Dr. Jessica Deslauriers is a researcher within the Neurosciences Axis of the CRCHU de Québec-Université Laval, and an Assistant Professor at the Faculty of Pharmacy, Université Laval.

Dr. Deslauriers completed her graduate studies in physiology at Université de Sherbrookeunder the supervision of Drs. Sylvain Grignon and Philippe Sarret. She investigated the role of prenatal inflammation in the development of psychotic-like and depressive-like behaviors in mice. She then pursued a postdoctoral fellowship at the University of California San Diego and Veterans Affairs San Diego Medical Center under the supervision of Dr. Victoria Risbrough. The preclinical and clinical studies conducted by Dr. Deslauriers helped to gain a better understanding of the role of the inflammatory response following a psychological trauma in the development of posttraumatic stress disorder (PTSD). She acquired a strong expertise in pharmacology, molecular biology, neurodevelopmental models of psychiatric disorders, behavioral neuroscience and study of the immune signaling pathways.

Susceptibility to post-traumatic disorders: towards a personalized medicine in psychiatry

90% of the population has endorsed or will experience a traumatic event during their life, and more than half of these individuals develop psychiatric symptoms, such as PTSD, schizophrenia, or depression. The current available treatments have a limited efficacy. Thus, there is an urgent need to develop novel pharmacological therapies.

Dr. Deslauriers’ laboratory at the CRCHU de Québec-Université Laval uses translational and multidisciplinary approaches (1) to understand the mechanisms of susceptibility to psychological trauma, with a primary focus on immune signaling pathways; (2) to identify inflammatory and imaging biomarkers of increased susceptibility to trauma; and (3) to use a personalized medicine by targeting pharmacological approaches based on molecular and pathophysiological characteristics specific to the patient or the “at-risk” individual. Dr. Deslauriers uses a methodology translatable from rodents to humans, including behavioral paradigms, magnetic resonance imaging, as well as genetic and chemogenetic approaches. Her projects are currently funded by the National Institute of Mental Health (NIMH) and the Fondation du CHU de Québec.

CHUL
2705 boul Laurier
R-3706
Québec, Qc
Canada G1V 4G2

Latest news

Data not available

20 entries « 2 of 2 »

Chevin M, Guiraut C, Maurice-Gelinas C, Deslauriers J, Grignon S, Sébire G

Neuroprotective effects of hypothermia in inflammatory-sensitized hypoxic-ischemic encephalopathy

Journal Article

Int J Dev Neurosci, 55 , 2016.

Abstract | Links:

Toth M, Flandreau EI, Deslauriers J, Geyer MA, Mansuy IM, Merlo Pich E, Risbrough VB

Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood

Journal Article

Neuropsychopharmacology, 41 (6), 2016.

Abstract | Links:

Monpays C, Deslauriers J, Sarret P, Grignon S

Mitochondrial Dysfunction in Schizophrenia: Determination of Mitochondrial Respiratory Activity in a Two-Hit Mouse Model

Journal Article

J Mol Neurosci, 59 (4), 2016.

Abstract | Links:

Deslauriers J, Belleville K, Beaudet N, Sarret P, Grignon S

A two-hit model of suicide-trait-related behaviors in the context of a schizophrenia-like phenotype: Distinct effects of lithium chloride and clozapine

Journal Article

Physiol Behav, 156 , 2016.

Abstract | Links:

Deslauriers J, Racine W, Sarret P, Grignon S

Preventive effect of α-lipoic acid on prepulse inhibition deficits in a juvenile two-hit model of schizophrenia

Journal Article

Neuroscience, 272 , 2014.

Abstract | Links:

Deslauriers J, Desmarais C, Sarret P, Grignon S

Implication of the ERK/MAPK pathway in antipsychotics-induced dopamine D2 receptor upregulation and in the preventive effects of (±)-α-lipoic acid in SH-SY5Y neuroblastoma cells

Journal Article

J Mol Neurosci, 52 (3), 2014.

