Professor Jérôme Frenette is a researcher with a background in physical therapy and post-graduate training in muscle physiology and immunology at the University of California in Los-Angeles. He is a full-time researcher at the Centre de recherche du CHU de Québec-Laval University, and full professor in the department of rehabilitation at Laval University’s School of Medicine. He has been the principal investigator on several CIHR and NSERC grants. Many of his publications, and one CIHR grant were recognized and rewarded as being among the best in the field of muscle physiology. He started his career as a researcher by investigating the roles played by blood cells and mechanical loading in models of tendon injury and muscle atrophy/regrowth. In 2005, he expanded his research program to include the Buruli Ulcer, which is caused by mycobacterium ulcerans, a neglected disease of wet tropical zones, that is closely related to tuberculosis and leprosy. His research group was the first to show that mycobacterium ulcerans and its toxin, mycolactone, extend well beyond the skin, and severely affect underlying skeletal muscles. Today, the focus of his research program is to understand the link between osteoporosis and muscle atrophy/disease through one common pathway i.e. the RANK/RANKL/OPG pathway. In collaboration with Duchenne muscular dystrophy foundations in Canada, the United States and Australia, as well as sustainable financial support from public and private sources, his team is developing new drugs that would potentially alleviate, in tandem, osteoporosis and muscle degeneration in Duchenne muscular dystrophy patients or other forms of bone and muscle diseases.

CHUL
2705, boulevard Laurier
P-09800
Québec, Québec
Canada G1V 4G2
69 entries « 7 of 7 »

Frenette J, Côté CH

Modulation of structural protein content of the myotendinous junction following eccentric contractions

Journal Article

Int J Sports Med, 21 (5), 2000.

Abstract | Links:

Frenette J, Cai B, Tidball JG

Complement activation promotes muscle inflammation during modified muscle use

Journal Article

Am J Pathol, 156 (6), 2000.

Abstract | Links:

Tidball JG, Berchenko E, Frenette J

Macrophage invasion does not contribute to muscle membrane injury during inflammation

Journal Article

J Leukoc Biol, 65 (4), 1999.

Abstract | Links:

Piedboeuf B, Gamache M, Frenette J, Horowitz S, Baldwin HS, Petrov P

Increased endothelial cell expression of platelet-endothelial cell adhesion molecule-1 during hyperoxic lung injury

Journal Article

Am J Respir Cell Mol Biol, 19 (4), 1998.

Abstract | Links:

Frenette J, Tidball JG

Mechanical loading regulates expression of talin and its mRNA, which are concentrated at myotendinous junctions

Journal Article

Am J Physiol, 275 (3), 1998.

Abstract | Links:

Côté CH, Perreault G, Frenette J

Carbohydrate utilization in rat soleus muscle is influenced by carbonic anhydrase III activity

Journal Article

Am J Physiol, 273 (4), 1997.

Abstract | Links:

Piedboeuf B, Frenette J, Petrov P, Welty SE, Kazzaz JA, Horowitz S

In vivo expression of intercellular adhesion molecule 1 in type II pneumocytes during hyperoxia

Journal Article

Am J Respir Cell Mol Biol, 15 (1), 1996.

Abstract | Links:

Côté C, Riverin H, Barras MJ, Tremblay RR, Frémont P, Frenette J

Effect of carbonic anhydrase III inhibition on substrate utilization and fatigue in rat soleus

Journal Article

Can J Physiol Pharmacol, 71 (3-4), 1993.

Abstract | Links:

Frémont P, Riverin H, Frenette J, