Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.

Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.

Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.

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Ghorbani S, Li C, Lozinski BM, Moezzi D, D'Mello C, Dong Y, Visser F, Li H, Silva C, Khakpour M, Murray CJ, Tremblay MÈ, Xue M, Yong VW

Fibulin-2 is an extracellular matrix inhibitor of oligodendrocytes relevant to multiple sclerosis

Journal Article

J Clin Invest, 2024.

Abstract | Links:

Carrier M, Hui CW, Watters V, Šimončičová E, Picard K, González Ibáñez F, Vernoux N, Droit A, Desjardins M, Tremblay MÈ

Behavioral as well as hippocampal transcriptomic and microglial responses differ across sexes in adult mouse offspring exposed to a dual genetic and environmental challenge

Journal Article

Brain Behav Immun, 116 , 2024.

Abstract | Links:

Lounas A, Breton Y, Lebrun A, Laflamme I, Vernoux N, Savage J, Tremblay MÈ, Pelletier M, Germain M, Richard FJ

The follicle-stimulating hormone triggers rapid changes in mitochondrial structure and function in porcine cumulus cells

Journal Article

Sci Rep, 14 (1), 2024.

Abstract | Links:

Thébault SC, Tremblay MÈ, Conde SV, González-González MA

Editorial: Women in neuroscience of Bioelectronic Medicine

Journal Article

Front Integr Neurosci, 18 , 2024.

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Balestri W, Sharma R, da Silva VA, Bobotis BC, Curle AJ, Kothakota V, Kalantarnia F, Hangad MV, Hoorfar M, Jones JL, Tremblay MÈ, El-Jawhari JJ, Willerth SM, Reinwald Y

Modeling the neuroimmune system in Alzheimer's and Parkinson's diseases

Journal Article

J Neuroinflammation, 21 (1), 2024.

Abstract | Links:

Newman LE, Weiser Novak S, Rojas GR, Tadepalle N, Schiavon CR, Grotjahn DA, Towers CG, Tremblay MÈ, Donnelly MP, Ghosh S, Medina M, Rocha S, Rodriguez-Enriquez R, Chevez JA, Lemersal I, Manor U, Shadel GS

Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal

Journal Article

Nat Cell Biol, 26 (2), 2024.

Abstract | Links:

Chaves-Filho A, Eyres C, Blöbaum L, Landwehr A, Tremblay MÈ

The emerging neuroimmune hypothesis of bipolar disorder: An updated overview of neuroimmune and microglial findings

Journal Article

J Neurochem, 2024.

Abstract | Links:

González-González MA, Conde SV, Latorre R, Thébault SC, Pratelli M, Spitzer NC, Verkhratsky A, Tremblay MÈ, Akcora CG, Hernández-Reynoso AG, Ecker M, Coates J, Vincent KL, Ma B

Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies

Journal Article

Front Integr Neurosci, 18 , 2024.

Abstract | Links:

Iovino L, VanderZwaag J, Kaur G, Khakpour M, Giusti V, Donadon M, Chiavegato A, Tenorio-Lopes L, Greggio E, Tremblay ME, Civiero L

Investigation of microglial diversity in a LRRK2 G2019S mouse model of Parkinson's disease

Journal Article

Neurobiol Dis, 195 , 2024.

Abstract | Links:

Bobotis BC, Halvorson T, Carrier M, Tremblay MÈ

Established and emerging techniques for the study of microglia: visualization, depletion, and fate mapping

Journal Article

Front Cell Neurosci, 18 , 2024.

Abstract | Links:

202 entries « 1 of 21 »
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