Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.
Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.
Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.
- Carrier, MicaëlDoctoral studentCHUL+1 418-525-4444, extension 48724micael.carrier.1@ulaval.camicael.carrier@crchudequebec.ulaval.ca
2705, Boul. Laurier
P-09803
Québec, QC
Canada G1V 4G2 - Delmas, ConstantinDoctoral studentconstantin.delmas.1@ulaval.ca
- Gonzalez Ibanez, FernandoDoctoral studentCHUL+1 418-525-4444, extension 48724fernando.gonzalez-ibanez.1@ulaval.cafernando.gonzalez-ibanez@crchudequebec.ulaval.ca
2705, Boul. Laurier
P-09803
Québec, QC
Canada G1V 4G2 - Picard, KatherineDoctoral studentCHUL+1 418-525-4444, extension 48724katherine.picard.1@ulaval.cakatherine.picard@crchudequebec.ulaval.ca
2705, Boul. Laurier
P-09803
Québec, QC
Canada G1V 4G2 - St-Pierre, Marie-KimDoctoral studentCHUL+1 418-525-4444, extension 48724marie-kim.st-pierre.1@ulaval.camarie-kim.st-pierre@crchudequebec.ulaval.ca
2705, boul. Laurier
P-09803
Québec, QC
Canada G1V 4G2
Microglia as a Hub for Suicide Neuropathology: Future Investigation and Prevention Targets
Journal ArticleFront Cell Neurosci, 16 , 2022.
The Pathobiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Case for Neuroglial Failure
Journal ArticleFront Cell Neurosci, 16 , 2022.
Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response
Journal ArticleJ Neuroinflammation, 19 (1), 2022.
Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses
Journal ArticleCell Rep, 38 (13), 2022.
Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment
Journal ArticleProc Natl Acad Sci U S A, 119 (12), 2022.
A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease
Journal ArticlePLoS Biol, 20 (3), 2022.
N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice
Journal ArticleFront Cell Neurosci, 16 , 2022.
Editorial: Role of Neuroinflammation in the Neuropsychiatric and Neurological Aspects of COVID-19
Journal ArticleFront Cell Neurosci, 16 , 2022.
Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys
Journal ArticleCells, 11 (4), 2022.
Maternal high-fat diet in mice induces cerebrovascular, microglial and long-term behavioural alterations in offspring
Journal ArticleCommun Biol, 5 (1), 2022.
Active projects
- Nutrition and brain health, from predictive biology to disease prevention and treatment - Food4BrainHealth, from 2019-03-18 to 2024-03-17
Recently finished projects
- Mechanisms of therapeutic efficacy of deep brain stimulation in Parkinson's disease, from 2015-07-01 to 2020-06-30
- MICROGLIA-SYNAPSE INTERACTIONS: THEIR ROLES IN THE BRAIN’S ADAPTATION TO ENVIRONMENTAL CHALLENGES., from 2014-04-01 to 2022-03-31
- Microglial control of synaptic function in stress response and vulnerability to depression, from 2018-05-15 to 2021-05-14
- Role of developing hippocampus in organizing prefrontal cortical functions, from 2015-07-01 to 2021-03-31