Dr. Marc Pouliot is a Full Professor in the Department of Microbiology-Infectious Diseases and Immunology, of the Laval University School of Medicine, leading a knowledge development program on the implication of neutrophils in inflammatory responses. After completing his Ph.D in 1994 in molecular biology at Laval University, under the supervision of Dr. Pierre-Borgeat, Dr. Pouliot specialized in immunology during two postdoctoral fellowships, at the Royal Adelaide Hospital (South Australia), and then at the Brigham and Women’s Hospital (Harvard Medical School, Boston, USA), he joined in 2000 (Full professor since 2009). He was awarded competitive scholarships, continuously from Master’s degree to Senior Investigator level, from: Fonds canadien pour l’avancement de la recherche (Masters); Fonds de la Recherche en Santé du Québec (Ph.D.); Medical Research Council (Post-doc, and Centennial Distinguished Post-doc awards); Canadian Pain Society, Banting Research Foundation, CAN, TAS and CIHR (New Investigator & Investigator); and from FRSQ (Junior & Senior Investigator). As PI, he has been funded by the Canadian Institutes of Health Research (CIHR) for the last 17 years, and by The Arthritis Society (TAS), the Canadian Arthritis Network (CAN; a National Center of Excellence), the National Institutes of Health (US), and the Canadian Foundation for Innovation (CFI). Some career numbers: Peer-reviewed publications: 53, Book chapters: 5, h index: 25 (2394 citations, 882 since 2012), i10 index: 33 (Google Scholar), Funding (as PI): >2M$. He has supervised 4 post-docs, 30 graduate students and trainees, and has reviewed more than 45 Ph.D. theses and Master’s memoirs.

Adenosine & neutrophils

Dr. Pouliot’s research program focusses on extricating the full worth of neutrophils in innate immunity. He and his team have contributed to show that neutrophils can produce a tightly regulated array of mediators, including eicosanoids, cytokines, and chemokines, that can influence each of the phases of an inflammatory response. His team showed that engagement of the adenosine A2A receptor represents a master key in re-programming neutrophils, on one hand by shifting their leukotriene B4-generating capacity toward prostaglandin E2 instead, and on the other hand, by preventing the generation of inflammatory cytokines, including TNF. How A2A receptor engagement can favour the resolution phase of inflammation through its actions on neutrophils has raised considerable interest, exemplified by invited oral presentations during: the 6th World Congress on Inflammation (WCI, Vancouver), at the 8th WCI (Copenhagen), the Purines Congress (Copenhagen), the opening session of the Banff Inflammation Workshop, the 9th WCI (Tokyo), the joint SLB and Neutrophil 2016 in Verona (Italy) and, most recently, the 13th WCI (July 2017, London, UK).

Transcriptome profiling

Twice funded by the CFI (Leaders Fund) with which state-of-the-art, medium throughput, quantitative real-time PCR systems were acquire for the research program. The team can now exploit sections of neutrophils’ transcriptomes and of other tissues to characterize their activation profile (Boudreau et al., 2014; Duchez et al., 2015; Laflamme et al., 2014) and use distinctive alterations therein for diagnostic purposes. Dr. Pouliot was invited present this emerging piece of work at « The Society for Leukocyte Biology’s 49th Annual Meeting, in Verona (Italy) in September of 2016.

2705, boulevard Laurier
Québec, Québec
Canada G1V 4G2
53 entries « 3 of 6 »

St-Onge M, Lagarde S, Laflamme C, Rollet-Labelle E, Marois L, Naccache PH, Pouliot M

Proteinase-activated receptor-2 up-regulation by Fcgamma-receptor activation in human neutrophils

Journal Article

FASEB J, 24 (6), 2010.

Abstract | Links:

Dumas A, Pouliot M

[Neutrophil: foe or friend?]

Journal Article

Med Sci (Paris), 25 (8-9), 2009.

Abstract | Links:

St-Onge M, Dumas A, Michaud A, Laflamme C, Dussault AA, Pouliot M

Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: unraveling endogenous resolution pathways

Journal Article

PLoS One, 4 (3), 2009.

