Dr. St-Amand completed his doctoral studies at Laval University, and his postdoctoral studies at the University of British Columbia. In 1998, he optimized the SAGE method in his laboratory located in Japan, at the pharmaceutical company Otsuka. He is currently a full professor in the Department of Molecular Medicine at Laval University, and director of the Functional Genomics Laboratory and SAGE platform at the CHU Research Centre of Quebec. He is an expert in genetic engineering and functional genomics.
Dr. St-Amand’s research program aims to characterize the transcriptomes of several tissues and their regulation through physical exercise, a lipid-rich diet, and steroid hormones, in order to identify, clone and characterize functionally the genes of interest that can be used as therapeutic targets for coronary heart disease, obesity, and cancer. Dr. St-Amand’s laboratory is developing genetic engineering methods and bioinformatics programs, particularly for the analysis of functional genomics results. Dr. St-Amand developed the first SAGE platform in Canada. This powerful strategy makes it possible to compare all transcripts, including new genes, to identify the molecular mechanisms responsible for diseases.
Dr. St-Amand and his team are also studying in vitro cells and knockout mice to characterize the functions of candidate genes. These research projects will identify therapeutic targets to, in turn, develop therapeutic treatments for obesity and cardiovascular disease.
2705, boulevard Laurier
R-4775
Québec, Québec
Canada G1V 4G2
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- Ghanemi, AbdelazizDoctoral studentCHUL+1 418-525-4444, extension 42296Abdelaziz.Ghanemi@crchudequebec.ulaval.ca
2705, boul. Laurier
R-4720
Québec, Québec
Canada G1V 4G2 - Yoshioka, MayumiEmployeeCHUL+1 418-525-4444, extension 46051+1 418-654-2298mayumi.yoshioka@crchudequebec.ulaval.ca
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential "Exercise Substitute" Antiageing Therapy
Journal ArticleGenes (Basel), 13 (6), 2022.
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Secreted Protein Acidic and Rich in Cysteine as an Exercise-Induced Gene: Towards Novel Molecular Therapies for Immobilization-Related Muscle Atrophy in Elderly Patients
Journal ArticleGenes (Basel), 13 (6), 2022.
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Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Leads to an Accelerated Ageing Phenotype Which Is Improved by Exercise Whereas SPARC Overexpression Mimics Exercise Effects in Mice
Journal ArticleMetabolites, 12 (2), 2022.
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Exercise, Diet and Sleeping as Regenerative Medicine Adjuvants: Obesity and Ageing as Illustrations
Journal ArticleMedicines (Basel), 9 (1), 2022.
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Diet Impact on Obesity beyond Calories and Trefoil Factor Family 2 (TFF2) as an Illustration: Metabolic Implications and Potential Applications
Journal ArticleBiomolecules, 11 (12), 2021.
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Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics
Journal ArticleDiseases, 9 (4), 2021.
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Secreted Protein Acidic and Rich in Cysteine as a Molecular Physiological and Pathological Biomarker
Journal ArticleBiomolecules, 11 (11), 2021.
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Measuring Exercise-Induced Secreted Protein Acidic and Rich in Cysteine Expression as a Molecular Tool to Optimize Personalized Medicine
Journal ArticleGenes (Basel), 12 (11), 2021.
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Post-Coronavirus Disease-2019 (COVID-19): Toward a Severe Multi-Level Health Crisis?
Journal ArticleMed Sci (Basel), 9 (4), 2021.
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Impact of Adiposity and Fat Distribution, Rather Than Obesity, on Antibodies as an Illustration of Weight-Loss-Independent Exercise Benefits
Journal ArticleMedicines (Basel), 8 (10), 2021.
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Recently finished projects
- Roles of exercise-induced gene, SPARC, against sarcopenia: Link between extracellular matrix and mitochondria., from 2014-04-01 to 2021-03-31