Dr. Dupré is a neurologist at the CHU de Québec-Laval University, a Full Professor in the Department of Medicine of the School of Medicine (Laval University), and the Director of the Neuromuscular and Neurogenetic Disease Clinic of the CHU de Québec – Université Laval.

Dr. Dupré completed his medical training at McGill University and his residency in neurology at Laval University. He completed his postdoctoral training at the Montreal Neurological Hospital and Institute and at Harvard University. In 2007, he discovered a gene (syne-1) implicated in a new form of hereditary ataxia that has since been highly recognized internationally. Dr. Dupré also played an important role in the discovery of the involvement of the TARDBP in the etiology of amyotrophic lateral sclerosis. He is now involved in several provincial, national, and international networks that contribute to the discovery of genes involved in neurological diseases. He has generated more than 100 original publications. Dr. Dupré’s remarkable achievements have earned him several awards, including the 2015 Quebec Society of Muscular Dystrophy Award – ALS component – related to his involvement in the Clinic for Neuromuscular and Neurogenetic Diseases.

The research component of the clinic has grown significantly in recent years, with the creation of the Québec Parkinson Network (rpq-qpn.ca). The network connects clinicians with basic science researchers in the field, giving access to a registry of nearly 1000 patients. In addition to his clinical program, Dr. Dupré is involved in research projects linking clinical and basic research. This is done in collaboration with Dr. François Gros-Louis, of the LOEX research center at CHU de Québec – Laval University. One of these projects aims to discover biomarkers of amyotrophic lateral sclerosis in the skin. Another important project Dr. Dupré takes part in focuses on the development of a reconstructed skin model to study neurofibromatosis. Finally, Dr. Dupré is actively collaborating with Dr. Gros-Louis to identify pathogenic mechanisms of intracranial aneurysms in the Inuit and French-Canadian populations and to develop in vitro models of the disease. This project has just been funded by CIHR for a duration of 5 years.

1401, 18e Rue
Département des sciences neurologiques
Québec, Québec
Canada G1J 1Z4
+1 418-649-0252, extension 63177
+1 418-649-5915
nicolas.dupre@chudequebec... nicolas.dupre@crchudequeb...

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Varghaei P, Estiar MA, Ashtiani S, Veyron S, Mufti K, Leveille E, Yu E, Spiegelman D, Rioux MF, Yoon G, Tarnopolsky M, Boycott KM, Dupre N, Suchowersky O, Trempe JF, Rouleau GA, Gan-Or Z

Genetic, structural and clinical analysis of spastic paraplegia 4

Journal Article

Parkinsonism Relat Disord, 98 , 2022.

Abstract | Links:

Beaudin M, Manto M, Schmahmann JD, Pandolfo M, Dupre N

Recessive cerebellar and afferent ataxias - clinical challenges and future directions

Journal Article

Nat Rev Neurol, 18 (5), 2022.

Abstract | Links:

Giguère-Rancourt A, Plourde M, Racine E, Couture M, Langlois M, Dupré N, Simard M

Goal management training and psychoeducation / mindfulness for treatment of executive dysfunction in Parkinson's disease: A feasibility pilot trial

Journal Article

PLoS One, 17 (2), 2022.

Abstract | Links:

Beaudin M, Salachas F, Pradat PF, Dupré N

Environmental risk factors for amyotrophic lateral sclerosis: a case-control study in Canada and France

Journal Article

Amyotroph Lateral Scler Frontotemporal Degener, 23 (7-8), 2022.

Abstract | Links:

Liao C, Castonguay CE, Heilbron K, Vuokila V, Medeiros M, Houle G, Akçimen F, Ross JP, Catoire H, Diez-Fairen M, Kang J, Mueller SH, Girard SL, Hopfner F, Lorenz D, Clark LN, Soto-Beasley AI, Klebe S, Hallett M, Wszolek ZK, Pendziwiat M, Lorenzo-Betancor O, Seppi K, Berg D, Vilariño-Güell C, Postuma RB, Bernard G, Dupré N, Jankovic J, Testa CM, Ross OA, Arzberger T, Chouinard S, Louis ED, Mandich P, Vitale C, Barone P, García-Martín E, Alonso-Navarro H, Agúndez JAG, Jiménez-Jiménez FJ, Pastor P, Rajput A, Deuschl G, Kuhlenbaümer G, Meijer IA, Dion PA, Rouleau GA,

Association of Essential Tremor With Novel Risk Loci: A Genome-Wide Association Study and Meta-analysis

Journal Article

JAMA Neurol, 79 (2), 2022.

