Dr. Dupré is a neurologist at the CHU de Québec-Laval University, a Full Professor in the Department of Medicine of the School of Medicine (Laval University), and the Director of the Neuromuscular and Neurogenetic Disease Clinic of the CHU de Québec – Université Laval.
Dr. Dupré completed his medical training at McGill University and his residency in neurology at Laval University. He completed his postdoctoral training at the Montreal Neurological Hospital and Institute and at Harvard University. In 2007, he discovered a gene (syne-1) implicated in a new form of hereditary ataxia that has since been highly recognized internationally. Dr. Dupré also played an important role in the discovery of the involvement of the TARDBP in the etiology of amyotrophic lateral sclerosis. He is now involved in several provincial, national, and international networks that contribute to the discovery of genes involved in neurological diseases. He has generated more than 100 original publications. Dr. Dupré’s remarkable achievements have earned him several awards, including the 2015 Quebec Society of Muscular Dystrophy Award – ALS component – related to his involvement in the Clinic for Neuromuscular and Neurogenetic Diseases.
The research component of the clinic has grown significantly in recent years, with the creation of the Québec Parkinson Network (rpq-qpn.ca). The network connects clinicians with basic science researchers in the field, giving access to a registry of nearly 1000 patients. In addition to his clinical program, Dr. Dupré is involved in research projects linking clinical and basic research. This is done in collaboration with Dr. François Gros-Louis, of the LOEX research center at CHU de Québec – Laval University. One of these projects aims to discover biomarkers of amyotrophic lateral sclerosis in the skin. Another important project Dr. Dupré takes part in focuses on the development of a reconstructed skin model to study neurofibromatosis. Finally, Dr. Dupré is actively collaborating with Dr. Gros-Louis to identify pathogenic mechanisms of intracranial aneurysms in the Inuit and French-Canadian populations and to develop in vitro models of the disease. This project has just been funded by CIHR for a duration of 5 years.
Département des sciences neurologiques
Canada G1J 1Z4
- [ULaval Nouvelles] COVID-19: des effets persistants sur le goût et l’odorat chez le tiers des personnes infectées 2022-05-30
- [Le Soleil] Premières lignes directrices canadiennes pour la prise en charge de la SLA 2020-11-18
- [Radio-Canada] COVID-19 et perte d’odorat sous la loupe des chercheurs du CHU de Québec 2020-09-01
- Blais, MathieuEmployeeHôpital de l'Enfant-Jésus+1 418-990-8255, extension firstname.lastname@example.orgMATHIEU.BLAIS@crchudequebec.ulaval.ca
1401 18e Rue
LOEX / CMDGT
Ville de Québec, QC
Canada G1J 1Z4
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Treatment and Management of Autosomal Recessive Cerebellar Ataxias: Current Advances and Future PerspectivesJournal Article
CNS Neurol Disord Drug Targets, 22 (5), 2023.
CAPTURE ALS: the comprehensive analysis platform to understand, remedy and eliminate ALSJournal Article
Amyotroph Lateral Scler Frontotemporal Degener, 24 (1-2), 2023.
RNF213 Loss-of-Function Promotes Angiogenesis of Cerebral Microvascular Endothelial Cells in a Cellular State Dependent MannerJournal Article
Cells, 12 (1), 2022.
Scale for Ocular motor Disorders in Ataxia (SODA)Journal Article
J Neurol Sci, 443 , 2022.
GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's diseaseJournal Article
Questioning the Association of the STMN2 Dinucleotide Repeat With Amyotrophic Lateral SclerosisJournal Article
Neurol Genet, 8 (4), 2022.
An Exploratory Survey on the Care for Ataxic Patients in the American Continents and the CaribbeanJournal Article
Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United StatesJournal Article
PLoS One, 17 (6), 2022.
Case Report: Acute Necrotizing Encephalopathy Following COVID-19 VaccineJournal Article
Front Neurol, 13 , 2022.
Persisting chemosensory impairments in 366 healthcare workers following COVID-19: an 11-month follow-upJournal Article
Chem Senses, 47 , 2022.
- Comprehensive Analysis Platform To Understand,Remedy and Eliminate ALS, from 2021-01-01 to 2025-03-31
- Creating an Open Science Repository of ARCA1 iPSCs, from 2021-05-31 to 2023-05-31
- Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models, from 2023-03-01 to 2024-02-29
- Développement d’une approche en santé durable pour la recherche sur le Parkinson et les troubles associés, from 2022-04-29 to 2023-04-30
- Recherche clinique en vue de mettre en ligne le test de sévérité des commotions cérébrales et création d'un registre de participants , from 2022-11-01 to 2023-03-31
- Reseau Parkinson Québec_RPQ / Quebec Parkinson, from 2022-04-01 to 2023-03-31
- The Canadian Parkinson Network, from 2018-10-01 to 2023-09-30
Recently finished projects
- Capture ALS - Time Frame, from 2021-10-28 to 2022-10-27
- Creating an Open Science Repository of ARSACS hiPSCs, from 2020-10-23 to 2021-10-22
- Crosstalk between immune response and metabolic signaling: targeting leptin/AMPK axis to restore metabolic homeostasis in ALS, from 2021-02-01 to 2023-01-31
- Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, from 2017-04-01 to 2022-03-31
- Projet 2016-2792 pour les activités de recrutement, from 2019-04-04 to 2021-03-31