Patrick Couture received his medical degree from Laval University in Quebec City. He completed his residency in Internal Medicine and a PhD in physiology at Laval University and the University of Montreal before heading to Tufts University in Boston, MA, for a research fellowship at the Jean-Mayer USDA Human Nutrition Research Center on Aging. Upon returning to Quebec City, he joined the CHU Research Center and the Institute of Nutrition and Functional Foods, where he contributed to the establishment of a clinical research center focused on nutrition and lipoprotein metabolism. Dr. Couture is currently a professor in Laval University’s School of Medicine, and he was the director of the university’s residency training program in internal medicine from 2007 to 2012. Dr. Couture is currently the director of the Lipid Apheresis Program at the Laval University Medical Center, and he is also involved in the clinical care of patients with various lipoprotein disorders.
Investigate the impact of dietary fatty acids on lipoprotein metabolism in patients with diabetes
Diabetes and pre-diabetes are metabolic disorders affecting more than 15% of the world’s population. The prevalence of these disorders is currently on the rise, mainly due to the increasingly sedentary lifestyles associated with rising obesity rates and aging of the population. Because diabetes and pre-diabetes are so closely associated with major health problems such as high blood pressure, high blood cholesterol and cardiovascular disease, they have a tremendous impact on society’s healthcare costs. Significant efforts should therefore be dedicated to tackling this problem from a societal perspective. Dr. Couture’s interests in nutrition led him to uncover the effects of various dietary fatty acids on lipoprotein kinetics and on the expression of key genes involved in intestinal lipid metabolism in patients with diabetes and pre-diabetes. His work is funded by grants from the Canadian Institutes of Health Research, Fonds de recherche du Québec (Santé) and industry.
Education & certification
1987
- MD, Laval University, Québec City.
- License from the College of Physicians of Quebec (General Practice).
- License from the Medical Council of Canada (L.M.C.C.).
- FLEX (The Federation Licensing Examination) certification, New York State.
1991
- MSc in physiology (molecular endocrinology), Laval University, Québec City. Research Project: Regulation of 17ß-hydroxysteroid dehydrogenase activity in human breast cancer. Supervisors: Drs. Jacques Simard and Fernand Labrie.
1992
- American Board of Internal Medicine certification.
1993
- Residency in Internal Medicine (1998-1993) at Laval University and University of Montréal. The Royal College of Physicians and Surgeons of Canada certification (Internal Medicine).
- License of the College of Physicians of Quebec (Internal Medicine).
1997
- PhD in physiology, Laval University, Québec City. Research project: Molecular genetics and phenotypic expression of familial hypercholesterolemia and protein C deficiency in French Canadians. Supervisors: Drs. Jacques Simard and Sital Moorjani.
1997-99
- Fellowship, Lipid Metabolism Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA. Research project: Genetic polymorphisms associated with variations in plasma lipoproteins and coronary heart disease risk in the Framingham Offspring Study. Supervisors: Drs. Ernst J. Schaefer and Jose Ordovas.
300
Québec, Québec
Canada G1W 1P7
Latest news
- Les IRSC investissent 7,6 M$ pour 9 projets de recherche du CRCHU 2019-01-28
- Deux suppléments font chou blanc : Des extraits de raisin et de curcuma ne parviennent pas à contrer l’inflammation qui suit un repas riche en gras 2018-03-29
- Le coeur penche pour le DHA : Une étude met en lumière l’apport spécifique de cet oméga-3 contre les maladies cardiométaboliques 2016-05-05
- Desjardins, ClémenceDoctoral studentCHUL+1 418-525-4444, extension 42296clemence.desjardins@crchudequebec.ulaval.ca
2705, boulevard Laurier
R-4720
Québec, QC
Canada G1V 4G2 - Desjardins, Louis-CharlesDoctoral student
- Tremblay, AndréEmployeeCHUL+1 418-525-4444, extension 42106+1 418-654-2145andre.tremblay@crchudequebec.ulaval.ca
2705, boulevard Laurier
Québec, QC
Canada G1V 4G2
Variance in the composition and number of VLDL and LDL particles with increasing triglyceride or increasing ApoB concentrations
Journal ArticleJ Clin Lipidol, 2024.
Prevention and Management of Cardiovascular Disease in Primary Care: A Comment on the PEER Simplified Lipid Guideline
Journal ArticleCJC Open, 6 (10), 2024.
Sex differences in the presentation, treatment and outcomes of patients with homozygous familial hypercholesterolemia
Journal ArticleJ Clin Lipidol, 18 (2), 2024.
Revisiting multi-omics-based predictors of the plasma triglyceride response to an omega-3 fatty acid supplementation
Journal ArticleFront Nutr, 11 , 2024.
Corrigendum: Revisiting multi-omics-based predictors of the plasma triglyceride response to an omega-3 fatty acid supplementation
Journal ArticleFront Nutr, 11 , 2024.
Substitution of dietary monounsaturated fatty acids from olive oil for saturated fatty acids from lard increases low-density lipoprotein apolipoprotein B-100 fractional catabolic rate in subjects with dyslipidemia associated with insulin resistance: a randomized controlled trial
Journal ArticleAm J Clin Nutr, 119 (5), 2024.
Homozygous Familial Hypercholesterolemia in Canada
Journal ArticleJACC: Advances, 2 (3), 2023.
Update of a Genetic Risk Score Predictive of the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation in the FAS Study
Journal ArticleNutrients, 15 (5), 2023.
A discriminant analysis of plasma metabolomics for the assessment of metabolic responsiveness to red raspberry consumption
Journal ArticleFront Nutr, 10 , 2023.
Design, Rationale, and Preliminary Results of the Canadian Homozygous Familial Hypercholesterolemia Registry: 2008 to 2022 Update
Journal ArticleCanadian journal of health technologies, 3 (2), 2023.
Active projects
- A 2x2 factorial randomized controlled trial to elucidate how ultra-processed foods modulate cardiometabolic risk, from 2024-04-01 to 2028-03-31
- Institut sur la nutrition et les aliments fonctionnels (INAF), from 2024-04-01 to 2030-03-31
- L'empreinte métabolomique plasmatique des produits laitiers: un reflet de leur consommation et une fenêtre sur leurs effets cardiométaboliques, from 2023-01-01 to 2025-10-01
- L’équilibre occupationnel est-il un facteur à prendre en considération dans les habitudes de vie des personnes à risque de maladie cardiovasculaire? : une étude exploratoire, from 2024-04-05 to 2025-03-31
- Role of altered production of branched-chain hydroxy acids (BCHA) in the pathogenesis of type 2 diabetes (T2D) and fatty liver disease and its prevention by BCHA-supplemented yogurt, from 2023-04-01 to 2028-03-31
- Unravelling the impact of diet on cardiovascular health in heterozygous familial hypercholesterolemia: a metabolomic approach, from 2021-10-01 to 2025-09-30
- Validation de la mesure d’expression génique unicellulaire à partir d’un échantillon de tissu hépatique chez des sujets avec une suspicion clinique de stéatose hépatique non-alcoolique., from 2022-08-24 to 2025-03-31
Recently finished projects
- Canada-Wide Human nutrition trialists' network, from 2014-06-01 to 2023-03-31
- Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.1, from 2019-11-01 to 2024-10-31
- Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.3, from 2019-11-01 to 2024-10-31
- Institut sur la nutrition et les aliments fonctionnels (INAF), from 2017-04-01 to 2024-03-31
- Mediterranean diet and physical activity: is the whole better than the sum of each part ? Clinical and mechanistic perspectives, from 2018-04-01 to 2024-03-31