Dr. Dupré is a neurologist at the CHU de Québec-Laval University, a Full Professor in the Department of Medicine of the School of Medicine (Laval University), and the Director of the Neuromuscular and Neurogenetic Disease Clinic of the CHU de Québec – Université Laval.
Dr. Dupré completed his medical training at McGill University and his residency in neurology at Laval University. He completed his postdoctoral training at the Montreal Neurological Hospital and Institute and at Harvard University. In 2007, he discovered a gene (syne-1) implicated in a new form of hereditary ataxia that has since been highly recognized internationally. Dr. Dupré also played an important role in the discovery of the involvement of the TARDBP in the etiology of amyotrophic lateral sclerosis. He is now involved in several provincial, national, and international networks that contribute to the discovery of genes involved in neurological diseases. He has generated more than 100 original publications. Dr. Dupré’s remarkable achievements have earned him several awards, including the 2015 Quebec Society of Muscular Dystrophy Award – ALS component – related to his involvement in the Clinic for Neuromuscular and Neurogenetic Diseases.
The research component of the clinic has grown significantly in recent years, with the creation of the Québec Parkinson Network (rpq-qpn.ca). The network connects clinicians with basic science researchers in the field, giving access to a registry of nearly 1000 patients. In addition to his clinical program, Dr. Dupré is involved in research projects linking clinical and basic research. This is done in collaboration with Dr. François Gros-Louis, of the LOEX research center at CHU de Québec – Laval University. One of these projects aims to discover biomarkers of amyotrophic lateral sclerosis in the skin. Another important project Dr. Dupré takes part in focuses on the development of a reconstructed skin model to study neurofibromatosis. Finally, Dr. Dupré is actively collaborating with Dr. Gros-Louis to identify pathogenic mechanisms of intracranial aneurysms in the Inuit and French-Canadian populations and to develop in vitro models of the disease. This project has just been funded by CIHR for a duration of 5 years.
Département des sciences neurologiques
Canada G1J 1Z4
- [ULaval Nouvelles] COVID-19: des effets persistants sur le goût et l’odorat chez le tiers des personnes infectées 2022-05-30
- [Le Soleil] Premières lignes directrices canadiennes pour la prise en charge de la SLA 2020-11-18
- [Radio-Canada] COVID-19 et perte d’odorat sous la loupe des chercheurs du CHU de Québec 2020-09-01
- Blais, MathieuEmployeeHôpital de l'Enfant-Jésus+1 418-990-8255, extension firstname.lastname@example.orgMATHIEU.BLAIS@crchudequebec.ulaval.ca
1401 18e Rue
LOEX / CMDGT
Ville de Québec, QC
Canada G1J 1Z4
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Chemosensory Dysfunctions Induced by COVID-19 Can Persist up to 7 Months: A Study of Over 700 Healthcare WorkersJournal Article
Chem Senses, 46 , 2021.
The Canadian Neuromuscular Disease Registry 2010-2019: A Decade of Facilitating Clinical Research Througha Nationwide, Pan-NeuromuscularDisease RegistryJournal Article
J Neuromuscul Dis, 8 (1), 2021.
Biofabrication of a three dimensional human-based personalized neurofibroma modelJournal Article
Biotechnol J, 16 (6), 2021.
Evidence for Non-Mendelian Inheritance in Spastic Paraplegia 7Journal Article
Mov Disord, 36 (7), 2021.
Analysis of Heterozygous PRKN Variants and Copy-Number Variations in Parkinson's DiseaseJournal Article
Mov Disord, 36 (1), 2021.
Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's diseaseJournal Article
Neurobiol Aging, 100 , 2021.
GCH1 mutations in hereditary spastic paraplegiaJournal Article
Clin Genet, 100 (1), 2021.
Genetic and Epidemiological Study of Adult Ataxia and Spastic Paraplegia in Eastern QuebecJournal Article
Can J Neurol Sci, 48 (5), 2021.
Targeted sequencing of Parkinson's disease loci genes highlights SYT11, FGF20 and other associationsJournal Article
Brain, 144 (2), 2021.
Assessing non-Mendelian inheritance in inherited axonopathiesJournal Article
Genet Med, 22 (12), 2020.
- Comprehensive Analysis Platform To Understand,Remedy and Eliminate ALS, from 2021-01-01 to 2025-03-31
- Creating an Open Science Repository of ARCA1 iPSCs, from 2021-05-31 to 2023-05-31
- Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models, from 2023-03-01 to 2024-02-29
- Développement d’une approche en santé durable pour la recherche sur le Parkinson et les troubles associés, from 2022-04-29 to 2023-04-30
- Reseau Parkinson Québec_RPQ / Quebec Parkinson, from 2022-04-01 to 2023-03-31
- The Canadian Parkinson Network, from 2018-10-01 to 2023-09-30
Recently finished projects
- Capture ALS - Time Frame, from 2021-10-28 to 2022-10-27
- Creating an Open Science Repository of ARSACS hiPSCs, from 2020-10-23 to 2021-10-22
- Crosstalk between immune response and metabolic signaling: targeting leptin/AMPK axis to restore metabolic homeostasis in ALS, from 2021-02-01 to 2023-01-31
- Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, from 2017-04-01 to 2022-03-31
- Projet 2016-2792 pour les activités de recrutement, from 2019-04-04 to 2021-03-31