Abstract | Links:

Deslauriers J, Desmarais C, Sarret P, Grignon S

α-Lipoic acid interaction with dopamine D2 receptor-dependent activation of the Akt/GSK-3β signaling pathway induced by antipsychotics: potential relevance for the treatment of schizophrenia

Journal Article

J Mol Neurosci, 50 (1), 2013.

Abstract | Links:

Deslauriers J, Larouche A, Sarret P, Grignon S

Combination of prenatal immune challenge and restraint stress affects prepulse inhibition and dopaminergic/GABAergic markers

Journal Article

Prog Neuropsychopharmacol Biol Psychiatry, 45 , 2013.

Abstract | Links:

Bergeron JD, Deslauriers J, Grignon S, Fortier LC, Lepage M, Stroh T, Poyart C, Sebire G

White matter injury and autistic-like behavior predominantly affecting male rat offspring exposed to group B streptococcal maternal inflammation

Journal Article

Dev Neurosci, 35 (6), 2013.

Abstract | Links:

Deslauriers J, Lefrancois M, Larouche A, Sarret P, Grignon S

Antipsychotic-induced DRD2 upregulation and its prevention by α-lipoic acid in SH-SY5Y neuroblastoma cells

Journal Article

Synapse, 65 (4), 2011.

Abstract | Links:

20 entries « 2 of 2 »
Signaler des ajouts ou des modifications

Active projects

  • Laboratoire de biomarqueurs pour la recherche sur le trouble de stress post-traumatique, from 2021-07-09 to 2024-06-30
  • Mécanismes de vulnérabilité au trauma psychologique: mieux comprendre le rôle de l'inflammation et de la barrière hémato-encéphalique pour cibler une pharmacothérapie de précision, from 2021-07-01 to 2025-06-30
  • Mécanismes de vulnérabilité au trauma psychologique: mieux comprendre le rôle de l’inflammation et de la barrière hémato-encéphalique pour cibler une pharmacothérapie de précision, from 2021-07-01 to 2025-06-30
  • PAT-MOBILE (Psychosis And Trauma – Measurements of BIomarkers Levels in Exosomes) : étude multidimensionnelle des facteurs déterminants et exosomes comme indicateurs de pronostic et traitement, from 2023-06-01 to 2026-05-31
  • Sex-and region-dependent blood-brain barrier integrity: demystifying the interwined crosstalk between neurovascular functions and coping behaviors, from 2024-04-01 to 2029-03-31
  • Sex-and-region-dependent blood-brain barrier integrity: demystifying the intertwined crosstalk between neurovascular functions and coping behaviors, from 2024-04-01 to 2025-03-31
  • Vieillissement et troubles neurocognitifs: identification de biomarqueurs cérébraux et stresseurs psychosociaux au travail, from 2024-01-01 to 2026-12-31

Recently finished projects

  • A putative role for adaptive immunity in PTSD symptomatology, from 2022-09-30 to 2023-09-30
  • Démarrage d'un nouveau professeur, from 2020-01-01 to 2023-12-31
  • FGR-Brain's adaptation to stress and stress memory: bridging a gap between inflammation and blood-brain barrier integrity, from 2022-09-01 to 2023-08-31
  • Fonds de démarrage. Jessica Deslauriers, from 2020-01-06 to 2024-03-31
  • Peripheral and central mechanisms of trauma: angiotensin and BBB integrity, from 2020-01-01 to 2022-12-16
  • Posttraumatic disorders and brain-derived exosomes: towards targeting exosomal-based therapy to promote resilience, from 2023-02-02 to 2023-12-31
  • Projet PAT-MOBILE (Psychosis And Trauma - Measurements of Biomarkers Levels in exosomes) : étude pilote axée sur les exosomes comme indicateurs de diagnostic, pronostic et traitement, from 2022-04-01 to 2023-03-31
  • Projet portant sur l'étude des biomarqueurs inflammatoires et neurovasculaires dans le trouble de stress post-traumatique, from 2022-07-03 to 2024-03-31
  • Troubles psychotiques, trauma et inflammation cérébrale: les exosomes comme fenêtre sur une maladie du cerveau, from 2022-01-01 to 2023-12-31
Data provided by the Université Laval research projects registery