Dr. Marc Ouellette is an investigator at the Infectious Diseases and Immunity Axis of the Research Centre of the CHU de Québec-Laval University. He is also a full professor at the Department of Microbiology-Infectious Diseases and Immunology at the Laval University School of Medicine. His work focuses on antimicrobial resistance. Dr. Ouellette holds a Canada Research Chair in antimicrobial resistance and was the Scientific Director of the CIHR Institute of Infection and Immunity from 2010-2018. He is a fellow of the Royal Society of Canada and of the Canadian Academy of Health Sciences.
Dr. Ouelette’s work focuses on the protozoan parasite Leishmania and on different bacteria, including the pneumococcus. Leishmania is a neglected tropical disease that affects over 12 million people, while antibiotic resistance is a major public health issue that is receiving unprecedented political attention. His team uses several screens coupled to next-generation sequencing to find novel biomarkers of resistance in parasites and bacteria. Their screens are also used to identify new drug cellular targets against new molecules or also to define death and survival pathways that could be exploited for novel therapeutic strategies.
2705, boulevard Laurier
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- Abdallah, KhaledDoctoral studentCHUL+1 418-525-4444, extension 42750khaled.abdallah.1@ulaval.cakhaled.abdallah@crchudequebec.ulaval.ca
2705, boulevard Laurier
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Canada G1V 4G2
Increased copy number of the target gene squalene monooxygenase as the main resistance mechanism to terbinafine in Leishmania infantum
Journal ArticleInt J Parasitol Drugs Drug Resist, 23 , 2023.
New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens
Journal ArticleAntimicrob Agents Chemother, 67 (8), 2023.
Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection
Journal ArticlePLoS Negl Trop Dis, 17 (6), 2023.
Thiophene derivatives activity against the protozoan parasite Leishmania infantum
Journal ArticleInt J Parasitol Drugs Drug Resist, 21 , 2023.
Distinctive features of the oropharyngeal microbiome in Inuit of Nunavik and correlations of mild to moderate bronchial obstruction with dysbiosis
Journal ArticleSci Rep, 13 (1), 2023.
Corrigendum: Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli
Journal ArticleMicrob Genom, 8 (10), 2022.
Simvastatin Resistance of Leishmania amazonensis Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors
Journal ArticleMicroorganisms, 10 (2), 2022.
Nondegradable Antimicrobial Silver-Based Perovskite
Journal ArticleACS Sustain Chem Eng, 10 (15), 2022.
Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
Journal ArticlePLoS Negl Trop Dis, 15 (4), 2021.
Well-Tolerated Amphotericin B Derivatives That Effectively Treat Visceral Leishmaniasis
Journal ArticleACS Infect Dis, 7 (8), 2021.
Active projects
- Caractérisation d'un traitement anti-buée en milieu médical, from 2023-05-15 to 2025-07-14
- Chaire de recherche du Canada sur la résistance aux antiantimicrobiens, from 2017-04-01 to 2024-03-31
- Genomics of antimicrobial resistance and drug/target discovery, from 2019-07-01 to 2027-06-30
Recently finished projects
- Les bactériocines : une alternative naturelle fort prometteuse pour le remplacement des antibiotiques en production avicole., from 2019-04-01 to 2023-08-31
- MAchine learning for diGItal diagnosTICS of antimicrobial resistance, from 2019-10-01 to 2022-09-30