Dr. St-Amand completed his doctoral studies at Laval University, and his postdoctoral studies at the University of British Columbia. In 1998, he optimized the SAGE method in his laboratory located in Japan, at the pharmaceutical company Otsuka. He is currently a full professor in the Department of Molecular Medicine at Laval University, and director of the Functional Genomics Laboratory and SAGE platform at the CHU Research Centre of Quebec. He is an expert in genetic engineering and functional genomics.

Dr. St-Amand’s research program aims to characterize the transcriptomes of several tissues and their regulation through physical exercise, a lipid-rich diet, and steroid hormones, in order to identify, clone and characterize functionally the genes of interest that can be used as therapeutic targets for coronary heart disease, obesity, and cancer. Dr. St-Amand’s laboratory is developing genetic engineering methods and bioinformatics programs, particularly for the analysis of functional genomics results. Dr. St-Amand developed the first SAGE platform in Canada. This powerful strategy makes it possible to compare all transcripts, including new genes, to identify the molecular mechanisms responsible for diseases.

Dr. St-Amand and his team are also studying in vitro cells and knockout mice to characterize the functions of candidate genes. These research projects will identify therapeutic targets to, in turn, develop therapeutic treatments for obesity and cardiovascular disease.

CHUL
2705, boulevard Laurier
R-4775
Québec, Québec
Canada G1V 4G2
82 entries « 1 of 9 »

Ghanemi A, Yoshioka M, St-Amand J

Secreted Protein Acidic and Rich in Cysteine (SPARC)-Mediated Exercise Effects: Illustrative Molecular Pathways against Various Diseases

Journal Article

Diseases, 11 (1), 2023.

Abstract | Links:

Ghanemi A, Yoshioka M, St-Amand J

Secreted Protein Acidic and Rich in Cysteine (SPARC) to Manage Coronavirus Disease-2019 (COVID-19) Pandemic and the Post-COVID-19 Health Crisis

Journal Article

Medicines (Basel), 10 (5), 2023.

Abstract | Links:

Ghanemi A, Yoshioka M, St-Amand J

Exercise, Diet and Sleeping as Regenerative Medicine Adjuvants: Obesity and Ageing as Illustrations

Journal Article

Medicines (Basel), 9 (1), 2022.

Abstract | Links:

Ghanemi A, Melouane A, Yoshioka M, St-Amand J

Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Leads to an Accelerated Ageing Phenotype Which Is Improved by Exercise Whereas SPARC Overexpression Mimics Exercise Effects in Mice

Journal Article

Metabolites, 12 (2), 2022.

Abstract | Links:

Ghanemi A, Yoshioka M, St-Amand J

Secreted Protein Acidic and Rich in Cysteine as an Exercise-Induced Gene: Towards Novel Molecular Therapies for Immobilization-Related Muscle Atrophy in Elderly Patients

Journal Article

Genes (Basel), 13 (6), 2022.

Abstract | Links:

Ghanemi A, Yoshioka M, St-Amand J

Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential "Exercise Substitute" Antiageing Therapy

Journal Article

Genes (Basel), 13 (6), 2022.

Abstract | Links:

Ghanemi A, Yoshioka M, St-Amand J

Tricking the Brain with Leptin to Limit Post Liposuction and Post Bariatric Surgery Weight Regain?

Journal Article

Diseases, 10 (4), 2022.

Abstract | Links:

Ghanemi A, Yoshioka M, St-Amand J

DNA Damage as a Mechanistic Link between Air Pollution and Obesity

Journal Article

Medicines (Basel), 10 (1), 2022.

Abstract | Links:

Ghanemi A, Yoshioka M, St-Amand J

In Vitro Mimicking of Obesity-Induced Biochemical Environment to Study Obesity Impacts on Cells and Tissues

Journal Article

Diseases, 10 (4), 2022.

Abstract | Links:

Ghanemi A, Yoshioka M, St-Amand J

Mapping Genetics and Epigenetics to Explore the Pathways beyond the Correlated Ageing Phenotype

Journal Article

Genes (Basel), 13 (11), 2022.

Abstract | Links:

82 entries « 1 of 9 »
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Active projects

  • Roles of SPARC against muscle atrophy, sarcopenia and age-related metabolic disorders, from 2023-03-01 to 2024-02-29
Data provided by the Université Laval research projects registery