Dr. Marc Ouellette is an investigator at the Infectious Diseases and Immunity Axis of the Research Centre of the CHU de Québec-Laval University. He is also a full professor at the Department of Microbiology-Infectious Diseases and Immunology at the Laval University School of Medicine. His work focuses on antimicrobial resistance. Dr. Ouellette holds a Canada Research Chair in antimicrobial resistance and was the Scientific Director of the CIHR Institute of Infection and Immunity from 2010-2018. He is a fellow of the Royal Society of Canada and of the Canadian Academy of Health Sciences.

Dr. Ouelette’s work focuses on the protozoan parasite Leishmania and on different bacteria, including the pneumococcus. Leishmania is a neglected tropical disease that affects over 12 million people, while antibiotic resistance is a major public health issue that is receiving unprecedented political attention. His team uses several screens coupled to next-generation sequencing to find novel biomarkers of resistance in parasites and bacteria. Their screens are also used to identify new drug cellular targets against new molecules or also to define death and survival pathways that could be exploited for novel therapeutic strategies.

CHUL
2705, boulevard Laurier
R-0709
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 48184 / 42750
+1 418-654-2715
marc.ouellette@crchudeque...

Latest news

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Gingras H, Patron K, Leprohon P, Ouellette M

Azithromycin resistance mutations in Streptococcus pneumoniae as revealed by a chemogenomic screen

Journal Article

Microb Genom, 6 (11), 2020.

Abstract | Links:

Douanne N, Wagner V, Roy G, Leprohon P, Ouellette M, Fernandez-Prada C

MRPA-independent mechanisms of antimony resistance in Leishmania infantum

Journal Article

Int J Parasitol Drugs Drug Resist, 13 , 2020.

Abstract | Links:

Ouellette M, Bhattacharya A

Exploiting antimicrobial resistance: Better knowledge of resistance mechanisms can inform the search for and development of new antibiotics

Journal Article

EMBO Rep, 21 (4), 2020.

Abstract | Links:

Van den Kerkhof M, Mabille D, Hendrickx S, Leprohon P, Mowbray CE, Braillard S, Ouellette M, Maes L, Caljon G

Antileishmanial Aminopyrazoles: Studies into Mechanisms and Stability of Experimental Drug Resistance

Journal Article

Antimicrob Agents Chemother, 64 (9), 2020.

Abstract | Links:

El Khoury JY, Maure A, Gingras H, Leprohon P, Ouellette M

Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria

Journal Article

mSystems, 4 (6), 2019.

Abstract | Links:

Bhattacharya A, Sharma M, Pakkinathan C, Rosen BP, Leprohon P, Ouellette M

Genomewide Analysis of Mode of Action of the -Adenosylmethionine Analogue Sinefungin in Leishmania infantum

Journal Article

mSystems, 4 (5), 2019.

Abstract | Links:

Raymond F, Boissinot M, Ouameur AA, Deraspe M, Plante PL, Kpanou SR, Berube E, Huletsky A, Roy PH, Ouellette M, Bergeron MG, Corbeil J

Culture-enriched human gut microbiomes reveal core and accessory resistance genes

Journal Article

Microbiome, 7 (1), 2019.

Abstract | Links:

Bhattacharya A, Leprohon P, Bigot S, Padmanabhan PK, Mukherjee A, Roy G, Gingras H, Mestdagh A, Papadopoulou B, Ouellette M

Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania

Journal Article

Nat Commun, 10 (1), 2019.

Abstract | Links:

Wallace RL, Ouellette M, Jean J

Effect of UV-C light or hydrogen peroxide wipes on the inactivation of methicillin-resistant Staphylococcus aureus, Clostridium difficile spores and norovirus surrogate

Journal Article

J Appl Microbiol, 127 (2), 2019.

Abstract | Links:

Potvin JE, Leprohon P, Gazanion E, Sharma M, Fernandez-Prada C, Ouellette M

Cos-Seq: A High-Throughput Gain-of-Function Screen for Drug Resistance Studies in Leishmania

Journal Article

Methods Mol Biol, 1971 , 2019.

Abstract | Links:

215 entries « ‹ 2 of 22 › »
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Active projects

  • Chaire de recherche du Canada sur la résistance aux antiantimicrobiens, from 2017-04-01 to 2024-03-31
  • Drug resistance and drug targets in the protozoan parasite Leishmania, from 2019-10-01 to 2024-09-30
  • Genomics of antimicrobial resistance and drug/target discovery, from 2019-07-01 to 2027-06-30
  • Les bactériocines : une alternative naturelle fort prometteuse pour le remplacement des antibiotiques en production avicole., from 2019-04-01 to 2023-06-30

Recently finished projects

  • MAchine learning for diGItal diagnosTICS of antimicrobial resistance, from 2019-10-01 to 2022-09-30
Data provided by the Université Laval research projects registery