Dr. Marc Ouellette is an investigator at the Infectious Diseases and Immunity Axis of the Research Centre of the CHU de Québec-Laval University. He is also a full professor at the Department of Microbiology-Infectious Diseases and Immunology at the Laval University School of Medicine. His work focuses on antimicrobial resistance. Dr. Ouellette holds a Canada Research Chair in antimicrobial resistance and was the Scientific Director of the CIHR Institute of Infection and Immunity from 2010-2018. He is a fellow of the Royal Society of Canada and of the Canadian Academy of Health Sciences.

Dr. Ouelette’s work focuses on the protozoan parasite Leishmania and on different bacteria, including the pneumococcus. Leishmania is a neglected tropical disease that affects over 12 million people, while antibiotic resistance is a major public health issue that is receiving unprecedented political attention. His team uses several screens coupled to next-generation sequencing to find novel biomarkers of resistance in parasites and bacteria. Their screens are also used to identify new drug cellular targets against new molecules or also to define death and survival pathways that could be exploited for novel therapeutic strategies.

CHUL
2705, boulevard Laurier
R-0709
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 48184 / 42750+1 418-654-2715
marc.ouellette@crchudeque...

Latest news

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Potvin JÉ, Fani F, Queffeulou M, Gazanion É, Leprohon P, Ouellette M

Increased copy number of the target gene squalene monooxygenase as the main resistance mechanism to terbinafine in Leishmania infantum

Journal Article

Int J Parasitol Drugs Drug Resist, 23 , 2023.

Abstract | Links:

Gingras H, Peillard-Fiorente F, Godin C, Patron K, Leprohon P, Ouellette M

New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens

Journal Article

Antimicrob Agents Chemother, 67 (8), 2023.

Abstract | Links:

Bigot S, Leprohon P, Ouellette M

Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection

Journal Article

PLoS Negl Trop Dis, 17 (6), 2023.

Abstract | Links:

Bigot S, Leprohon P, Vasquez A, Bhadoria R, Skouta R, Ouellette M

Thiophene derivatives activity against the protozoan parasite Leishmania infantum

Journal Article

Int J Parasitol Drugs Drug Resist, 21 , 2023.

Abstract | Links:

Flahaut M, Leprohon P, Pham NP, Gingras H, Bourbeau J, Papadopoulou B, Maltais F, Ouellette M

Distinctive features of the oropharyngeal microbiome in Inuit of Nunavik and correlations of mild to moderate bronchial obstruction with dysbiosis

Journal Article

Sci Rep, 13 (1), 2023.

Abstract | Links:

Gingras H, Dridi B, Leprohon P, Ouellette M

Corrigendum: Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli

Journal Article

Microb Genom, 8 (10), 2022.

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Fujii TTS, Gomes PS, do Monte-Neto RL, de Oliveira Gomes DC, Ouellette M, Torres-Santos EC, Andrade-Neto VV, de Matos Guedes HL

Simvastatin Resistance of Leishmania amazonensis Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors

Journal Article

Microorganisms, 10 (2), 2022.

Abstract | Links:

Talebpour C, Fani F, Ouellette M, Salimnia H, Alamdari H

Nondegradable Antimicrobial Silver-Based Perovskite

Journal Article

ACS Sustain Chem Eng, 10 (15), 2022.

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Bhattacharya A, Leprohon P, Ouellette M

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum

Journal Article

PLoS Negl Trop Dis, 15 (4), 2021.

Abstract | Links:

Morelle C, Mukherjee A, Zhang J, Fani F, Khandelwal A, Gingras H, Trottier J, Barbier O, Leprohon P, Burke MD, Ouellette M

Well-Tolerated Amphotericin B Derivatives That Effectively Treat Visceral Leishmaniasis

Journal Article

ACS Infect Dis, 7 (8), 2021.

Abstract | Links:

219 entries « ‹ 1 of 22 › »
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Active projects

  • Caractérisation d'un traitement anti-buée en milieu médical, from 2023-05-15 to 2025-07-14
  • Chaire de recherche du Canada sur la résistance aux antiantimicrobiens, from 2017-04-01 to 2024-03-31
  • Genomics of antimicrobial resistance and drug/target discovery, from 2019-07-01 to 2027-06-30

Recently finished projects

  • Les bactériocines : une alternative naturelle fort prometteuse pour le remplacement des antibiotiques en production avicole., from 2019-04-01 to 2023-08-31
  • MAchine learning for diGItal diagnosTICS of antimicrobial resistance, from 2019-10-01 to 2022-09-30
Data provided by the Université Laval research projects registery