Dr. Michel J. Tremblay is a regular researcher in the field of infectious and immune diseases at the CHU Research Center of Québec-Laval University. He is also a Professor in the Department of Microbiology-Infectiology and Immunology of the School of Medicine at Laval University, and holds the Canada Research Chair in Human Immuno-Retrovirology.

He has been Vice-Dean, Research and Graduate Studies at the Faculty of Medicine, and is currently Assistant Vice-President, Research, Creation and Innovation at Laval University. Dr. Tremblay has published over 200 articles in peer-reviewed scientific journals, and to date has received nearly $ 15 million in funding as a principal investigator and just under $ 40 million in funding as co-researcher for his research projects. Dr. Tremblay has received several awards and distinctions, including the André Dupont Award from the Clinical Research Club of Quebec and the Léo-Pariseau Award from ACFAS. Dr. Tremblay is a member of the Canadian Research Consortium on HIV Healing (CanCURE) which is funded by the Canadian Institutes of Health Research (CIHR).

His research aims to deepen our knowledge of the pathogenesis of human immunodeficiency virus (HIV) infection, the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). His research focuses on several facets of HIV infection, such as the complex interactions that occur between HIV and certain target cells of the virus (e.g., macrophages, CD4 T cells, astrocytes, etc.) and large-scale analysis of gene expression patterns following viral infection, using DNA microarrays and RNA sequencing in combination with powerful bioinformatic tools.

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Dusserre N, Lessard C, Paquette N, Perron S, Poulin L, Tremblay M, Beauchamp D, Désormeaux A, Bergeron MG

Encapsulation of foscarnet in liposomes modifies drug intracellular accumulation, in vitro anti-HIV-1 activity, tissue distribution and pharmacokinetics

Journal Article

AIDS, 9 (8), 1995.

Abstract | Links:

Harvie P, Désormeaux A, Gagné N, Tremblay M, Poulin L, Beauchamp D, Bergeron MG

Lymphoid tissues targeting of liposome-encapsulated 2',3'-dideoxyinosine

Journal Article

AIDS, 9 (7), 1995.

Abstract | Links:

Omar RF, Dusserre N, Désormeaux A, Poulin L, Tremblay M, Beauchamp D, Bergeron MG

Liposomal encapsulation of foscarnet protects against hypocalcemia induced by free foscarnet

Journal Article

Antimicrob Agents Chemother, 39 (9), 1995.

Abstract | Links:

Tremblay M, Meloche S, Gratton S, Wainberg MA, Sékaly RP

Association of p56lck with the cytoplasmic domain of CD4 modulates HIV-1 expression

Journal Article

EMBO J, 13 (4), 1994.

Abstract | Links:

Désormeaux A, Harvie P, Perron S, Makabi-Panzu B, Beauchamp D, Tremblay M, Poulin L, Bergeron MG

Antiviral efficacy, intracellular uptake and pharmacokinetics of free and liposome-encapsulated 2',3'-dideoxyinosine

Journal Article

AIDS, 8 (11), 1994.

Abstract | Links:

Makabi-Panzu B, Lessard C, Perron S, Désormeaux A, Tremblay M, Poulin L, Beauchamp D, Bergeron MG

Comparison of cellular accumulation, tissue distribution, and anti-HIV activity of free and liposomal 2',3'-dideoxycytidine

Journal Article

AIDS Res Hum Retroviruses, 10 (11), 1994.

Abstract | Links:

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Active projects

  • Canadian HIV Cure Enterprise 2.0: Targeting the interplay between myeloid cells and C04+ T-cells for HIV cure, from 2019-04-01 to 2024-03-31
  • Contribution - consortium Érudit, from 2022-01-01 to 2024-04-30
  • Manufacturing of antigens and adjuvants for development of vaccines (MAAV), from 2021-07-01 to 2023-03-31
  • Microglia as a viral reservoir for HIV-1 in the human brain and its role in neuroinflammation, from 2021-04-01 to 2026-03-31

Recently finished projects

  • Centre de recherche sur les interactions hôte-parasite (CRIHP), from 2015-04-01 to 2021-03-31
  • Chaire du recherche du Canada en immuno-rétrovirologie humaine, from 2015-01-01 to 2021-12-31
Data provided by the Université Laval research projects registery