Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.
Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.
Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.
- Carrier, MicaëlDoctoral studentCHUL+1 418-525-4444, extension 48724micael.carrier.1@ulaval.camicael.carrier@crchudequebec.ulaval.ca
2705, Boul. Laurier
P-09803
Québec, QC
Canada G1V 4G2 - Delmas, ConstantinDoctoral studentconstantin.delmas.1@ulaval.ca
- Gonzalez Ibanez, FernandoDoctoral studentCHUL+1 418-525-4444, extension 48724fernando.gonzalez-ibanez.1@ulaval.cafernando.gonzalez-ibanez@crchudequebec.ulaval.ca
2705, Boul. Laurier
P-09803
Québec, QC
Canada G1V 4G2 - Picard, KatherineDoctoral studentCHUL+1 418-525-4444, extension 48724katherine.picard.1@ulaval.cakatherine.picard@crchudequebec.ulaval.ca
2705, Boul. Laurier
P-09803
Québec, QC
Canada G1V 4G2 - St-Pierre, Marie-KimDoctoral studentCHUL+1 418-525-4444, extension 48724marie-kim.st-pierre.1@ulaval.camarie-kim.st-pierre@crchudequebec.ulaval.ca
2705, boul. Laurier
P-09803
Québec, QC
Canada G1V 4G2
Editorial: Insights in non-neuronal cells: 2021
Journal ArticleFront Cell Neurosci, 17 , 2023.
ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain
Journal ArticleNat Neurosci, 2023.
16p11.2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice
Journal ArticleCell Rep, 42 (5), 2023.
Enhancing axonal myelination in seniors: A review exploring the potential impact cannabis has on myelination in the aged brain
Journal ArticleFront Aging Neurosci, 15 , 2023.
Microglia: A pharmacological target for the treatment of age-related cognitive decline and Alzheimer's disease
Journal ArticleFront Pharmacol, 14 , 2023.
Origin and Emergence of Microglia in the CNS-An Interesting (Hi)story of an Eccentric Cell
Journal ArticleCurr Issues Mol Biol, 45 (3), 2023.
The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring
Journal ArticleDev Neurosci, 2023.
An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer's disease
Journal ArticleNat Commun, 14 (1), 2023.
Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples
Journal ArticleJ Neuroinflammation, 20 (1), 2023.
Minocycline treatment improves cognitive and functional plasticity in a preclinical mouse model of major depressive disorder
Journal ArticleBehav Brain Res, 441 , 2023.
Active projects
- Nutrition and brain health, from predictive biology to disease prevention and treatment - Food4BrainHealth, from 2019-03-18 to 2024-03-17
Recently finished projects
- MICROGLIA-SYNAPSE INTERACTIONS: THEIR ROLES IN THE BRAIN’S ADAPTATION TO ENVIRONMENTAL CHALLENGES., from 2014-04-01 to 2022-03-31
- Microglial control of synaptic function in stress response and vulnerability to depression, from 2018-05-15 to 2021-05-14
- Role of developing hippocampus in organizing prefrontal cortical functions, from 2015-07-01 to 2021-03-31