Dr. Dupré is a neurologist at the CHU de Québec-Laval University, a Full Professor in the Department of Medicine of the School of Medicine (Laval University), and the Director of the Neuromuscular and Neurogenetic Disease Clinic of the CHU de Québec – Université Laval.

Dr. Dupré completed his medical training at McGill University and his residency in neurology at Laval University. He completed his postdoctoral training at the Montreal Neurological Hospital and Institute and at Harvard University. In 2007, he discovered a gene (syne-1) implicated in a new form of hereditary ataxia that has since been highly recognized internationally. Dr. Dupré also played an important role in the discovery of the involvement of the TARDBP in the etiology of amyotrophic lateral sclerosis. He is now involved in several provincial, national, and international networks that contribute to the discovery of genes involved in neurological diseases. He has generated more than 100 original publications. Dr. Dupré’s remarkable achievements have earned him several awards, including the 2015 Quebec Society of Muscular Dystrophy Award – ALS component – related to his involvement in the Clinic for Neuromuscular and Neurogenetic Diseases.

The research component of the clinic has grown significantly in recent years, with the creation of the Québec Parkinson Network (rpq-qpn.ca). The network connects clinicians with basic science researchers in the field, giving access to a registry of nearly 1000 patients. In addition to his clinical program, Dr. Dupré is involved in research projects linking clinical and basic research. This is done in collaboration with Dr. François Gros-Louis, of the LOEX research center at CHU de Québec – Laval University. One of these projects aims to discover biomarkers of amyotrophic lateral sclerosis in the skin. Another important project Dr. Dupré takes part in focuses on the development of a reconstructed skin model to study neurofibromatosis. Finally, Dr. Dupré is actively collaborating with Dr. Gros-Louis to identify pathogenic mechanisms of intracranial aneurysms in the Inuit and French-Canadian populations and to develop in vitro models of the disease. This project has just been funded by CIHR for a duration of 5 years.

1401, 18e Rue
Département des sciences neurologiques
Québec, Québec
Canada G1J 1Z4
+1 418-649-0252, extension 63177
+1 418-649-5915
nicolas.dupre@chudequebec... nicolas.dupre@crchudequeb...

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Salem IH, Beaudin M, Klein CJ, Dupré N

Treatment and Management of Autosomal Recessive Cerebellar Ataxias: Current Advances and Future Perspectives

Journal Article

CNS Neurol Disord Drug Targets, 22 (5), 2023.

Abstract | Links:

Picher-Martel V, Magnussen C, Blais M, Bubela T, Das S, Dionne A, Evans AC, Genge A, Greiner R, Iturria-Medina Y, Johnston W, Jones K, Kaneb H, Karamchandani J, Moradipoor S, Robertson J, Rogaeva E, Taylor DM, Vande Velde C, Yunusova Y, Zinman L, Kalra S, Dupré N

CAPTURE ALS: the comprehensive analysis platform to understand, remedy and eliminate ALS

Journal Article

Amyotroph Lateral Scler Frontotemporal Degener, 24 (1-2), 2023.

Abstract | Links:

Roy V, Brodeur A, Touzel Deschênes L, Dupré N, Gros-Louis F

RNF213 Loss-of-Function Promotes Angiogenesis of Cerebral Microvascular Endothelial Cells in a Cellular State Dependent Manner

Journal Article

Cells, 12 (1), 2022.

Abstract | Links:

Shaikh AG, Kim JS, Froment C, Koo YJ, Dupre N, Hadjivassiliou M, Honnorat J, Kothari S, Mitoma H, Rodrigue X, Soong BW, Subramony SH, Strupp M, Schmahmann J, Manto M

Scale for Ocular motor Disorders in Ataxia (SODA)

Journal Article

J Neurol Sci, 443 , 2022.

Abstract | Links:

Senkevich K, Zorca CE, Dworkind A, Rudakou U, Somerville E, Yu E, Ermolaev A, Nikanorova D, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Greenbaum L, Hassin-Baer S, Grenn FP, Chiang MSR, Sardi SP, Vanderperre B, Blauwendraat C, Trempe JF, Fon EA, Durcan TM, Alcalay RN, Gan-Or Z

GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease

Journal Article

Brain, 2022.

Abstract | Links:

Ross JP, Akçimen F, Liao C, Spiegelman D, Weisburd B, Dupré N, Dion PA, Rouleau GA, Farhan SMK

Questioning the Association of the STMN2 Dinucleotide Repeat With Amyotrophic Lateral Sclerosis

Journal Article

Neurol Genet, 8 (4), 2022.

Abstract | Links:

Jardim LB, Hasan A, Kuo SH, Magaña JJ, França M, Marques W, Camejo C, Santana-da-Silva LC, Leão EE, Espíndola G, Canals F, Miranda M, Salvatierra I, Cornejo-Olivas M, Fernandez-Ruiz J, Braga-Neto P, Dávila-Ortiz de Montellano DJ, Flores-Lagunes LL, Dupré N, Brais B, Vargas FR, Godeiro C, Coutinho L, Teive HG, Kaufmann M, Saffie P, Furtado GV, Saraiva-Pereira ML, Barsottini O, Pedroso JL, Rodríguez-Labrada R, Velázquez-Pérez L, Gomez C,

An Exploratory Survey on the Care for Ataxic Patients in the American Continents and the Caribbean

Journal Article

Cerebellum, 2022.

Abstract | Links:

Bharti K, J Graham S, Benatar M, Briemberg H, Chenji S, Dupré N, Dionne A, Frayne R, Genge A, Korngut L, Luk C, Zinman L, Kalra S,

Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States

Journal Article

PLoS One, 17 (6), 2022.

Abstract | Links:

Bensaidane MR, Picher-Martel V, Émond F, De Serres G, Dupré N, Beauchemin P

Case Report: Acute Necrotizing Encephalopathy Following COVID-19 Vaccine

Journal Article

Front Neurol, 13 , 2022.

Abstract | Links:

Bussiere N, Mei J, Levesque-Boissonneault C, Blais M, Carazo S, Gros-Louis F, Laforce R, De Serres G, Dupre N, Frasnelli J

Persisting chemosensory impairments in 366 healthcare workers following COVID-19: an 11-month follow-up

Journal Article

Chem Senses, 47 , 2022.

Abstract | Links:

149 entries « ‹ 1 of 15 › »
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Active projects

  • Comprehensive Analysis Platform To Understand,Remedy and Eliminate ALS, from 2021-01-01 to 2025-03-31
  • Creating an Open Science Repository of ARCA1 iPSCs, from 2021-05-31 to 2023-05-31
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models, from 2023-03-01 to 2024-02-29
  • Développement d’une approche en santé durable pour la recherche sur le Parkinson et les troubles associés, from 2022-04-29 to 2023-04-30
  • Reseau Parkinson Québec_RPQ / Quebec Parkinson, from 2022-04-01 to 2023-03-31
  • The Canadian Parkinson Network, from 2018-10-01 to 2023-09-30

Recently finished projects

  • Capture ALS - Time Frame, from 2021-10-28 to 2022-10-27
  • Creating an Open Science Repository of ARSACS hiPSCs, from 2020-10-23 to 2021-10-22
  • Crosstalk between immune response and metabolic signaling: targeting leptin/AMPK axis to restore metabolic homeostasis in ALS, from 2021-02-01 to 2023-01-31
  • Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, from 2017-04-01 to 2022-03-31
  • Projet 2016-2792 pour les activités de recrutement, from 2019-04-04 to 2021-03-31
Data provided by the Université Laval research projects registery