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24 entries « 1 of 3 »

Gutierrez V, Kim-Vasquez D, Shum M, Yang Q, Dikeman D, Louie SG, Shirihai OS, Tsukamoto H, Liesa M

The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis

Journal Article

Redox Biol, 70 , 2024.

Abstract | Links:

Belmas T, Liesa M, Shum M

Quantifying mitochondrial redox and bilirubin content in intact primary hepatocytes of obese mice using fluorescent reporters

Journal Article

STAR Protoc, 4 (3), 2023.

Abstract | Links:

Gonthier K, Weidmann C, Berthiaume L, Jobin C, Lacouture A, Lafront C, Harvey M, Neveu B, Loehr J, Bergeron A, Fradet Y, Lacombe L, Riopel J, Latulippe É, Atallah C, Shum M, Lambert JP, Pouliot F, Pelletier M, Audet-Walsh É

Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer

Journal Article

Mol Oncol, 17 (10), 2023.

Abstract | Links:

Zeng J, Acin-Perez R, Assali EA, Martin A, Brownstein AJ, Petcherski A, Fernández-Del-Rio L, Xiao R, Lo CH, Shum M, Liesa M, Han X, Shirihai OS, Grinstaff MW

Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

Journal Article

Nat Commun, 14 (1), 2023.

Abstract | Links:

Shum M, Segawa M, Gharakhanian R, Viñuela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M

Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance

Journal Article

Mol Metab, 55 , 2022.

Abstract | Links:

Shum M, Zhou Z, Liesa M

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Journal Article

J Vis Exp, (177), 2021.

Abstract | Links:

Shum M, Ngo J, Shirihai OS, Liesa M

Mitochondrial oxidative function in NAFLD: Friend or foe?

Journal Article

Mol Metab, 50 , 2021.

Abstract | Links:

Ngo J, Benador IY, Brownstein AJ, Vergnes L, Veliova M, Shum M, Acín-Pérez R, Reue K, Shirihai OS, Liesa M

Isolation and functional analysis of peridroplet mitochondria from murine brown adipose tissue

Journal Article

STAR Protoc, 2 (1), 2021.

Abstract | Links:

Shum M, Shintre CA, Althoff T, Gutierrez V, Segawa M, Saxberg AD, Martinez M, Adamson R, Young MR, Faust B, Gharakhanian R, Su S, Chella Krishnan K, Mahdaviani K, Veliova M, Wolf DM, Ngo J, Nocito L, Stiles L, Abramson J, Lusis AJ, Hevener AL, Zoghbi ME, Carpenter EP, Liesa M

ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity

Journal Article

Sci Transl Med, 13 (594), 2021.

Abstract | Links:

Chella Krishnan K, Vergnes L, Acín-Pérez R, Stiles L, Shum M, Ma L, Mouisel E, Pan C, Moore TM, Péterfy M, Romanoski CE, Reue K, Björkegren JLM, Laakso M, Liesa M, Lusis AJ

Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2

Journal Article

Nat Metab, 3 (11), 2021.

Abstract | Links:

24 entries « 1 of 3 »
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Active projects

  • Diabetes and Healthy Liver- Unravelling the links between postprandial metabolism in type 2 diabetes and progression of metabolic fatty liver disease, from 2022-04-01 to 2027-03-31
  • Fonds de démarrage pour chercheurs en debut de carrière – Bourse de recrutement étudiant, from 2023-07-01 to 2028-06-30
  • L'hétérogénéité mitochondriale et sa reprogrammation dans les maladies métaboliques - Subvention établissement de jeune chercheur, from 2023-04-01 to 2027-03-31
  • L'hétérogénéité mitochondriale et sa reprogrammation dans les maladies métaboliques., from 2023-07-01 to 2027-12-31
  • Mitochondria bound to lipid droplets as new regulators of insulin resistance, from 2022-12-01 to 2025-11-30
  • Rôle de la bilirubine endogène dans l’inflammation et la résistance à l’insuline, from 2023-04-01 to 2024-03-31
  • The mTORC1/2 and DEPTOR pathway regulates a novel prolipogenic mitochondrial population in obese mice, from 2022-04-01 to 2024-03-31
  • Understanding mitochondria and lipids droplet interactions in cell biology, from 2021-04-01 to 2026-03-31

Recently finished projects

  • ABCB10 reprograms mitochondria in pro-inflammatory macrophages of obese mice, from 2022-09-21 to 2023-03-31
  • Caractérisation du protéome mitochondrial de la prostate, from 2022-09-21 to 2023-03-31
  • Fonds de démarrage, Michael Shum, from 2021-01-11 to 2024-01-10
  • Understanding mitochondria and lipids droplet interactions in cell biology, from 2021-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery