Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.

Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.

Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.

202 entries « 2 of 21 »

St-Pierre MK, Carrier M, González Ibáñez F, Khakpour M, Wallman MJ, Parent M, Tremblay MÈ

Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples

Journal Article

J Neuroinflammation, 20 (1), 2023.

Abstract | Links:

Garofalo S, Cocozza G, Mormino A, Bernardini G, Russo E, Ielpo D, Andolina D, Ventura R, Martinello K, Renzi M, Fucile S, Laffranchi M, Mortari EP, Carsetti R, Sciumè G, Sozzani S, Santoni A, Tremblay ME, Ransohoff RM, Limatola C

Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine

Journal Article

Nat Commun, 14 (1), 2023.

Abstract | Links:

Plemel JR, Rosin JM, Tremblay MÈ

Editorial: Insights in non-neuronal cells: 2021

Journal Article

Front Cell Neurosci, 17 , 2023.

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Stratoulias V, Ruiz R, Kanatani S, Osman AM, Keane L, Armengol JA, Rodríguez-Moreno A, Murgoci AN, García-Domínguez I, Alonso-Bellido I, González Ibáñez F, Picard K, Vázquez-Cabrera G, Posada-Pérez M, Vernoux N, Tejera D, Grabert K, Cheray M, González-Rodríguez P, Pérez-Villegas EM, Martínez-Gallego I, Lastra-Romero A, Brodin D, Avila-Cariño J, Cao Y, Airavaara M, Uhlén P, Heneka MT, Tremblay MÈ, Blomgren K, Venero JL, Joseph B

ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain

Journal Article

Nat Neurosci, 26 (6), 2023.

Abstract | Links:

Murray CJ, Vecchiarelli HA, Tremblay MÈ

Enhancing axonal myelination in seniors: A review exploring the potential impact cannabis has on myelination in the aged brain

Journal Article

Front Aging Neurosci, 15 , 2023.

Abstract | Links:

McKee CG, Hoffos M, Vecchiarelli HA, Tremblay MÈ

Microglia: A pharmacological target for the treatment of age-related cognitive decline and Alzheimer's disease

Journal Article

Front Pharmacol, 14 , 2023.

Abstract | Links:

Dermitzakis I, Manthou ME, Meditskou S, Tremblay MÈ, Petratos S, Zoupi L, Boziki M, Kesidou E, Simeonidou C, Theotokis P

Origin and Emergence of Microglia in the CNS-An Interesting (Hi)story of an Eccentric Cell

Journal Article

Curr Issues Mol Biol, 45 (3), 2023.

Abstract | Links:

VanderZwaag J, Halvorson T, Dolhan K, Šimončičová E, Ben-Azu B, Tremblay MÈ

The Missing Piece? A Case for Microglia's Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics

Journal Article

Neurochem Res, 48 (4), 2023.

Abstract | Links:

Béland-Millar A, Kirby A, Truong Y, Ouellette J, Yandiev S, Bouyakdan K, Pileggi C, Naz S, Yin M, Carrier M, Kotchetkov P, St-Pierre MK, Tremblay MÈ, Courchet J, Harper ME, Alquier T, Messier C, Shuhendler AJ, Lacoste B

16p11.2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice

Journal Article

Cell Rep, 42 (5), 2023.

Abstract | Links:

St-Pierre MK, Šimončičová E, Carrier M, Tremblay MÈ

Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electron Microscopy Images

Journal Article

Methods Mol Biol, 2561 , 2023.

Abstract | Links:

202 entries « 2 of 21 »
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