Dr. Martin Simard, Ph.D., holds a Research Chair of the Fonds de Recherche-Santé du Québec and is professor in the Department of molecular biology, medical biochemistry, and pathology of the Laval University School of Medicine.

His research group aims to better understand how small non-coding RNAs can so efficiently control gene expression, in animals. Those molecules able to precisely control the protein production (the genes) in cells, have promptly being proposed to be implicated in different pathologies such as different types of cancers and recent scientific studies have proven their roles. The contribution of theses tiny molecules to our understanding of the cell, as well as their great potential in the detection and treatment of different diseases, makes this field of research among the most active in medical biology. His work focuses on the identification of cellular molecules that participate in the biological role of small non-coding RNAs, on understanding their roles and defining their implication in the development of different pathologies, such as cancers. At term, our studies will contribute to gather new insights about how theses tiny molecules contribute to cell function, and to develop new therapeutic strategies using the small non-coding RNAs.

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9, rue McMahon
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Québec, Québec
Canada G1R 2J6
+1 418-525-4444, extension 15185
+1 418-691-5439
Martin.Simard@crchudequeb...

Latest news

52 entries « ‹ 1 of 6 › »

Pal A, Vasudevan V, Houle F, Lantin M, Maniates KA, Huberdeau MQ, Abbott AL, Simard MJ

Defining the contribution of microRNA-specific slicing Argonautes in animals

Journal Article

bioRxiv, 2023.

Abstract | Links:

Quévillon Huberdeau M, Shah VN, Nahar S, Neumeier J, Houle F, Bruckmann A, Gypas F, Nakanishi K, Großhans H, Meister G, Simard MJ

A specific type of Argonaute phosphorylation regulates binding to microRNAs during C. elegans development

Journal Article

Cell Rep, 41 (11), 2022.

Abstract | Links:

Frédérick PM, Simard MJ

Regulation and different functions of the animal microRNA-induced silencing complex

Journal Article

Wiley Interdiscip Rev RNA, 13 (4), 2022.

Abstract | Links:

Michaud P, Shah VN, Adjibade P, Houle F, Quévillon Huberdeau M, Rioux R, Lavoie-Ouellet C, Gu W, Mazroui R, Simard MJ

The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans

Journal Article

PLoS Genet, 17 (4), 2021.

Abstract | Links:

Kakumani PK, Guitart T, Houle F, Harvey LM, Goyer B, Germain L, Gebauer F, Simard MJ

CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma

Journal Article

Oncogene, 40 (18), 2021.

Abstract | Links:

Kakumani PK, Harvey LM, Houle F, Guitart T, Gebauer F, Simard MJ

CSDE1 controls gene expression through the miRNA-mediated decay machinery

Journal Article

Life Sci Alliance, 3 (4), 2020.

Abstract | Links:

Quevillon Huberdeau M, Simard MJ

A guide to microRNA-mediated gene silencing

Journal Article

FEBS J, 286 (4), 2019.

Abstract | Links:

Pal A, Shah VN, Simard MJ

Defend Thyself and Thy Offspring

Journal Article

Dev Cell, 50 (6), 2019.

Abstract | Links:

Zhong L, Huot J, Simard MJ

p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells

Journal Article

Sci Rep, 8 (1), 2018.

Abstract | Links:

Fressigne L, Simard MJ

[Biogenesis of small non-coding RNAs in animals]

Journal Article

Med Sci (Paris), 34 (2), 2018.

Abstract | Links:

52 entries « ‹ 1 of 6 › »
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Active projects

  • Canadian Developmental Biology Conference 2023, from 2021-04-01 to 2023-03-31
  • Deciphering cellular modulators of the microRNA pathway, from 2023-03-01 to 2024-02-29
  • Genetic and molecular analysis of the siRNA-mediated gene regulation, from 2019-04-01 to 2024-03-31
  • Understanding the regulation and implication of Argonaute in microRNA-mediated gene silencing., from 2020-10-01 to 2025-09-30

Recently finished projects

  • Acquisition d'un appareil PCR pour analyses d'échantillons biologiques , from 2021-07-16 to 2022-07-15
  • Étude de la régulation des gènes par les courts ARNs non-codants, from 2017-07-01 to 2021-06-30
  • Functional dissection of the microRNA pathway., from 2015-07-01 to 2021-03-31
Data provided by the Université Laval research projects registery