Dr. Michel Lebel PhD is a full professor in the Department of Molecular Biology, Medical Biochemistry, and Pathology at Laval University. Dr. Lebel obtained his PhD from Université de Montréal and completed post-doctoral studies in the Department of Genetics at Harvard Medical School. He has been an independent investigator since 2000 at the Centre de Recherche du CHU de Québec. His research focuses on deciphering the molecular and cellular events leading to premature aging in a mouse model of Werner syndrome. Press releases on the results of his work have been published by the Science Daily news, the National Post, Medical News Today, the Montreal Gazette, and the Nutraceuticals World online magazine. He was interviewed by the CBC radio (107,7 FM) on January 11th, 2010 and by the Journal de Québec on September 30th, 2012 (Le vieillissement, plus qu’une affaire de gènes).

Since the middle of the last century, improvements in healthcare have increased human life expectancy. However, we are now facing the new challenge and paradox of an older population with increased longevity, but often still with many years of poor health or disability ahead of them. A better understanding of the mechanisms leading to the decline in function with age would provide new predictive biomarkers and potential therapeutic targets. It is now clear that each person’s genetic code has a significant influence on the aging process. The main goal of Dr. Lebel’s research is to understand why a slight modification of certain genes precipitates the onset of age-related diseases, and to identify key biological factors leading to the onset of these diseases. In addition, using cutting-edge technologies, his team is working to understand how vitamin C and other natural products may prevent age-related diseases in humans. To do this, Dr. Lebel is studying a mouse model of a human genetic disorder called Werner syndrome, characterized by premature aging in affected patients. Finally, Dr. Lebel’s laboratory is also working to identify key proteins in the blood that would help diagnose cancer more quickly in patients.

CHUL
2705, boulevard Laurier
R-2714
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46234
Michel.Lebel@crchudequebe...

Latest news

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Aumailley L, Warren A, Garand C, Dubois MJ, Paquet ER, Le Couteur DG, Marette A, Cogger VC, Lebel M

Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice

Journal Article

Aging (Albany NY), 8 (3), 2016.

Abstract | Links:

Paquet ER, Cui J, Davidson D, Pietrosemoli N, Hassan HH, Tsofack SP, Maltais A, Hallett MT, Delorenzi M, Batist G, Aloyz R, Lebel M

A 12-gene signature to distinguish colon cancer patients with better clinical outcome following treatment with 5-fluorouracil or FOLFIRI

Journal Article

J Pathol Clin Res, 1 (3), 2015.

Abstract | Links:

Paquet ER, Hovington H, Brisson H, Lacombe C, Larue H, Tetu B, Lacombe L, Fradet Y, Lebel M

Low level of the X-linked ribosomal protein S4 in human urothelial carcinomas is associated with a poor prognosis

Journal Article

Biomark Med, 9 (3), 2015.

Abstract | Links:

Aumailley L, Garand C, Dubois MJ, Johnson FB, Marette A, Lebel M

Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice

Journal Article

PLoS One, 10 (10), 2015.

Abstract | Links:

Aumailley L, Dubois MJ, Garand C, Marette A, Lebel M

Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase

Journal Article

Exp Gerontol, 72 , 2015.

Abstract | Links:

Dallaire A, Proulx S, Simard MJ, Lebel M

Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span

Journal Article

BMC Genomics, 15 , 2014.

Abstract | Links:

Cogger VC, Svistounov D, Warren A, Zykova S, Melvin RG, Solon-Biet SM, O'Reilly JN, McMahon AC, Ballard JW, De Cabo R, Le Couteur DG, Lebel M

Liver aging and pseudocapillarization in a Werner syndrome mouse model

Journal Article

J Gerontol A Biol Sci Med Sci, 69 (9), 2014.

Abstract | Links:

Girard MJ, Lebel M, Picard F

Long non-coding RNAs: key regulators of age-related diseases?

Journal Article

2 (3), 2013.

Tsofack SP, Meunier L, Sanchez L, Madore J, Provencher D, Mes-Masson AM, Lebel M

Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis

Journal Article

BMC Cancer, 13 , 2013.

Abstract | Links:

Krietsch J, Rouleau M, Lebel M, Poirier G, Masson JY

Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair

Book Chapter

Panasci L, Aloyz R, Alaoui-Jamali M (Ed.): Advances in DNA Repair in Cancer Therapy, pp. 167-186, New York, NY, Springer, 2012, ISBN: 9781461447412.

49 entries « ‹ 2 of 5 › »
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Active projects

  • Oxidative stress in the endoplasmic reticulum and its impact on liver inflammation in an aging mouse model, from 2020-10-01 to 2025-09-30

Recently finished projects

  • Cibler l’instabilité génomique en tant que vulnérabilité essentielle du cancer de l’ovaire, from 2018-10-01 to 2021-09-30
  • Validation of a serum signature proteome profile for serum vitamin C levels in human subjects at risk of developing type 2 diabetes, from 2021-09-08 to 2022-03-31
Data provided by the Université Laval research projects registery