Patrick Couture received his medical degree from Laval University in Quebec City. He completed his residency in Internal Medicine and a PhD in physiology at Laval University and the University of Montreal before heading to Tufts University in Boston, MA, for a research fellowship at the Jean-Mayer USDA Human Nutrition Research Center on Aging. Upon returning to Quebec City, he joined the CHU Research Center and the Institute of Nutrition and Functional Foods, where he contributed to the establishment of a clinical research center focused on nutrition and lipoprotein metabolism. Dr. Couture is currently a professor in Laval University’s School of Medicine, and he was the director of the university’s residency training program in internal medicine from 2007 to 2012. Dr. Couture is currently the director of the Lipid Apheresis Program at the Laval University Medical Center, and he is also involved in the clinical care of patients with various lipoprotein disorders.

Investigate the impact of dietary fatty acids on lipoprotein metabolism in patients with diabetes

Diabetes and pre-diabetes are metabolic disorders affecting more than 15% of the world’s population. The prevalence of these disorders is currently on the rise, mainly due to the increasingly sedentary lifestyles associated with rising obesity rates and aging of the population. Because diabetes and pre-diabetes are so closely associated with major health problems such as high blood pressure, high blood cholesterol and cardiovascular disease, they have a tremendous impact on society’s healthcare costs. Significant efforts should therefore be dedicated to tackling this problem from a societal perspective. Dr. Couture’s interests in nutrition led him to uncover the effects of various dietary fatty acids on lipoprotein kinetics and on the expression of key genes involved in intestinal lipid metabolism in patients with diabetes and pre-diabetes. His work is funded by grants from the Canadian Institutes of Health Research, Fonds de recherche du Québec (Santé) and industry.

Education & certification

1987

  • MD, Laval University, Québec City.
  • License from the College of Physicians of Quebec (General Practice).
  • License from the Medical Council of Canada (L.M.C.C.).
  • FLEX (The Federation Licensing Examination) certification, New York State.

1991

  • MSc in physiology (molecular endocrinology), Laval University, Québec City. Research Project: Regulation of 17ß-hydroxysteroid dehydrogenase activity in human breast cancer. Supervisors: Drs. Jacques Simard and Fernand Labrie.

1992

  • American Board of Internal Medicine certification.

1993

  • Residency in Internal Medicine (1998-1993) at Laval University and University of Montréal. The Royal College of Physicians and Surgeons of Canada certification (Internal Medicine).
  • License of the College of Physicians of Quebec (Internal Medicine).

1997

  • PhD in physiology, Laval University, Québec City. Research project: Molecular genetics and phenotypic expression of familial hypercholesterolemia and protein C deficiency in French Canadians. Supervisors: Drs. Jacques Simard and Sital Moorjani.

1997-99

  • Fellowship, Lipid Metabolism Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA. Research project: Genetic polymorphisms associated with variations in plasma lipoproteins and coronary heart disease risk in the Framingham Offspring Study. Supervisors: Drs. Ernst J. Schaefer and Jose Ordovas.
2975 Chemin Saint-Louis
300
Québec, Québec
Canada G1W 1P7
253 entries « 1 of 26 »

Morin-Bernier J, de Toro-Martín J, Barbe V, San-Cristobal R, Lemieux S, Rudkowska I, Couture P, Barbier O, Vohl MC

Corrigendum: Revisiting multi-omics-based predictors of the plasma triglyceride response to an omega-3 fatty acid supplementation

Journal Article

Front Nutr, 11 , 2024.

Abstract | Links:

Morin-Bernier J, de Toro-Martín J, Barbe V, San-Cristobal R, Lemieux S, Rudkowska I, Couture P, Barbier O, Vohl MC

Revisiting multi-omics-based predictors of the plasma triglyceride response to an omega-3 fatty acid supplementation

Journal Article

Front Nutr, 11 , 2024.

Abstract | Links:

Al-Baldawi Z, Brown L, Ruel I, Baass A, Bergeron J, Cermakova L, Couture P, Gaudet D, Francis GA, Hegele RA, Iatan I, Mancini GBJ, McCrindle BW, Ransom T, Sherman MH, McPherson R, Genest J, Brunham LR

Sex differences in the presentation, treatment and outcomes of patients with homozygous familial hypercholesterolemia

Journal Article

J Clin Lipidol, 2024.

