Dr. Martin Simard, Ph.D., holds a Research Chair of the Fonds de Recherche-Santé du Québec and is professor in the Department of molecular biology, medical biochemistry, and pathology of the Laval University School of Medicine.

His research group aims to better understand how small non-coding RNAs can so efficiently control gene expression, in animals. Those molecules able to precisely control the protein production (the genes) in cells, have promptly being proposed to be implicated in different pathologies such as different types of cancers and recent scientific studies have proven their roles. The contribution of theses tiny molecules to our understanding of the cell, as well as their great potential in the detection and treatment of different diseases, makes this field of research among the most active in medical biology. His work focuses on the identification of cellular molecules that participate in the biological role of small non-coding RNAs, on understanding their roles and defining their implication in the development of different pathologies, such as cancers. At term, our studies will contribute to gather new insights about how theses tiny molecules contribute to cell function, and to develop new therapeutic strategies using the small non-coding RNAs.

L'Hôtel-Dieu de Québec
9, rue McMahon
0744-5
Québec, Québec
Canada G1R 2J6
55 entries « 1 of 6 »

Pal A, Vasudevan V, Houle F, Lantin M, Maniates KA, Huberdeau MQ, Abbott AL, Simard MJ

Defining the contribution of microRNA-specific Argonautes with slicer capability in animals

Journal Article

Nucleic Acids Res, 52 (9), 2024.

Abstract | Links:

Frédérick PM, Jannot G, Banville I, Simard MJ

Interaction between a J-domain co-chaperone and a specific Argonaute protein contributes to microRNA function in animals

Journal Article

Nucleic Acids Res, 52 (11), 2024.

Abstract | Links:

Shah VN, Neumeier J, Huberdeau MQ, Zeitler DM, Bruckmann A, Meister G, Simard MJ

Casein kinase 1 and 2 phosphorylate Argonaute proteins to regulate miRNA-mediated gene silencing

Journal Article

EMBO Rep, 24 (11), 2023.

Abstract | Links:

Kakumani PK, Ko Y, Ramakrishna S, Christopher G, Dodgson M, Shrinet J, Harvey LM, Shin C, Simard MJ

CSDE1 promotes miR-451 biogenesis

Journal Article

Nucleic Acids Res, 51 (17), 2023.

Abstract | Links:

Frédérick PM, Simard MJ

Regulation and different functions of the animal microRNA-induced silencing complex

Journal Article

Wiley Interdiscip Rev RNA, 13 (4), 2022.

Abstract | Links:

Quévillon Huberdeau M, Shah VN, Nahar S, Neumeier J, Houle F, Bruckmann A, Gypas F, Nakanishi K, Großhans H, Meister G, Simard MJ

A specific type of Argonaute phosphorylation regulates binding to microRNAs during C. elegans development

Journal Article

Cell Rep, 41 (11), 2022.

Abstract | Links:

Kakumani PK, Guitart T, Houle F, Harvey LM, Goyer B, Germain L, Gebauer F, Simard MJ

CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma

Journal Article

Oncogene, 40 (18), 2021.

Abstract | Links:

Michaud P, Shah VN, Adjibade P, Houle F, Quévillon Huberdeau M, Rioux R, Lavoie-Ouellet C, Gu W, Mazroui R, Simard MJ

The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans

Journal Article

PLoS Genet, 17 (4), 2021.

Abstract | Links:

Kakumani PK, Harvey LM, Houle F, Guitart T, Gebauer F, Simard MJ

CSDE1 controls gene expression through the miRNA-mediated decay machinery

Journal Article

Life Sci Alliance, 3 (4), 2020.

Abstract | Links:

Quevillon Huberdeau M, Simard MJ

A guide to microRNA-mediated gene silencing

Journal Article

FEBS J, 286 (4), 2019.

Abstract | Links:

55 entries « 1 of 6 »
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Active projects

  • Genetic and molecular analysis of the siRNA-mediated gene regulation, from 2019-04-01 to 2025-03-31
  • Understanding the regulation and implication of Argonaute in microRNA-mediated gene silencing., from 2020-10-01 to 2025-09-30

Recently finished projects

  • Acquisition d'un appareil PCR pour analyses d'échantillons biologiques , from 2021-07-16 to 2022-07-15
  • Canadian Developmental Biology Conference, from 2023-01-01 to 2023-12-31
  • Canadian Developmental Biology Conference 2023, from 2021-04-01 to 2023-03-31
  • Deciphering cellular modulators of the microRNA pathway, from 2023-03-01 to 2024-02-29
Data provided by the Université Laval research projects registery