I am an associate professor in the department of Microbiology-Infectiology and Immunology, at the Laval University School of Medicine, and a member of the Infectious Diseases and Immunology Axis of the CHUQ Research Center, CHUL Pavilion.

I did my PhD at McGill University in molecular genetics and my post-doctoral studies at Thomas Jefferson University (Philadelphia) in cancer, during which I cloned two new genes that code for C-type lectin receptors. During my subsequent post-doctoral work at Laval University, my research focused on neutrophil biology, and specifically on signaling. The current research in my laboratory brings together these three fields of research, namely, genetics, C-type lectin receptors, and innate immunity.

The overall goal of the research in my laboratory is to further our understanding of the immunopathogenesis of two types of arthritis, namely rheumatoid arthritis and gout. Arthritis refers to a group of diseases that affect the joints and cause pain and inflammation. There are over 100 types of arthritis. Although drugs are available to treat different types of arthritis, many medications are associated with secondary side effects, and some patients don’t respond to available drugs. To address this unmet need, we must gain more insight into the pathogenesis of these diseases to develop more effective and less toxic drugs.

Our research revealed that the C-type lectin receptor known as Clec12A is involved in the pathogenesis of rheumatoid arthritis and gout. This discovery provides insight into one of the mechanisms through which the immune system is deregulated in these diseases. Clec12A is an inhibitory receptor that is expressed by the innate immune cells of the myeloid lineage, such as neutrophils and monocytes. It is also expressed by dendritic cells. Our current working hypothesis is that in gout and rheumatoid arthritis, the Clec12A inhibitory pathway is not fully functional, causing myeloid cells to be more easily activated.

We use a multidisciplinary approach to gain insight into how Clec12A works to determine its contribution to the pathogenesis of arthritis, with the goal of eventually transferring our findings to clinical practice. The molecular and cellular biology tools we use will shed light on how Cle12A dampens the activation of immune cells. To complement this line of research, the more clinical aspect of our Clec12A project involves the analysis of patient samples to better understand the potential role of this inhibitor in chronic inflammatory diseases (e.g.: gout and rheumatoid arthritis).

Another aspect of our research involves the development of a new anti-inflammatory drug to treat gout, using a rational drug design approach. This new drug may also have the ability to dampen inflammation in patients suffering from other inflammatory diseases.

In summary, our research aims to further our understanding of the pathogenesis of gout and rheumatoid arthritis, identify biomarkers for these diseases, as well as develop a new anti-inflammatory drug that is less toxic and more potent than those used to currently treat gout and other chronic inflammatory diseases. The results of this research will also shed light on the role of Clec12A in other chronic inflammatory diseases, since the Clec12A pathways also seem to be dysregulated in Crohn’s disease.

2705, boulevard Laurier
Québec, Québec
Canada G1V 4G2
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Naccache P, Fernandes MJ

Challenges in the characterization of neutrophil extracellular traps: The truth is in the details

Journal Article

Eur J Immunol, 46 (1), 2016.

Abstract | Links:

Redelinghuys P, Whitehead L, Augello A, Drummond RA, Levesque JM, Vautier S, Reid DM, Kerscher B, Taylor JA, Nigrovic PA, Wright J, Murray GI, Willment JA, Hocking LJ, Fernandes MJ, De Bari C, Mcinnes IB, Brown GD

MICL controls inflammation in rheumatoid arthritis

Journal Article

Ann Rheum Dis, 75 (7), 2016.

Abstract | Links:

Zhao C, Moreno-Nieves U, Di Battista JA, Fernandes MJ, Touaibia M, Bourgoin SG

Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts

Journal Article

Mediators Inflamm, 2015 , 2015.

Abstract | Links:

Charest-Morin X, Roy C, Fernandes MJ, Marceau F

Pharmacological profile of a bifunctional ligand of the formyl peptide receptor1 fused to the myc epitope

Journal Article

Int Immunopharmacol, 25 (1), 2015.

Abstract | Links:

Zhao C, Sardella A, Davis L, Poubelle PE, Bourgoin SG, Fernandes MJ

A transgenic mouse model for the in vivo bioluminescence imaging of the expression of the lysophosphatidic acid receptor 3: relevance for inflammation and uterine physiology research

Journal Article

Transgenic Res, 24 (4), 2015.

Abstract | Links:

Zhao C, Hui W, Fernandes MJ, Poubelle PE, Bourgoin SG

Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes

Journal Article

Biochem Pharmacol, 90 (1), 2014.

Abstract | Links:

Gagne V, Marois L, Levesque JM, Galarneau H, Lahoud MH, Caminschi I, Naccache PH, Tessier P, Fernandes MJ

Modulation of monosodium urate crystal-induced responses in neutrophils by the myeloid inhibitory C-type lectin-like receptor: potential therapeutic implications

Journal Article

Arthritis Res Ther, 15 (4), 2013.

Abstract | Links:

Roy C, Gagne V, Fernandes MJ, Marceau F

High affinity capture and concentration of quinacrine in polymorphonuclear neutrophils via vacuolar ATPase-mediated ion trapping: comparison with other peripheral blood leukocytes and implications for the distribution of cationic drugs

Journal Article

Toxicol Appl Pharmacol, 270 (2), 2013.

Abstract | Links:

Bourgoin SG, Zhao C, Fernandes MJ

Targeting the metabolism and receptors of sphingosine-1- phosphate for the treatment of rheumatoid arthritis

Book Chapter

Lemmey A (Ed.): Rheumatoid Arthritis - Treatment, pp. 195-210, Rijeka, InTech, 2012, ISBN: 9789533078502.

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Michou L, Cornelis F, Levesque JM, Bombardieri S, Balsa A, Westhovens R, Barrera P, Alves H, van de Putte L, Migliorini P, Bardin T, Petit-Teixeira E, Fernandes MJ

A genetic association study of the CLEC12A gene in rheumatoid arthritis

Journal Article

Joint Bone Spine, 79 (5), 2012.

Abstract | Links:

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Active projects

  • Cryopreservation of human neutrophils as a source of innate immune defenses for neutropenicpatients with life-threatening infections - Soutien facultaire, from 2023-04-01 to 2024-03-31
  • Évaluation d’un nouvel auto-anticorps dans l'arthrite rhumatoïde comme biomarqueur potentiel, from 2022-10-01 to 2023-09-30
  • FGR - Caractérisation du rôle des microtubules (MT) dans les neutrophiles, from 2022-09-20 to 2023-09-19
  • Le rôle inhibiteur de CLEC12A dans lesmaladies autoimmunes : complexes immuns et neutrophiles, from 2023-05-08 to 2023-09-30
  • Optimisation de l'efficacité antimicrobienne des dons de granulocytes destinés à la transfusion, from 2021-09-01 to 2023-10-31

Recently finished projects

  • Caractérisation de la viabilité et de la fonction des granulocytes destinés à la transfusion, from 2019-09-15 to 2021-11-14
  • Développement d'une nouvelle drogue anti-inflammatoire qui est moins toxique et plus efficace que la colchicine , from 2020-06-09 to 2023-03-31
  • Évaluation d'un nouvel anti-corps dans l'arthrite rhumatoïde comme biomarqueur potentiel, from 2022-07-11 to 2023-03-31
  • Les transfusions de granulocytes: l'optimisation de l'entreposage des concentrés de granulocytes et le rôle antimicrobien des monocytes, from 2021-04-01 to 2022-03-31
  • Subvention d'appariement à la programmation de recherche, from 2020-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery