Dr. St-Amand completed his doctoral studies at Laval University, and his postdoctoral studies at the University of British Columbia. In 1998, he optimized the SAGE method in his laboratory located in Japan, at the pharmaceutical company Otsuka. He is currently a full professor in the Department of Molecular Medicine at Laval University, and director of the Functional Genomics Laboratory and SAGE platform at the CHU Research Centre of Quebec. He is an expert in genetic engineering and functional genomics.
Dr. St-Amand’s research program aims to characterize the transcriptomes of several tissues and their regulation through physical exercise, a lipid-rich diet, and steroid hormones, in order to identify, clone and characterize functionally the genes of interest that can be used as therapeutic targets for coronary heart disease, obesity, and cancer. Dr. St-Amand’s laboratory is developing genetic engineering methods and bioinformatics programs, particularly for the analysis of functional genomics results. Dr. St-Amand developed the first SAGE platform in Canada. This powerful strategy makes it possible to compare all transcripts, including new genes, to identify the molecular mechanisms responsible for diseases.
Dr. St-Amand and his team are also studying in vitro cells and knockout mice to characterize the functions of candidate genes. These research projects will identify therapeutic targets to, in turn, develop therapeutic treatments for obesity and cardiovascular disease.
2705, boulevard Laurier
R-4775
Québec, Québec
Canada G1V 4G2
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- Yoshioka, MayumiEmployeeCHUL+1 418-525-4444, extension 46051+1 418-654-2298mayumi.yoshioka@crchudequebec.ulaval.ca
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
DNA Damage as a Mechanistic Link between Air Pollution and Obesity
Journal ArticleMedicines (Basel), 10 (1), 2022.
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Mapping Genetics and Epigenetics to Explore the Pathways beyond the Correlated Ageing Phenotype
Journal ArticleGenes (Basel), 13 (11), 2022.
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In Vitro Mimicking of Obesity-Induced Biochemical Environment to Study Obesity Impacts on Cells and Tissues
Journal ArticleDiseases, 10 (4), 2022.
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Tricking the Brain with Leptin to Limit Post Liposuction and Post Bariatric Surgery Weight Regain?
Journal ArticleDiseases, 10 (4), 2022.
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Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential "Exercise Substitute" Antiageing Therapy
Journal ArticleGenes (Basel), 13 (6), 2022.
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Secreted Protein Acidic and Rich in Cysteine as an Exercise-Induced Gene: Towards Novel Molecular Therapies for Immobilization-Related Muscle Atrophy in Elderly Patients
Journal ArticleGenes (Basel), 13 (6), 2022.
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Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Leads to an Accelerated Ageing Phenotype Which Is Improved by Exercise Whereas SPARC Overexpression Mimics Exercise Effects in Mice
Journal ArticleMetabolites, 12 (2), 2022.
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Exercise, Diet and Sleeping as Regenerative Medicine Adjuvants: Obesity and Ageing as Illustrations
Journal ArticleMedicines (Basel), 9 (1), 2022.
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Diet Impact on Obesity beyond Calories and Trefoil Factor Family 2 (TFF2) as an Illustration: Metabolic Implications and Potential Applications
Journal ArticleBiomolecules, 11 (12), 2021.
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Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics
Journal ArticleDiseases, 9 (4), 2021.
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Recently finished projects
- Roles of exercise-induced gene, SPARC, against sarcopenia: Link between extracellular matrix and mitochondria., from 2014-04-01 to 2021-03-31