Dr. Marc Ouellette is an investigator at the Infectious Diseases and Immunity Axis of the Research Centre of the CHU de Québec-Laval University. He is also a full professor at the Department of Microbiology-Infectious Diseases and Immunology at the Laval University School of Medicine. His work focuses on antimicrobial resistance. Dr. Ouellette holds a Canada Research Chair in antimicrobial resistance and was the Scientific Director of the CIHR Institute of Infection and Immunity from 2010-2018. He is a fellow of the Royal Society of Canada and of the Canadian Academy of Health Sciences.

Dr. Ouelette’s work focuses on the protozoan parasite Leishmania and on different bacteria, including the pneumococcus. Leishmania is a neglected tropical disease that affects over 12 million people, while antibiotic resistance is a major public health issue that is receiving unprecedented political attention. His team uses several screens coupled to next-generation sequencing to find novel biomarkers of resistance in parasites and bacteria. Their screens are also used to identify new drug cellular targets against new molecules or also to define death and survival pathways that could be exploited for novel therapeutic strategies.

CHUL
2705, boulevard Laurier
R-0709
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 48184 / 42750
+1 418-654-2715
marc.ouellette@crchudeque...

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Papadopoulou B, Roy G, Dey S, Rosen BP, Olivier M, Ouellette M

Gene disruption of the P-glycoprotein related gene pgpa of Leishmania tarentolae

Journal Article

Biochem Biophys Res Commun, 224 (3), 1996.

Abstract | Links:

Ouellette M, Papadopoulou B

Mechanisms of drug resistance in Leishmania

Journal Article

Parasitol Today, 9 (5), 1993.

Abstract | Links:

Papadopoulou B, Roy G, Ouellette M

A novel antifolate resistance gene on the amplified H circle of Leishmania

Journal Article

EMBO J, 11 (10), 1992.

Abstract | Links:

Beaulieu D, Ouellette M, Bergeron MG, Roy PH

Characterization of a plasmid isolated from Branhamella catarrhalis and detection of plasmid sequences within the genome of a B. catarrhalis strain

Journal Article

Plasmid, 20 (2), 1988.

Abstract | Links:

Martel AY, Gosselin P, Ouellette M, Roy PH, Bergeron MG

Isolation and molecular characterization of beta-lactamase-producing Haemophilus parainfluenzae from the genital tract

Journal Article

Antimicrob Agents Chemother, 31 (6), 1987.

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Active projects

  • Chaire de recherche du Canada sur la résistance aux antiantimicrobiens, from 2017-04-01 to 2024-03-31
  • Drug resistance and drug targets in the protozoan parasite Leishmania, from 2019-10-01 to 2024-09-30
  • Genomics of antimicrobial resistance and drug/target discovery, from 2019-07-01 to 2027-06-30
  • Les bactériocines : une alternative naturelle fort prometteuse pour le remplacement des antibiotiques en production avicole., from 2019-04-01 to 2023-06-30

Recently finished projects

  • MAchine learning for diGItal diagnosTICS of antimicrobial resistance, from 2019-10-01 to 2022-09-30
Data provided by the Université Laval research projects registery