Dr. Michel J. Tremblay is a regular researcher in the field of infectious and immune diseases at the CHU Research Center of Québec-Laval University. He is also a Professor in the Department of Microbiology-Infectiology and Immunology of the School of Medicine at Laval University, and holds the Canada Research Chair in Human Immuno-Retrovirology.

He has been Vice-Dean, Research and Graduate Studies at the Faculty of Medicine, and is currently Assistant Vice-President, Research, Creation and Innovation at Laval University. Dr. Tremblay has published over 200 articles in peer-reviewed scientific journals, and to date has received nearly $ 15 million in funding as a principal investigator and just under $ 40 million in funding as co-researcher for his research projects. Dr. Tremblay has received several awards and distinctions, including the André Dupont Award from the Clinical Research Club of Quebec and the Léo-Pariseau Award from ACFAS. Dr. Tremblay is a member of the Canadian Research Consortium on HIV Healing (CanCURE) which is funded by the Canadian Institutes of Health Research (CIHR).

His research aims to deepen our knowledge of the pathogenesis of human immunodeficiency virus (HIV) infection, the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). His research focuses on several facets of HIV infection, such as the complex interactions that occur between HIV and certain target cells of the virus (e.g., macrophages, CD4 T cells, astrocytes, etc.) and large-scale analysis of gene expression patterns following viral infection, using DNA microarrays and RNA sequencing in combination with powerful bioinformatic tools.

CHUL
2705, boulevard Laurier
R-2701.4
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 48274 / 48624+1 418-654-2715
michel.j.tremblay@crchude...

Latest news

210 entries « ‹ 1 of 21 › »

Langlois M, Bounou S, Tremblay MJ, Barbeau B

Infection of the Ex Vivo Tonsil Model by HTLV-1 Envelope-Pseudotyped Viruses

Journal Article

Pathogens, 12 (2), 2023.

Abstract | Links:

Hany L, Turmel MO, Barat C, Ouellet M, Tremblay MJ

Impact of latency-reversing agents on human macrophage physiology

Journal Article

Immun Inflamm Dis, 11 (1), 2023.

Abstract | Links:

Lodge R, Xu Z, Eklund M, Stürzel C, Kirchhoff F, Tremblay MJ, Hobman TC, Cohen ÉA

MicroRNA-25/93 induction by Vpu as a mechanism for counteracting MARCH1-restriction on HIV-1 infectivity in macrophages

Journal Article

mBio, 14 (5), 2023.

Abstract | Links:

Lepard M, Yang JX, Afkhami S, Nazli A, Zganiacz A, Tang S, Choi MWY, Vahedi F, Deshiere A, Tremblay MJ, Xing Z, Kaushic C, Gillgrass A

Comparing Current and Next-Generation Humanized Mouse Models for Advancing HIV and HIV/Mtb Co-Infection Studies

Journal Article

Viruses, 14 (9), 2022.

Abstract | Links:

Hany L, Turmel MO, Barat C, Ouellet M, Tremblay MJ

Bryostatin-1 Decreases HIV-1 Infection and Viral Production in Human Primary Macrophages

Journal Article

J Virol, 96 (4), 2022.

Abstract | Links:

Saba I, Barat C, Chabaud S, Reyjon N, Leclerc M, Jakubowska W, Orabi H, Lachhab A, Pelletier M, Tremblay MJ, Bolduc S

Immunocompetent Human 3D Organ-Specific Hormone-Responding Vaginal Mucosa Model of HIV-1 Infection

Journal Article

Tissue Eng Part C Methods, 27 (3), 2021.

Abstract | Links:

Desrosiers V, Barat C, Breton Y, Ouellet M, Tremblay MJ

Thymidylate synthase is essential for efficient HIV-1 replication in macrophages

Journal Article

Virology, 561 , 2021.

Abstract | Links:

Sénécal V, Barat C, Gagnon MT, Vanasse F, Leboeuf M, Gosselin D, Tremblay MJ

Altered expression of fractalkine in HIV-1-infected astrocytes and consequences for the virus-related neurotoxicity

Journal Article

J Neurovirol, 27 (2), 2021.

Abstract | Links:

Wessels JM, Nguyen PV, Vitali D, Mueller K, Vahedi F, Felker AM, Dupont HA, Bagri P, Verschoor CP, Deshiere A, Mazzulli T, Tremblay MJ, Ashkar AA, Kaushic C

Depot medroxyprogesterone acetate (DMPA) enhances susceptibility and increases the window of vulnerability to HIV-1 in humanized mice

Journal Article

Sci Rep, 11 (1), 2021.

Abstract | Links:

Caballero RE, Dong SXM, Gajanayaka N, Ali H, Cassol E, Cameron WD, Korneluk R, Tremblay MJ, Angel JB, Kumar A

Author Correction: Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages

Journal Article

Sci Rep, 11 (1), 2021.

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210 entries « ‹ 1 of 21 › »
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Active projects

  • Canadian HIV Cure Enterprise 2.0: Targeting the interplay between myeloid cells and C04+ T-cells for HIV cure, from 2019-04-01 to 2025-03-31
  • Microglia as a viral reservoir for HIV-1 in the human brain and its role in neuroinflammation, from 2021-04-01 to 2026-03-31

Recently finished projects

  • Contribution - consortium Érudit, from 2022-01-01 to 2024-04-30
  • Manufacturing of antigens and adjuvants for development of vaccines (MAAV), from 2021-07-01 to 2024-03-31
Data provided by the Université Laval research projects registery