Dr. Martin Simard, Ph.D., holds a Research Chair of the Fonds de Recherche-Santé du Québec and is professor in the Department of molecular biology, medical biochemistry, and pathology of the Laval University School of Medicine.

His research group aims to better understand how small non-coding RNAs can so efficiently control gene expression, in animals. Those molecules able to precisely control the protein production (the genes) in cells, have promptly being proposed to be implicated in different pathologies such as different types of cancers and recent scientific studies have proven their roles. The contribution of theses tiny molecules to our understanding of the cell, as well as their great potential in the detection and treatment of different diseases, makes this field of research among the most active in medical biology. His work focuses on the identification of cellular molecules that participate in the biological role of small non-coding RNAs, on understanding their roles and defining their implication in the development of different pathologies, such as cancers. At term, our studies will contribute to gather new insights about how theses tiny molecules contribute to cell function, and to develop new therapeutic strategies using the small non-coding RNAs.

L'Hôtel-Dieu de Québec
9, rue McMahon
0744-5
Québec, Québec
Canada G1R 2J6
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Zhong L, Simoneau B, Tremblay PL, Gout S, Simard MJ, Huot J

E-selectin-mediated adhesion and extravasation in cancer

Book Chapter

Schwab M (Ed.): Encyclopedia of Cancer, 4th edition, 2 , pp. 1618-1624, Springer-Verlag Berlin Heidelberg, 2017, ISBN: 9783662468746.

Roy-Bellavance C, Grants JM, Miard S, Lee K, Rondeau É, Guillemette C, Simard MJ, Taubert S, Picard F

The R148.3 Gene Modulates Caenorhabditis elegans Lifespan and Fat Metabolism

Journal Article

G3 (Bethesda), 7 (8), 2017.

Abstract | Links:

Zhong L, Simoneau B, Huot J, Simard MJ

p38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription

Journal Article

Oncotarget, 8 (1), 2017.

Abstract | Links:

Wang C, Gupta P, Fressigne L, Bosse GD, Wang X, Simard MJ, Hansen D

TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells

Journal Article

Nucleic Acids Res, 45 (3), 2017.

Abstract | Links:

Quevillon Huberdeau M, Zeitler DM, Hauptmann J, Bruckmann A, Fressigne L, Danner J, Piquet S, Strieder N, Engelmann JC, Jannot G, Deutzmann R, Simard MJ, Meister G

Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA-guided gene silencing

Journal Article

EMBO J, 36 (14), 2017.

Abstract | Links:

Jannot G, Michaud P, Quevillon Huberdeau M, Morel-Berryman L, Brackbill JA, Piquet S, McJunkin K, Nakanishi K, Simard MJ

GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis

Journal Article

PLoS Genet, 12 (12), 2016.

Abstract | Links:

Flamand MN, Wu E, Vashisht A, Jannot G, Keiper BD, Simard MJ, Wohlschlegel J, Duchaine TF

Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans

Journal Article

Nucleic Acids Res, 44 (12), 2016.

Abstract | Links:

Dallaire A, Simard MJ

The implication of microRNAs and endo-siRNAs in animal germline and early development

Journal Article

Dev Biol, 416 (1), 2016.

Abstract | Links:

Meziane O, Piquet S, Bosse GD, Gagne D, Paquet E, Robert C, Tones MA, Simard MJ

The human decapping scavenger enzyme DcpS modulates microRNA turnover

Journal Article

Sci Rep, 5 , 2015.

Abstract | Links:

Haj-Salem I, Fakhfakh R, Berube JC, Jacques E, Plante S, Simard MJ, Bosse Y, Chakir J

MicroRNA-19a enhances proliferation of bronchial epithelial cells by targeting TGFβR2 gene in severe asthma

Journal Article

Allergy, 70 (2), 2015.

Abstract | Links:

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Active projects

  • Canadian Developmental Biology Conference 2023, from 2021-04-01 to 2023-03-31
  • Genetic and molecular analysis of the siRNA-mediated gene regulation, from 2019-04-01 to 2024-03-31
  • Understanding the regulation and implication of Argonaute in microRNA-mediated gene silencing., from 2020-10-01 to 2025-09-30

Recently finished projects

  • Acquisition d'un appareil PCR pour analyses d'échantillons biologiques , from 2021-07-16 to 2022-07-15
  • Étude de la régulation des gènes par les courts ARNs non-codants, from 2017-07-01 to 2021-06-30
  • Functional dissection of the microRNA pathway., from 2015-07-01 to 2021-03-31
Data provided by the Université Laval research projects registery