Dr. Dupré is a neurologist at the CHU de Québec-Laval University, a Full Professor in the Department of Medicine of the School of Medicine (Laval University), and the Director of the Neuromuscular and Neurogenetic Disease Clinic of the CHU de Québec – Université Laval.

Dr. Dupré completed his medical training at McGill University and his residency in neurology at Laval University. He completed his postdoctoral training at the Montreal Neurological Hospital and Institute and at Harvard University. In 2007, he discovered a gene (syne-1) implicated in a new form of hereditary ataxia that has since been highly recognized internationally. Dr. Dupré also played an important role in the discovery of the involvement of the TARDBP in the etiology of amyotrophic lateral sclerosis. He is now involved in several provincial, national, and international networks that contribute to the discovery of genes involved in neurological diseases. He has generated more than 100 original publications. Dr. Dupré’s remarkable achievements have earned him several awards, including the 2015 Quebec Society of Muscular Dystrophy Award – ALS component – related to his involvement in the Clinic for Neuromuscular and Neurogenetic Diseases.

The research component of the clinic has grown significantly in recent years, with the creation of the Québec Parkinson Network (rpq-qpn.ca). The network connects clinicians with basic science researchers in the field, giving access to a registry of nearly 1000 patients. In addition to his clinical program, Dr. Dupré is involved in research projects linking clinical and basic research. This is done in collaboration with Dr. François Gros-Louis, of the LOEX research center at CHU de Québec – Laval University. One of these projects aims to discover biomarkers of amyotrophic lateral sclerosis in the skin. Another important project Dr. Dupré takes part in focuses on the development of a reconstructed skin model to study neurofibromatosis. Finally, Dr. Dupré is actively collaborating with Dr. Gros-Louis to identify pathogenic mechanisms of intracranial aneurysms in the Inuit and French-Canadian populations and to develop in vitro models of the disease. This project has just been funded by CIHR for a duration of 5 years.

1401, 18e Rue
Département des sciences neurologiques
Québec, Québec
Canada G1J 1Z4
+1 418-649-0252, extension 63177
+1 418-649-5915
nicolas.dupre@chudequebec... nicolas.dupre@crchudequeb...

Latest news

149 entries « ‹ 3 of 15 › »

Bussière N, Mei J, Lévesque-Boissonneault C, Blais M, Carazo S, Gros-Louis F, De Serres G, Dupré N, Frasnelli J

Chemosensory Dysfunctions Induced by COVID-19 Can Persist up to 7 Months: A Study of Over 700 Healthcare Workers

Journal Article

Chem Senses, 46 , 2021.

Abstract | Links:

Hodgkinson V, Lounsberry J, M'Dahoma S, Russell A, Jewett G, Benstead T, Brais B, Campbell C, Johnston W, Lochmüller H, McCormick A, Nguyen CT, O'Ferrall E, Oskoui M, Abrahao A, Briemberg H, Bourque PR, Botez S, Cashman N, Chapman K, Chrestian N, Crone M, Dobrowolski P, Dojeiji S, Dowling JJ, Dupré N, Genge A, Gonorazky H, Grant I, Hasal S, Izenberg A, Kalra S, Katzberg H, Krieger C, Leung E, Linassi G, Mackenzie A, Mah JK, Marrero A, Massie R, Matte G, McAdam L, McMillan H, Melanson M, Mezei MM, O'Connell C, Pfeffer G, Phan C, Plamondon S, Poulin C, Rodrigue X, Schellenberg K, Selby K, Sheriko J, Shoesmith C, Smith RG, Taillon M, Taylor S, Venance S, Warman-Chardon J, Worley S, Zinman L, Korngut L

The Canadian Neuromuscular Disease Registry 2010-2019: A Decade of Facilitating Clinical Research Througha Nationwide, Pan-NeuromuscularDisease Registry

Journal Article

J Neuromuscul Dis, 8 (1), 2021.

Abstract | Links:

Roy V, Lamontagne R, Talagas M, Touzel-Deschenes L, Khuong HT, Saikali S, Dupre N, Gros-Louis F

Biofabrication of a three dimensional human-based personalized neurofibroma model

Journal Article

Biotechnol J, 16 (6), 2021.

Abstract | Links:

Estiar MA, Yu E, Haj Salem I, Ross JP, Mufti K, Akcimen F, Leveille E, Spiegelman D, Ruskey JA, Asayesh F, Dagher A, Yoon G, Tarnopolsky M, Boycott KM, Dupre N, Dion PA, Suchowersky O, Trempe JF, Rouleau GA, Gan-Or Z

Evidence for Non-Mendelian Inheritance in Spastic Paraplegia 7

Journal Article

Mov Disord, 36 (7), 2021.

Abstract | Links:

Yu E, Rudakou U, Krohn L, Mufti K, Ruskey JA, Asayesh F, Estiar MA, Spiegelman D, Surface M, Fahn S, Waters CH, Greenbaum L, Espay AJ, Dauvilliers Y, Dupré N, Rouleau GA, Hassin-Baer S, Fon EA, Alcalay RN, Gan-Or Z

Analysis of Heterozygous PRKN Variants and Copy-Number Variations in Parkinson's Disease

Journal Article

Mov Disord, 36 (1), 2021.

Abstract | Links:

Saini P, Rudakou U, Yu E, Ruskey JA, Asayesh F, Laurent SB, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Greenbaum L, Hassin-Baer S, Espay AJ, Rouleau GA, Alcalay RN, Fon EA, Postuma RB, Gan-Or Z

Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease

Journal Article

Neurobiol Aging, 100 , 2021.

Abstract | Links:

Varghaei P, Yoon G, Estiar MA, Veyron S, Leveille E, Dupré N, Trempe JF, Rouleau GA, Gan-Or Z

GCH1 mutations in hereditary spastic paraplegia

Journal Article

Clin Genet, 100 (1), 2021.

Abstract | Links:

Haj Salem I, Beaudin M, Stumpf M, Estiar MA, Côté PO, Brunet F, Gamache PL, Rouleau GA, Mourabit-Amari K, Gan-Or Z, Dupré N

Genetic and Epidemiological Study of Adult Ataxia and Spastic Paraplegia in Eastern Quebec

Journal Article

Can J Neurol Sci, 48 (5), 2021.

Abstract | Links:

Rudakou U, Yu E, Krohn L, Ruskey JA, Asayesh F, Dauvilliers Y, Spiegelman D, Greenbaum L, Fahn S, Waters CH, Dupré N, Rouleau GA, Hassin-Baer S, Fon EA, Alcalay RN, Gan-Or Z

Targeted sequencing of Parkinson's disease loci genes highlights SYT11, FGF20 and other associations

Journal Article

Brain, 144 (2), 2021.

Abstract | Links:

Bis-Brewer DM, Gan-Or Z, Sleiman P, , Hakonarson H, Fazal S, Courel S, Cintra V, Tao F, Estiar MA, Tarnopolsky M, Boycott KM, Yoon G, Suchowersky O, Dupré N, Cheng A, Lloyd TE, Rouleau G, Schüle R, Züchner S

Assessing non-Mendelian inheritance in inherited axonopathies

Journal Article

Genet Med, 22 (12), 2020.

Abstract | Links:

149 entries « ‹ 3 of 15 › »
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Active projects

  • Comprehensive Analysis Platform To Understand,Remedy and Eliminate ALS, from 2021-01-01 to 2025-03-31
  • Creating an Open Science Repository of ARCA1 iPSCs, from 2021-05-31 to 2023-05-31
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models, from 2023-03-01 to 2024-02-29
  • Développement d’une approche en santé durable pour la recherche sur le Parkinson et les troubles associés, from 2022-04-29 to 2023-04-30
  • Reseau Parkinson Québec_RPQ / Quebec Parkinson, from 2022-04-01 to 2023-03-31
  • The Canadian Parkinson Network, from 2018-10-01 to 2023-09-30

Recently finished projects

  • Capture ALS - Time Frame, from 2021-10-28 to 2022-10-27
  • Creating an Open Science Repository of ARSACS hiPSCs, from 2020-10-23 to 2021-10-22
  • Crosstalk between immune response and metabolic signaling: targeting leptin/AMPK axis to restore metabolic homeostasis in ALS, from 2021-02-01 to 2023-01-31
  • Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, from 2017-04-01 to 2022-03-31
  • Projet 2016-2792 pour les activités de recrutement, from 2019-04-04 to 2021-03-31
Data provided by the Université Laval research projects registery