Dr. Marc Ouellette is an investigator at the Infectious Diseases and Immunity Axis of the Research Centre of the CHU de Québec-Laval University. He is also a full professor at the Department of Microbiology-Infectious Diseases and Immunology at the Laval University School of Medicine. His work focuses on antimicrobial resistance. Dr. Ouellette holds a Canada Research Chair in antimicrobial resistance and was the Scientific Director of the CIHR Institute of Infection and Immunity from 2010-2018. He is a fellow of the Royal Society of Canada and of the Canadian Academy of Health Sciences.

Dr. Ouelette’s work focuses on the protozoan parasite Leishmania and on different bacteria, including the pneumococcus. Leishmania is a neglected tropical disease that affects over 12 million people, while antibiotic resistance is a major public health issue that is receiving unprecedented political attention. His team uses several screens coupled to next-generation sequencing to find novel biomarkers of resistance in parasites and bacteria. Their screens are also used to identify new drug cellular targets against new molecules or also to define death and survival pathways that could be exploited for novel therapeutic strategies.

CHUL
2705, boulevard Laurier
R-0709
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 48184 / 42750+1 418-654-2715
marc.ouellette@crchudeque...

Latest news

225 entries « ‹ 1 of 23 › »

Pham N-P, Gingras H, Godin C, Feng J, Groppi A, Nikolski M, Leprohon P, Ouellette M

Holistic understanding of trimethoprim resistance in Streptococcus pneumoniae using an integrative approach of genome-wide association study, resistance reconstruction, and machine learning

Journal Article

mBio, 15 (9), 2024.

Abstract | Links:

Talebpour C, Fani F, Laliberté-Riverin S, Vaidya R, Salimnia H, Alamdari H, Ouellette M

Long-Term Prevention of Arthroplasty Infections via Incorporation of Activated AgNbO3 Nanoparticles in PMMA Bone Cement

Journal Article

ACS Appl Bio Mater, 7 (6), 2024.

Abstract | Links:

Queffeulou M, Leprohon P, Fernandez-Prada C, Ouellette M, Mejía-Jaramillo AM

CRISPR-Cas9 high-throughput screening to study drug resistance in Leishmania infantum

Journal Article

mBio, 15 (7), 2024.

Abstract | Links:

Asencio C, Hervé P, Morand P, Oliveres Q, Morel CA, Prouzet-Mauleon V, Biran M, Monic S, Bonhivers M, Robinson DR, Ouellette M, Rivière L, Bringaud F, Tetaud E

Streptococcus pyogenes Cas9 ribonucleoprotein delivery for efficient, rapid and marker-free gene editing in Trypanosoma and Leishmania

Journal Article

Mol Microbiol, 121 (6), 2024.

Abstract | Links:

Telhig S, Pham NP, Ben Said L, Rebuffat S, Ouellette M, Zirah S, Fliss I

Exploring the genetic basis of natural resistance to microcins

Journal Article

Microb Genom, 10 (2), 2024.

Abstract | Links:

Talebpour C, Fani F, Salimnia H, Ouellette M, Alamdari H

Growth dynamics of Escherichia coli cells on a surface having AgNbO3 antimicrobial particles

Journal Article

PLoS One, 19 (8), 2024.

Abstract | Links:

Gingras H, Peillard-Fiorente F, Godin C, Patron K, Leprohon P, Ouellette M

New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens

Journal Article

Antimicrob Agents Chemother, 67 (8), 2023.

Abstract | Links:

Bigot S, Leprohon P, Vasquez A, Bhadoria R, Skouta R, Ouellette M

Thiophene derivatives activity against the protozoan parasite Leishmania infantum

Journal Article

Int J Parasitol Drugs Drug Resist, 21 , 2023.

Abstract | Links:

Bigot S, Leprohon P, Ouellette M

Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection

Journal Article

PLoS Negl Trop Dis, 17 (6), 2023.

Abstract | Links:

Potvin JÉ, Fani F, Queffeulou M, Gazanion É, Leprohon P, Ouellette M

Increased copy number of the target gene squalene monooxygenase as the main resistance mechanism to terbinafine in Leishmania infantum

Journal Article

Int J Parasitol Drugs Drug Resist, 23 , 2023.

Abstract | Links:

225 entries « ‹ 1 of 23 › »
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Active projects

  • Caractérisation d'un traitement anti-buée en milieu médical, from 2023-05-15 to 2025-07-14
  • Genomics of antimicrobial resistance and drug/target discovery, from 2019-07-01 to 2027-06-30

Recently finished projects

  • Chaire de recherche du Canada sur la résistance aux antiantimicrobiens, from 2017-04-01 to 2024-03-31
  • Les bactériocines : une alternative naturelle fort prometteuse pour le remplacement des antibiotiques en production avicole., from 2019-04-01 to 2023-08-31
  • MAchine learning for diGItal diagnosTICS of antimicrobial resistance, from 2019-10-01 to 2022-09-30
Data provided by the Université Laval research projects registery