Dr. Martin Simard, Ph.D., holds a Research Chair of the Fonds de Recherche-Santé du Québec and is professor in the Department of molecular biology, medical biochemistry, and pathology of the Laval University School of Medicine.
His research group aims to better understand how small non-coding RNAs can so efficiently control gene expression, in animals. Those molecules able to precisely control the protein production (the genes) in cells, have promptly being proposed to be implicated in different pathologies such as different types of cancers and recent scientific studies have proven their roles. The contribution of theses tiny molecules to our understanding of the cell, as well as their great potential in the detection and treatment of different diseases, makes this field of research among the most active in medical biology. His work focuses on the identification of cellular molecules that participate in the biological role of small non-coding RNAs, on understanding their roles and defining their implication in the development of different pathologies, such as cancers. At term, our studies will contribute to gather new insights about how theses tiny molecules contribute to cell function, and to develop new therapeutic strategies using the small non-coding RNAs.
9, rue McMahon
Canada G1R 2J6
- [Radio-Canada] Des petits vers très utiles dans la lutte contre le cancer 2021-07-13
- Plus de 4,6 millions de subventions des IRSC pour 8 projets de recherche du CRCHU 2020-09-29
- L’événement « Ensemble, nous pouvons le vaincre! » permet de recueillir 28 000$ pour la recherche contre le cancer 2019-10-18
Regulation and different functions of the animal microRNA-induced silencing complexJournal Article
Wiley Interdiscip Rev RNA, 2021.
The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegansJournal Article
PLoS Genet, 17 (4), 2021.
CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanomaJournal Article
Oncogene, 40 (18), 2021.
CSDE1 controls gene expression through the miRNA-mediated decay machineryJournal Article
Life Sci Alliance, 3 (4), 2020.
A guide to microRNA-mediated gene silencingJournal Article
FEBS J, 286 (4), 2019.
Defend Thyself and Thy OffspringJournal Article
Dev Cell, 50 (6), 2019.
p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cellsJournal Article
Sci Rep, 8 (1), 2018.
[Biogenesis of small non-coding RNAs in animals]Journal Article
Med Sci (Paris), 34 (2), 2018.
Somatic and Germline MicroRNAs Form Distinct Silencing Complexes to Regulate Their Target mRNAs DifferentlyJournal Article
Dev Cell, 47 (2), 2018.
Endothelial microRNAs regulating the NF-κB pathway and cell adhesion molecules during inflammationJournal Article
FASEB J, 32 (8), 2018.
- Acquisition d'un appareil PCR pour analyses d'échantillons biologiques , from 2021-07-16 to 2022-07-15
- Canadian Developmental Biology Conference 2023, from 2021-04-01 to 2023-03-31
- Genetic and molecular analysis of the siRNA-mediated gene regulation, from 2019-04-01 to 2024-03-31
- Understanding the regulation and implication of Argonaute in microRNA-mediated gene silencing., from 2020-10-01 to 2025-09-30
Recently finished projects
- Étude de la régulation des gènes par les courts ARNs non-codants, from 2017-07-01 to 2021-06-30
- Functional dissection of the microRNA pathway., from 2015-07-01 to 2021-03-31