Abstract | Links:

Desjardins LC, Brière F, Tremblay AJ, Rancourt-Bouchard M, Drouin-Chartier JP, Corbeil J, Lemelin V, Charest A, Schaefer EJ, Lamarche B, Couture P

Substitution of dietary monounsaturated fatty acids from olive oil for saturated fatty acids from lard increases low-density lipoprotein apolipoprotein B-100 fractional catabolic rate in subjects with dyslipidemia associated with insulin resistance: a randomized controlled trial

Journal Article

Am J Clin Nutr, 2024.

Abstract | Links:

Barbe V, de Toro-Martín J, San-Cristobal R, Garneau V, Pilon G, Couture P, Roy D, Couillard C, Marette A, Vohl MC

A discriminant analysis of plasma metabolomics for the assessment of metabolic responsiveness to red raspberry consumption

Journal Article

Front Nutr, 10 , 2023.

Abstract | Links:

Gauthier E, de Toro-Martín J, Vallée-Marcotte B, Lemieux S, Rudkowska I, Couture P, Vohl MC

Update of a Genetic Risk Score Predictive of the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation in the FAS Study

Journal Article

Nutrients, 15 (5), 2023.

Abstract | Links:

Dessureault L, Roy G, Couture P, Gangloff A, Guasch-Ferré M, Pérusse L, Tremblay A, Drouin-Chartier JP

Relationship between lifestyle habits and cardiovascular risk factors in familial hypercholesterolemia

Journal Article

Nutr Metab Cardiovasc Dis, 33 (10), 2023.

Abstract | Links:

Franck M, de Toro-Martín J, V Varin T, Garneau V, Pilon G, Roy D, Couture P, Couillard C, Marette A, Vohl MC

Gut Microbial Signatures of Distinct Trimethylamine N-Oxide Response to Raspberry Consumption

Journal Article

Nutrients, 14 (8), 2022.

Abstract | Links:

Keathley J, Kearney M, Garneau V, Toro-Martín J, Varin TV, Pilon G, Couture P, Marette A, Vohl MC, Couillard C

Changes in systolic blood pressure, postprandial glucose, and gut microbial composition following mango consumption in individuals with overweight and obesity

Journal Article

Appl Physiol Nutr Metab, 47 (5), 2022.

Abstract | Links:

Franck M, de Toro-Martín J, Varin TV, Garneau V, Pilon G, Roy D, Couture P, Couillard C, Marette A, Vohl MC

Raspberry consumption: identification of distinct immune-metabolic response profiles by whole blood transcriptome profiling

Journal Article

J Nutr Biochem, 101 , 2022.

Abstract | Links:

253 entries « 1 of 26 »
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Active projects

  • A 2x2 factorial randomized controlled trial to elucidate how ultra-processed foods modulate cardiometabolic risk, from 2024-04-01 to 2028-03-31
  • Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.1, from 2019-11-01 to 2024-10-31
  • Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.3, from 2019-11-01 to 2024-10-31
  • L'empreinte métabolomique plasmatique des produits laitiers: un reflet de leur consommation et une fenêtre sur leurs effets cardiométaboliques, from 2023-01-01 to 2025-09-03
  • Role of altered production of branched-chain hydroxy acids (BCHA) in the pathogenesis of type 2 diabetes (T2D) and fatty liver disease and its prevention by BCHA-supplemented yogurt, from 2023-04-01 to 2028-03-31
  • Unravelling the impact of diet on cardiovascular health in heterozygous familial hypercholesterolemia: a metabolomic approach, from 2021-10-01 to 2025-09-30
  • Validation de la mesure d’expression génique unicellulaire à partir d’un échantillon de tissu hépatique chez des sujets avec une suspicion clinique de stéatose hépatique non-alcoolique., from 2022-08-24 to 2025-03-31

Recently finished projects

  • Canada-Wide Human nutrition trialists' network, from 2014-06-01 to 2023-03-31
  • Institut sur la nutrition et les aliments fonctionnels (INAF), from 2017-04-01 to 2024-03-31
  • Mediterranean diet and physical activity: is the whole better than the sum of each part ? Clinical and mechanistic perspectives, from 2018-04-01 to 2024-03-31
Data provided by the Université Laval research projects registery