Abstract | Links:

Leclerc P, Biarc J, St-Onge M, Gilbert C, Dussault AA, Laflamme C, Pouliot M

Nucleobindin co-localizes and associates with cyclooxygenase (COX)-2 in human neutrophils

Journal Article

PLoS One, 3 (5), 2008.

Abstract | Links:

Oh DY, Taube S, Hamouda O, Kucherer C, Poggensee G, Jessen H, Eckert JK, Neumann K, Storek A, Pouliot M, Borgeat P, Oh N, Schreier E, Pruss A, Hattermann K, Schumann RR

A functional toll-like receptor 8 variant is associated with HIV disease restriction

Journal Article

J Infect Dis, 198 (5), 2008.

Abstract | Links:

Pouliot M

Adenosine and neutrophil functions

Book Chapter

Haskó G, Cronstein BN, Szabó C (Ed.): Adenosine receptors : therapeutic aspects for inflammatory and immune diseases, pp. 89-100, Boca Raton, FL, CRC/Taylor & Francis, 2007, ISBN: 9780849339998.

St-Onge M, Pouliot M

Neutrophilsand pain : dialogue with the nervous system

Book Chapter

Girard D (Ed.): Phenotypic and functional changes of neutrophils activated by recently identified modulators, pp. 99-120, Trivandrum, Kerala, India, Research Signpost, 2007, ISBN: 9788130801568.

Hattermann K, Picard S, Borgeat M, Leclerc P, Pouliot M, Borgeat P

The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis

Journal Article

FASEB J, 21 (7), 2007.

Abstract | Links:

St-Onge M, Flamand N, Biarc J, Picard S, Bouchard L, Dussault AA, Laflamme C, James MJ, Caughey GE, Cleland LG, Borgeat P, Pouliot M

Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils

Journal Article

Biochim Biophys Acta, 1771 (9), 2007.

Abstract | Links:

Dussault AA, Pouliot M

Rapid and simple comparison of messenger RNA levels using real-time PCR

Journal Article

Biol Proced Online, 8 , 2006.

Abstract | Links:

53 entries « 3 of 6 »
Signaler des ajouts ou des modifications

Active projects

  • FcgRI as a potential therapeutic target in inflammatory arthritis, from 2022-01-01 to 2025-03-31

Recently finished projects

  • Defective prostaglandin biosynthesis pathways and abnormal crosstalk at the endometrial/peritoneal interface: role in the pathophysiology of endometriosis., from 2012-10-01 to 2023-03-31
  • Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1, from 2021-12-01 to 2022-11-30
  • Understanding the pathogenesis of COVID-19, from 2020-03-01 to 2023-02-28
Data provided by the Université Laval research projects registery

Current extramural services: Laval University Delegate at CIHR; Member of the CIHR College of reviewers; Reviewer for Projects scheme (CIHR); On the editorial board of 6 journals. Until recently: Co-Chair of the Institute Advisory Board, Institute of Musculoskeletal Health and Arthritis (IMHA) at CIHR; Chair, Scientific Advisory Board, The Arthritis Society (TAS); Co-Chair, training and education committee, Canadian Arthritis Network (CAN), SO, or regular member of CIHR, CFI, AHFMR and TAS/CAN review committees.

Recent international outreach activities

  • Invited speaker: "Early tyrosine phosphorylation and comparative proteomics provide new insights into adenosine A2A receptor activities in human neutrophils", The Society for leukocyte biology's 49th annual meeting, Verona ITALIE, 2016-09-15 to 2016-09-17

Recent national outreach activities

  • Member of the evaluation comittee: Compétition "projets" stages 1 et 2, IRSC, , 2017 to 2017
  • CIHR: Institutional Advisory Board (IAB), IMHA. Regular Member, , , 2011-09-01 to 2016-06-01
  • Member of the evaluation comittee: La Société d'arthrite du Canada, , , Since 2002-01-01