Dr. Michou completed her medical studies at l’Université d’Angers, her Rheumatology residency at l’Université Denis-Diderot-Paris VII and her PhD in Human Genetics at l’Université René-Descartes-Paris V (France). She had in parallel completed a two-year clinical fellowship in fragility bone diseases at the centre Viggo Petersen, Rheumatology department, Lariboisière hospital, Assistance publique-Hôpitaux de Paris, France.

Dr Michou is a clinical investigator at the Centre de Recherche du CHU de Québec-Laval University, rheumatologist at the CHUL, and associate professor at Laval University’s School of Medicine, Quebec. Dr Michou is the principal investigator of several academic research projects in the field of rheumatic diseases, mainly funded by the Fonds de recherche du Québec-Santé, Canadian Institutes of Health research, the Arthritis Society, and the CHU de Québec foundation. She supervises master and PhD students, as well as the clinical research projects of rheumatology and internal medicine residents.

She is the author or coauthor of 53 scientific refereed articles, over  100 oral or poster communications in scientific congresses, and approximately 30 articles of continuing medical education for rheumatologists or family doctors.

Dr. Michou’s research interests are human genetics of bone and joint diseases, particularly Paget’s disease of the bone, rare bone diseases, osteoporosis, Dupuytren’s disease and rheumatoid arthritis. She is the manager of the Biobank and Bank of Data for the Study of Heritable Musculoskeletal Diseases and co-manager of the Biobank and Repository Data for Systemic Autoimmune Rheumatic Diseases.

CHUL
2705, boulevard Laurier
T0-83
Québec, Québec
Canada G1V 4G2

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73 entries « 1 of 8 »

Michou L, Gamache P, Guertin JR, Tarride JE, Brown JP, Jean S

Prevalence and incidence of Paget's disease of bone: Temporal trend over 20 years in the province of Quebec, Canada

Journal Article

Bone, 176 , 2023.

Abstract | Links:

You Y, Simonyan D, Bureau A, Gagnon E, Albert C, Guertin JR, Tarride JE, Brown JP, Michou L

Molecular test of Paget's disease of bone in families not linked to SQSTM1 gene mutations

Journal Article

Bone Rep, 18 , 2023.

Abstract | Links:

Gendron E, Bouchard F, Singbo N, Brown JP, Michou L

Decline in clinical severity of Paget's disease of bone: Comparison between a contemporary cohort and a historical cohort

Journal Article

Bone, 170 , 2023.

Abstract | Links:

Colmegna I, Valerio V, Amiable N, Useche M, Rampakakis E, Flamand L, Rollet-Labelle E, Bessette L, Fitzcharles MA, Hazel E, McCormack D, Michou L, Panopalis P, Langlois MA, Bernatsky S, Fortin PR

COVID-19 Vaccine in Immunosuppressed Adults with Autoimmune rheumatic Diseases (COVIAAD): safety, immunogenicity and antibody persistence at 12 months following Moderna Spikevax primary series

Journal Article

RMD Open, 9 (4), 2023.

Abstract | Links:

Michou L, Julien AS, Witteman HO, Légaré J, Ratelle L, Godbout A, Tardif J, Côté S, Boily G, Lui R, Ikic A, Trudeau J, Tremblay JL, Fortin I, Bessette L, Chetaille AL, Fortin PR

Measuring the impact of an educational intervention in rheumatoid arthritis: An open-label, randomized trial

Journal Article

Arch Rheumatol, 37 (2), 2022.

Abstract | Links:

Dessay M, Couture E, Maaroufi H, Fournier F, Gagnon E, Droit A, Brown JP, Michou L

Attenuated clinical and osteoclastic phenotypes of Paget's disease of bone linked to the p.Pro392Leu/SQSTM1 mutation by a rare variant in the DOCK6 gene

Journal Article

BMC Med Genomics, 15 (1), 2022.

Abstract | Links:

Coll JC, Garceau É, Leslie WD, Genest M, Michou L, Weisnagel SJ, Mac-Way F, Albert C, Morin SN, Rabasa-Lhoret R, Gagnon C

Prevalence of Vertebral Fractures in Adults With Type 1 Diabetes: DenSiFy Study (Diabetes Spine Fractures)

Journal Article

J Clin Endocrinol Metab, 107 (5), 2022.

Abstract | Links:

Farlay D, Rizzo S, Ste-Marie LG, Michou L, Morin SN, Qiu S, Chavassieux P, Chapurlat RD, Rao SD, Brown JP, Boivin G

Duration-Dependent Increase of Human Bone Matrix Mineralization in Long-Term Bisphosphonate Users with Atypical Femur Fracture

Journal Article

J Bone Miner Res, 36 (6), 2021.

Abstract | Links:

Vaillancourt M, Desaulniers P, Paré G, Pagé N, Lachhab A, Kerever A, Julien AS, Amiable N, Pelletier M, Tessier PA, Bessette L, Michou L, Fortin PR, Fernandes MJ

Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis

Journal Article

Sci Rep, 11 (1), 2021.

Abstract | Links:

Ruel-Gagné S, Simonyan D, Légaré J, Bessette L, Fortin PR, Lacaille D, Dogba MJ, Michou L

Expectations and educational needs of rheumatologists, rheumatology fellows and patients in the field of precision medicine in Canada, a quantitative cross-sectional and descriptive study

Journal Article

BMC Rheumatol, 5 (1), 2021.

Abstract | Links:

73 entries « 1 of 8 »
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Active projects

  • Étude des évènements cardiovasculaires et des calcifications vasculaires dans la maladie osseuse de Paget, from 2024-01-31 to 2025-02-28
  • Facteurs de risque associés à la résistance à de multiples agents biologiques dans la polyarthrite rhumatoïde et l'arthrite psoriasique périphérique, from 2020-05-14 to 2024-03-31
  • Impact de la capillaroscopie sur la prise en charge des connectivites indifférenciées : une étude clinique pilote randomisée, from 2015-08-24 to 2024-03-31
  • Multifaceted Intervention using Telehealth to Reduce the risk of Falls and Fractures in Older Men (MisterFit study): a Pilot Study , from 2021-10-01 to 2025-09-30
  • Transgenic rats overexpressing HDAC9 to explore the missing link between osteoporosis and vascular disease in chronic kidney disease, from 2023-06-21 to 2024-03-31

Recently finished projects

  • Clinical validity and clinical utility of a screening test for Paget's disease of bone, from 2019-03-01 to 2023-03-31
  • Impact fonctionnel d’un variant rare du gène WNT1 en présence de bisphosphonates in vitro dans les trois principaux types de cellules osseuses, from 2021-09-08 to 2022-03-31
  • Rôle de SUPT20H dans la pathogénie de la polyarthrite rhumatoïde, from 2022-03-10 to 2023-02-28
Data provided by the Université Laval research projects registery