Dr. Michel Lebel PhD is a full professor in the Department of Molecular Biology, Medical Biochemistry, and Pathology at Laval University. Dr. Lebel obtained his PhD from Université de Montréal and completed post-doctoral studies in the Department of Genetics at Harvard Medical School. He has been an independent investigator since 2000 at the Centre de Recherche du CHU de Québec. His research focuses on deciphering the molecular and cellular events leading to premature aging in a mouse model of Werner syndrome. Press releases on the results of his work have been published by the Science Daily news, the National Post, Medical News Today, the Montreal Gazette, and the Nutraceuticals World online magazine. He was interviewed by the CBC radio (107,7 FM) on January 11th, 2010 and by the Journal de Québec on September 30th, 2012 (Le vieillissement, plus qu’une affaire de gènes).

Since the middle of the last century, improvements in healthcare have increased human life expectancy. However, we are now facing the new challenge and paradox of an older population with increased longevity, but often still with many years of poor health or disability ahead of them. A better understanding of the mechanisms leading to the decline in function with age would provide new predictive biomarkers and potential therapeutic targets. It is now clear that each person’s genetic code has a significant influence on the aging process. The main goal of Dr. Lebel’s research is to understand why a slight modification of certain genes precipitates the onset of age-related diseases, and to identify key biological factors leading to the onset of these diseases. In addition, using cutting-edge technologies, his team is working to understand how vitamin C and other natural products may prevent age-related diseases in humans. To do this, Dr. Lebel is studying a mouse model of a human genetic disorder called Werner syndrome, characterized by premature aging in affected patients. Finally, Dr. Lebel’s laboratory is also working to identify key proteins in the blood that would help diagnose cancer more quickly in patients.

CHUL
2705, boulevard Laurier
R-2714
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46234
Michel.Lebel@crchudequebe...

Latest news

49 entries « ‹ 5 of 5 › »

Turaga RV, Massip L, Chavez A, Johnson FB, Lebel M

Werner syndrome protein prevents DNA breaks upon chromatin structure alteration

Journal Article

Aging Cell, 6 (4), 2007.

Abstract | Links:

Guay D, Gaudreault I, Massip L, Lebel M

Formation of a nuclear complex containing the p53 tumor suppressor, YB-1, and the Werner syndrome gene product in cells treated with UV light

Journal Article

Int J Biochem Cell Biol, 38 (8), 2006.

Abstract | Links:

Massip L, Garand C, Turaga RV, Deschenes F, Thorin E, Lebel M

Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue

Journal Article

Exp Gerontol, 41 (2), 2006.

Abstract | Links:

Laud PR, Multani AS, Bailey SM, Wu L, Ma J, Kingsley C, Lebel M, Pathak S, DePinho RA, Chang S

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

Journal Article

Genes Dev, 19 (21), 2005.

Abstract | Links:

Lavoie J, Carter R, Drouin R, Lebel M

Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1

Journal Article

Cancer Genet Cytogenet, 156 (2), 2005.

Abstract | Links:

Deschenes F, Massip L, Garand C, Lebel M

In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1

Journal Article

Hum Mol Genet, 14 (21), 2005.

Abstract | Links:

Gaudreault I, Guay D, Lebel M

YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins

Journal Article

Nucleic Acids Res, 32 (1), 2004.

Abstract | Links:

Lavoie J, Bronsard M, Lebel M, Drouin R

Mouse telomere analysis using an optimized primed in situ (PRINS) labeling technique

Journal Article

Chromosoma, 111 (7), 2003.

Abstract | Links:

Lebel M, Lavoie J, Gaudreault I, Bronsard M, Drouin R

Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice

Journal Article

Am J Pathol, 162 (5), 2003.

Abstract | Links:

49 entries « ‹ 5 of 5 › »
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Active projects

  • Oxidative stress in the endoplasmic reticulum and its impact on liver inflammation in an aging mouse model, from 2020-10-01 to 2025-09-30

Recently finished projects

  • Cibler l’instabilité génomique en tant que vulnérabilité essentielle du cancer de l’ovaire, from 2018-10-01 to 2021-09-30
  • Validation of a serum signature proteome profile for serum vitamin C levels in human subjects at risk of developing type 2 diabetes, from 2021-09-08 to 2022-03-31
Data provided by the Université Laval research projects registery