Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.
Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.
Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.
- Carrier, MicaëlDoctoral studentCHUL+1 418-525-4444, extension 48724micael.carrier.1@ulaval.camicael.carrier@crchudequebec.ulaval.ca
2705, Boul. Laurier
P-09803
Québec, QC
Canada G1V 4G2 - Gonzalez Ibanez, FernandoDoctoral studentCHUL+1 418-525-4444, extension 48724fernando.gonzalez-ibanez.1@ulaval.cafernando.gonzalez-ibanez@crchudequebec.ulaval.ca
2705, Boul. Laurier
P-09803
Québec, QC
Canada G1V 4G2 - St-Pierre, Marie-KimDoctoral studentCHUL+1 418-525-4444, extension 48724marie-kim.st-pierre.1@ulaval.camarie-kim.st-pierre@crchudequebec.ulaval.ca
2705, boul. Laurier
P-09803
Québec, QC
Canada G1V 4G2
Ketogenic diet alters microglial morphology and changes the hippocampal lipidomic profile distinctively in stress susceptible versus resistant male mice upon repeated social defeat
Journal ArticlebioRxiv, 2023.
Ketogenic diet changes microglial morphology and the hippocampal lipidomic profile differently in stress susceptible versus resistant male mice upon repeated social defeat
Journal ArticleBrain Behav Immun, 114 , 2023.
Microglial contribution to the pathology of neurodevelopmental disorders in humans
Journal ArticleActa Neuropathol, 2023.
Sex differences of microglia in the healthy brain from embryonic development to adulthood and across lifestyle influences
Journal ArticleBrain Res Bull, 202 , 2023.
A review of the auditory-gut-brain axis
Journal ArticleFront Neurosci, 17 , 2023.
Disrupting T cell memory to promote stress resilience: A role for CD74
Journal ArticleBrain Behav Immun, 114 , 2023.
Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation
Journal ArticleNat Commun, 14 (1), 2023.
TSPO PET brain inflammation imaging: A transdiagnostic systematic review and meta-analysis of 156 case-control studies
Journal ArticleBrain Behav Immun, 113 , 2023.
Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID-19 symptoms and myalgic encephalomyelitis/chronic fatigue syndrome
Journal ArticleBrain Res Bull, 201 , 2023.
Microglial Transcriptional Signatures in the Central Nervous System: Toward A Future of Unraveling Their Function in Health and Disease
Journal ArticleAnnu Rev Genet, 2023.
Active projects
- Nutrition and brain health, from predictive biology to disease prevention and treatment - Food4BrainHealth, from 2019-03-18 to 2024-03-17
Recently finished projects
- MICROGLIA-SYNAPSE INTERACTIONS: THEIR ROLES IN THE BRAIN’S ADAPTATION TO ENVIRONMENTAL CHALLENGES., from 2014-04-01 to 2022-03-31
- Microglial control of synaptic function in stress response and vulnerability to depression, from 2018-05-15 to 2021-05-14
- Role of developing hippocampus in organizing prefrontal cortical functions, from 2015-07-01 to 2021-03-31