Dr. Marc Ouellette is an investigator at the Infectious Diseases and Immunity Axis of the Research Centre of the CHU de Québec-Laval University. He is also a full professor at the Department of Microbiology-Infectious Diseases and Immunology at the Laval University School of Medicine. His work focuses on antimicrobial resistance. Dr. Ouellette holds a Canada Research Chair in antimicrobial resistance and was the Scientific Director of the CIHR Institute of Infection and Immunity from 2010-2018. He is a fellow of the Royal Society of Canada and of the Canadian Academy of Health Sciences.
Dr. Ouelette’s work focuses on the protozoan parasite Leishmania and on different bacteria, including the pneumococcus. Leishmania is a neglected tropical disease that affects over 12 million people, while antibiotic resistance is a major public health issue that is receiving unprecedented political attention. His team uses several screens coupled to next-generation sequencing to find novel biomarkers of resistance in parasites and bacteria. Their screens are also used to identify new drug cellular targets against new molecules or also to define death and survival pathways that could be exploited for novel therapeutic strategies.
2705, boulevard Laurier
R-0709
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Canada G1V 4G2
- Abdallah, KhaledDoctoral studentCHUL+1 418-525-4444, extension 42750khaled.abdallah@crchudequebec.ulaval.ca
2705, boulevard Laurier
R-0709
Québec, QC
Canada G1V 4G2 - Avoine, SuzanneEmployeeCHUL+1 418-525-4444, extension 42750+1 418-654-2715suzanne.avoine@crchudequebec.ulaval.ca
2705, boulevard Laurier
R-0709
Québec, Québec
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R-0709
Québec, QC
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2705, boulevard Laurier
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Québec, QC
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2705, boulevard Laurier
R-0709
Québec, QC
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Canada G1V 4G2 - Flahaut, Mathilde CannelleDoctoral studentCHUL+1 418-525-4444, extension 47639mathilde-cannelle.flahaut@crchudequebec.ulaval.camathilde.flahaut.1@ulaval.ca
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Québec, Québec
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R-0709
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2705, boulevard Laurier
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Québec, Québec
Canada G1V 4G2 - Peillard Fiorente, FloraDoctoral studentCHUL+1 418-525-4444, extension 42750Flora.Peillard-Fiore@crchudequebec.ulaval.caflora.peillard.1@ulaval.ca
2705 Boulevard Laurier
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Québec, QC
Canada G1V 4G2 - Pham, Nguyen PhuongPostdoctoral fellowCHUL+1 418-525-4444, extension 42750nguyen-phuong.pham@crchudequebec.ulaval.ca
2705 boulevard Laurier
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Québec, Québec
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2705, boulevard Laurier
R-0709
Québec, Québec
Canada G1V 4G2
Thiophene derivatives activity against the protozoan parasite Leishmania infantum
Journal ArticleInt J Parasitol Drugs Drug Resist, 21 , 2022.
Corrigendum: Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli
Journal ArticleMicrob Genom, 8 (10), 2022.
Nondegradable Antimicrobial Silver-Based Perovskite
Journal ArticleACS Sustain Chem Eng, 10 (15), 2022.
Simvastatin Resistance of Leishmania amazonensis Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors
Journal ArticleMicroorganisms, 10 (2), 2022.
Decreased glutamate transport in acivicin resistant Leishmania tarentolae
Journal ArticlePLoS Negl Trop Dis, 15 (12), 2021.
Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series
Journal ArticleMicroorganisms, 9 (7), 2021.
Well-Tolerated Amphotericin B Derivatives That Effectively Treat Visceral Leishmaniasis
Journal ArticleACS Infect Dis, 7 (8), 2021.
Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
Journal ArticlePLoS Negl Trop Dis, 15 (4), 2021.
Mutations in an Aquaglyceroporin as a Proven Marker of Antimony Clinical Resistance in the Parasite Leishmania donovani
Journal ArticleClin Infect Dis, 72 (10), 2021.
New insights in the mode of action of anti-leishmanial drugs by using chemical mutagenesis screens coupled to next-generation sequencing
Journal ArticleMicrob Cell, 7 (2), 2020.
Active projects
- Chaire de recherche du Canada sur la résistance aux antiantimicrobiens, from 2017-04-01 to 2024-03-31
- Drug resistance and drug targets in the protozoan parasite Leishmania, from 2019-10-01 to 2024-09-30
- Genomics of antimicrobial resistance and drug/target discovery, from 2019-07-01 to 2027-06-30
- Les bactériocines : une alternative naturelle fort prometteuse pour le remplacement des antibiotiques en production avicole., from 2019-04-01 to 2023-06-30
Recently finished projects
- Centre de recherche sur les interactions hôte-parasite (CRIHP), from 2015-04-01 to 2021-03-31
- MAchine learning for diGItal diagnosTICS of antimicrobial resistance, from 2019-10-01 to 2022-09-30