Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.

Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.

Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.

142 entries « 1 of 15 »

Gonçalves de Andrade E, González Ibáñez F, Tremblay MÈ

Microglia as a Hub for Suicide Neuropathology: Future Investigation and Prevention Targets

Journal Article

Front Cell Neurosci, 16 , 2022.

Abstract | Links:

Renz-Polster H, Tremblay ME, Bienzle D, Fischer JE

The Pathobiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Case for Neuroglial Failure

Journal Article

Front Cell Neurosci, 16 , 2022.

Abstract | Links:

Uyar O, Dominguez JM, Bordeleau M, Lapeyre L, Ibáñez FG, Vallières L, Tremblay ME, Corbeil J, Boivin G

Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response

Journal Article

J Neuroinflammation, 19 (1), 2022.

Abstract | Links:

Bolton JL, Short AK, Othy S, Kooiker CL, Shao M, Gunn BG, Beck J, Bai X, Law SM, Savage JC, Lambert JJ, Belelli D, Tremblay MÈ, Cahalan MD, Baram TZ

Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses

Journal Article

Cell Rep, 38 (13), 2022.

Abstract | Links:

Guma E, Bordeleau M, González Ibáñez F, Picard K, Snook E, Desrosiers-Grégoire G, Spring S, Lerch JP, Nieman BJ, Devenyi GA, Tremblay ME, Chakravarty MM

Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment

Journal Article

Proc Natl Acad Sci U S A, 119 (12), 2022.

Abstract | Links:

Bérard M, Sheta R, Malvaut S, Rodriguez-Aller R, Teixeira M, Idi W, Turmel R, Alpaugh M, Dubois M, Dahmene M, Salesse C, Lamontagne-Proulx J, St-Pierre MK, Tavassoly O, Luo W, Del Cid-Pellitero E, Qazi R, Jeong JW, Durcan TM, Vallières L, Tremblay ME, Soulet D, Lévesque M, Cicchetti F, Fon EA, Saghatelyan A, Oueslati A

A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease

Journal Article

PLoS Biol, 20 (3), 2022.

Abstract | Links:

Decoeur F, Picard K, St-Pierre MK, Greenhalgh AD, Delpech JC, Sere A, Layé S, Tremblay ME, Nadjar A

N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice

Journal Article

Front Cell Neurosci, 16 , 2022.

Abstract | Links:

Tremblay ME, Madore C, Tian L, Verkhratsky A

Editorial: Role of Neuroinflammation in the Neuropsychiatric and Neurological Aspects of COVID-19

Journal Article

Front Cell Neurosci, 16 , 2022.

| Links:

Morissette M, Bourque M, Tremblay MÈ, Di Paolo T

Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys

Journal Article

Cells, 11 (4), 2022.

Abstract | Links:

Bordeleau M, Comin CH, Fernández de Cossío L, Lacabanne C, Freitas-Andrade M, González Ibáñez F, Raman-Nair J, Wakem M, Chakravarty M, Costa LDF, Lacoste B, Tremblay MÈ

Maternal high-fat diet in mice induces cerebrovascular, microglial and long-term behavioural alterations in offspring

Journal Article

Commun Biol, 5 (1), 2022.

Abstract | Links:

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Active projects

  • Nutrition and brain health, from predictive biology to disease prevention and treatment - Food4BrainHealth, from 2019-03-18 to 2024-03-17

Recently finished projects

  • Mechanisms of therapeutic efficacy of deep brain stimulation in Parkinson's disease, from 2015-07-01 to 2020-06-30
  • MICROGLIA-SYNAPSE INTERACTIONS: THEIR ROLES IN THE BRAIN’S ADAPTATION TO ENVIRONMENTAL CHALLENGES., from 2014-04-01 to 2022-03-31
  • Microglial control of synaptic function in stress response and vulnerability to depression, from 2018-05-15 to 2021-05-14
  • Role of developing hippocampus in organizing prefrontal cortical functions, from 2015-07-01 to 2021-03-31
Data provided by the Université Laval research projects registery