplement impacts immune-related pathways: a randomized, double-blind placebo-controlled trial

Journal Article

Genes Nutr, 16 (1), 2021.

Abstract | Links:

Bourgeois R, Girard A, Perrot N, Guertin J, Mitchell PL, Couture C, Gotti C, Bourassa S, Poggio P, Mass E, Capoulade R, Scipione CA, Després AA, Couture P, Droit A, Pibarot P, Boffa MB, Thériault S, Koschinsky ML, Mathieu P, Arsenault BJ

A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization

Journal Article

CJC Open, 3 (4), 2021.

Abstract | Links:

Drouin-Chartier JP, Tremblay AJ, Godbout D, Gagnon A, Clavel MA, Clisson M, Arsenault BJ, Pibarot P, Larose É, Couture P

Correlates of Coronary Artery Calcification Prevalence and Severity in Patients With Heterozygous Familial Hypercholesterolemia

Journal Article

CJC Open, 3 (1), 2021.

Abstract | Links:

Roy G, Boucher A, Couture P, Drouin-Chartier JP

Impact of Diet on Plasma Lipids in Individuals with Heterozygous Familial Hypercholesterolemia: A Systematic Review of Randomized Controlled Nutritional Studies

Journal Article

Nutrients, 13 (1), 2021.

Abstract | Links:

Vors C, Rancourt-Bouchard M, Couillard C, Gigleux I, Couture P, Lamarche B

Sex May Modulate the Effects of Combined Polyphenol Extract and L-citrulline Supplementation on Ambulatory Blood Pressure in Adults with Prehypertension: A Randomized Controlled Trial

Journal Article

Nutrients, 13 (2), 2021.

Abstract | Links:

Pearson GJ, Thanassoulis G, Anderson TJ, Barry AR, Couture P, Dayan N, Francis GA, Genest J, Grégoire J, Grover SA, Gupta M, Hegele RA, Lau D, Leiter LA, Leung AA, Lonn E, Mancini GBJ, Manjoo P, McPherson R, Ngui D, Piché ME, Poirier P, Sievenpiper J, Stone J, Ward R, Wray W

2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults

Journal Article

Can J Cardiol, 37 (8), 2021.

Abstract | Links:

Rajendiran E, Lamarche B, She Y, Ramprasath V, Eck P, Brassard D, Gigleux I, Levy E, Tremblay A, Couture P, House JD, Jones PJH, Desmarchelier C

A combination of single nucleotide polymorphisms is associated with the interindividual variability in the blood lipid response to dietary fatty acid consumption in a randomized clinical trial

Journal Article

Am J Clin Nutr, 114 (2), 2021.

Abstract | Links:

Bourgeois R, Devillers R, Perrot N, Despres AA, Boulanger MC, Mitchell PL, Guertin J, Couture P, Boffa MB, Scipione CA, Pibarot P, Koschinsky ML, Mathieu P, Arsenault BJ

Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis

Journal Article

JACC Basic Transl Sci, 5 (9), 2020.

Abstract | Links:

Franck M, de Toro-Martin J, Guenard F, Rudkowska I, Lemieux S, Lamarche B, Couture P, Vohl MC

Prevention of Potential Adverse Metabolic Effects of a Supplementation with Omega-3 Fatty Acids Using a Genetic Score Approach

Journal Article

Lifestyle Genom, 13 (1), 2020.

Abstract | Links:

248 entries « 2 of 25 »
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Active projects

  • Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.1, from 2019-11-01 to 2024-10-31
  • Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.3, from 2019-11-01 to 2024-10-31
  • Institut sur la nutrition et les aliments fonctionnels (INAF), from 2017-04-01 to 2024-03-31
  • L'empreinte métabolomique plasmatique des produits laitiers: un reflet de leur consommation et une fenêtre sur leurs effets cardiométaboliques, from 2022-10-01 to 2024-09-30
  • Mediterranean diet and physical activity: is the whole better than the sum of each part ? Clinical and mechanistic perspectives, from 2018-04-01 to 2024-03-31
  • Role of altered production of branched-chain hydroxy acids (BCHA) in the pathogenesis of type 2 diabetes (T2D) and fatty liver disease and its prevention by BCHA-supplemented yogurt, from 2023-04-01 to 2028-03-31
  • Unravelling the impact of diet on cardiovascular health in heterozygous familial hypercholesterolemia: a metabolomic approach, from 2021-10-01 to 2025-09-30
  • Validation de la mesure d’expression génique unicellulaire à partir d’un échantillon de tissu hépatique chez des sujets avec une suspicion clinique de stéatose hépatique non-alcoolique., from 2022-08-24 to 2023-08-23

Recently finished projects

  • Canada-Wide Human nutrition trialists' network, from 2014-06-01 to 2023-03-31
  • Differential effects of saturated and monounsaturated fatty acids on chylomicron secretion and the expression of key genes that regulate intestinal lipid metabolism in insulin-resistant subjects, from 2019-04-01 to 2022-03-31
  • Indices de qualité nutritionnelle et calcification des artères coronaires dans une cohorte d'individus avec hypercholestérolémie familiale hétérozygote, from 2021-02-02 to 2022-03-31
  • Plant-based dietary patterns and coronary artery calcification in adults with heterozygous familial hypercholesterolemia, from 2021-04-01 to 2022-03-31
  • Qualité nutritionnelle des aliments et déterminants de l'adhésion aux saines habitudes alimentaires, from 2015-12-01 to 2021-09-30
Data provided by the Université Laval research projects registery