Dr. Lucie Germain, Ph.D., is a full professor at the Department of Surgery and Vice Dean of Research and Graduate Studies at Laval University. Within the CHU de Québec-Laval University Research Center, she was Director of the Regenerative Medicine Division until 2014. Her work, dedicated to postnatal stem cells and human tissue reconstruction, led to three clinical trials involving engineered tissues produced in vitro applied to the treatment of venous ulcers, severely burned patients and limbal stem cell deficiency of the cornea. Dr. Germain has published more than 155 peer-reviewed articles, 67 book chapters and reviews and given more than 135 invited seminars and conferences. Her sustainable contribution as health research was recognized by the Foundation scheme of Canadian Institutes of Health Research, which allowed her a financial support for seven years in 2015. The Canada research chair program also recognized Dr. Germain as a leader in the field of stem cells and regenerative medicine by granting her a junior Tier-2 chair in 2001 and a senior Tier 1 chair in 2015. In 2013, she was nominated Member of the Canadian Academy of Health Sciences and was appointed Vice-Dean of Research and Graduate Studies at the Faculty of Medicine of Laval University in 2014.

Improving patients care through the application of her research is at the heart of her motivations. She holds the Research Chair on tissue-engineered organs and translational medicine from the Foundation of Laval University. Her research is dedicated to the reconstruction of human tissues, mainly skin, cornea, blood vessels and heart valves for experimental and clinical applications. The tissue-engineered models developed by Dr. Germain are designed for physiological, pathophysiological or pharmacotoxicological studies. Her research aims to better define molecular signaling pathways involved in stem cell regulation and differentiation. Her work also focuses on improving functionality of reconstructed tissues, for example by adding melanocytes to skin substitutes to improve their pigmentation and UV protection. An important part of her research aims to shorten the time required to produce skin substitutes and to develop a serum-free culture medium for cell and tissue culture. Finally, Dr. Germain actively works on strategies aimed at integrating tissue engineering and gene therapy to find new treatments for genetic skin disorders such as epidermolysis bullosa.

1401, 18e Rue
Local: R-109, LOEX/ CMDGT
Québec, Québec
Canada G1J 1Z4
222 entries « 1 of 23 »

Cartier A, Barbier MA, Larouche D, Morissette A, Bussières A, Montalin L, Beaudoin Cloutier C, Germain L

Tie-Over Bolster Pressure Dressing Improves Outcomes of Skin Substitutes Xenografts on Athymic Mice

Journal Article

Int J Mol Sci, 23 (10), 2022.

| Links:

Desjardins P, Le-Bel G, Ghio SC, Germain L, Guérin SL

The WNK1 kinase regulates the stability of transcription factors during wound healing of human corneal epithelial cells

Journal Article

J Cell Physiol, 2022.

Abstract | Links:

Barbier MA, Piaceski AD, Larouche D, Villeneuve SH, Ghani K, Pope E, Caruso M, Germain L

Efficient Gamma-Retroviral Transduction of Primary Human Skin Cells Using the EF-c Peptide as a Transduction Enhancer

Journal Article

Curr Protoc, 2 (1), 2022.

Abstract | Links:

Roy V, Ross JP, Pépin R, Cortez Ghio S, Brodeur A, Touzel Deschênes L, Le-Bel G, Phillips DE, Milot G, Dion PA, Guérin S, Germain L, Berthod F, Auger FA, Rouleau GA, Dupré N, Gros-Louis F

Moyamoya Disease Susceptibility Gene RNF213 Regulates Endothelial Barrier Function

Journal Article

Stroke, 53 (4), 2022.

Abstract | Links:

Cortez Ghio S, Larouche D, Doucet EJ, Germain L

The role of cultured autologous bilayered skin substitutes as epithelial stem cell niches after grafting: A systematic review of clinical studies

Journal Article

Burns Open, 5 (2), 2021.

| Links:

Guérin LP, Le-Bel G, Desjardins P, Couture C, Gillard E, Boisselier É, Bazin R, Germain L, Guérin SL

The Human Tissue-Engineered Cornea (hTEC): Recent Progress

Journal Article

Int J Mol Sci, 22 (3), 2021.

Abstract | Links:

Gross C, Le-Bel G, Desjardins P, Benhassine M, Germain L, Guérin SL

Contribution of the Transcription Factors Sp1/Sp3 and AP-1 to Gene Expression during Corneal Wound Healing of Tissue-Engineered Human Corneas

Journal Article

Int J Mol Sci, 22 (22), 2021.

Abstract | Links:

Kelly C, Wallace D, Moulin V, Germain L, Zuccaro J, Galdyn I, Fish JS

Surviving an Extensive Burn Injury Using Advanced Skin Replacement Technologies

Journal Article

J Burn Care Res, 42 (6), 2021.

Abstract | Links:

Kawecki F, Mayrand D, Ayoub A, Attiogbe É, Germain L, Auger FA, Moulin VJ

Biofabrication and preclinical evaluation of a large-sized human self-assembled skin substitute

Journal Article

Biomed Mater, 16 (2), 2021.

Abstract | Links:

Kakumani PK, Guitart T, Houle F, Harvey LM, Goyer B, Germain L, Gebauer F, Simard MJ

CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma

Journal Article

Oncogene, 40 (18), 2021.

Abstract | Links:

222 entries « 1 of 23 »
Signaler des ajouts ou des modifications

Active projects

  • Chaire de recherche du Canada en Cellules Souches et Génie Tissulaire, from 2022-01-01 to 2028-12-31
  • Chaire de recherche sur les organes reconstruits en laboratoire et leurs applications cliniques, from 2013-05-01 to 2023-08-12
  • Combining tissue-engineered skin with ex vivo gene therapy correction to develop a treatment for epidermolysis bullosa, from 2022-04-01 to 2024-03-31
  • Cultured epithelial corneal autografts for the treatment of canadians with limbal stem cell deficiency, from 2020-01-01 to 2023-01-31
  • Les cellules souches épithéliales et le génie tissulaire : de la recherche fondamentale à la recherche clinique., from 2015-07-01 to 2022-06-30
  • Recherche en vue de développer un traitement pour les patients atteints d'épidermolyse bulleuse dystrophique, from 2021-09-14 to 2023-09-13
  • Self-Assembly Skin Substitutes (SASS) for the treatment of acute wounds of Canadian burn patients, from 2020-01-01 to 2023-01-31
  • Soutien à la recherche dans le domaine des maladies auto-immunes et de la cicatrisation, from 2016-04-01 to 2027-03-31
  • Tissue-engineered solutions for uro-genital reconstruction, and replacing banned synthetic meshes, from 2021-10-01 to 2026-09-30
  • Towards an epidermolysis bullosa clinical trial with tissue-engineered skin after ex vivo gene therapy correction, from 2020-08-01 to 2023-01-31

Recently finished projects

  • Chaire de recherche du Canada EN CELLULES SOUCHES ET GÉNIE TISSULAIRE, from 2015-01-01 to 2021-12-31
  • Évaluation de la qualité, de la structure et des propriétés fonctionnelles des peaux reconstruites par génie tissulaire, from 2019-09-01 to 2021-08-31
  • Monitoring expression of the transcription factors Sp1 and NFI as markers of cell quality in human corneal epithelial cells cultured on different cell carriers, from 2021-02-01 to 2022-03-31
  • The Canadian National Transplant Research Program : Increasing Donation and Improving Transplantation Outcomes, from 2013-04-01 to 2022-03-31
  • Tissue-engineered solutions for uro-genital reconstruction, and replacing banned synthetic meshes, from 2021-03-01 to 2022-02-28
Data provided by the Université Laval research projects registery