Abstract | Links:

Roy V, Ross JP, Pépin R, Cortez Ghio S, Brodeur A, Touzel Deschênes L, Le-Bel G, Phillips DE, Milot G, Dion PA, Guérin S, Germain L, Berthod F, Auger FA, Rouleau GA, Dupré N, Gros-Louis F

Moyamoya Disease Susceptibility Gene RNF213 Regulates Endothelial Barrier Function

Journal Article

Stroke, 53 (4), 2022.

Abstract | Links:

Ishaque A, Ta D, Khan M, Zinman L, Korngut L, Genge A, Dionne A, Briemberg H, Luk C, Yang YH, Beaulieu C, Emery D, Eurich DT, Frayne R, Graham S, Wilman A, Dupré N, Kalra S

Distinct patterns of progressive gray and white matter degeneration in amyotrophic lateral sclerosis

Journal Article

Hum Brain Mapp, 43 (5), 2022.

Abstract | Links:

Salmon K, Anoja N, Breiner A, Chum M, Dionne A, Dupré N, Fiander A, Fok D, Ghavanini A, Gosselin S, Izenberg A, Johnston W, Kalra S, Matte G, Melanson M, O'Connell C, Ritsma B, Schellenberg K, Shoesmith C, Tremblay S, Williams H, Genge A

Genetic testing for amyotrophic lateral sclerosis in Canada - an assessment of current practices

Journal Article

Amyotroph Lateral Scler Frontotemporal Degener, 23 (3-4), 2022.

Abstract | Links:

Giguère-Rancourt A, Plourde M, Racine E, Couture M, Langlois M, Dupré N, Simard M

Altered Theory of Mind in Parkinson's Disease and Impact on Caregivers: A Pilot Study

Journal Article

Can J Neurol Sci, 49 (3), 2022.

Abstract | Links:

de Rus Jacquet A, Bogard S, Normandeau CP, Degroot C, Postuma RB, Dupré N, Miyasaki JM, Monchi O, Martino D, Fon EA, Cicchetti F

Clinical perception and management of Parkinson's disease during the COVID-19 pandemic: A Canadian experience

Journal Article

Parkinsonism Relat Disord, 91 , 2021.

Abstract | Links:

149 entries « ‹ 2 of 15 › »
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Active projects

  • Comprehensive Analysis Platform To Understand,Remedy and Eliminate ALS, from 2021-01-01 to 2025-03-31
  • Creating an Open Science Repository of ARCA1 iPSCs, from 2021-05-31 to 2023-05-31
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models, from 2023-03-01 to 2024-02-29
  • Développement d’une approche en santé durable pour la recherche sur le Parkinson et les troubles associés, from 2022-04-29 to 2023-04-30
  • Reseau Parkinson Québec_RPQ / Quebec Parkinson, from 2022-04-01 to 2023-03-31
  • The Canadian Parkinson Network, from 2018-10-01 to 2023-09-30

Recently finished projects

  • Capture ALS - Time Frame, from 2021-10-28 to 2022-10-27
  • Creating an Open Science Repository of ARSACS hiPSCs, from 2020-10-23 to 2021-10-22
  • Crosstalk between immune response and metabolic signaling: targeting leptin/AMPK axis to restore metabolic homeostasis in ALS, from 2021-02-01 to 2023-01-31
  • Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, from 2017-04-01 to 2022-03-31
  • Projet 2016-2792 pour les activités de recrutement, from 2019-04-04 to 2021-03-31
Data provided by the Université Laval research projects registery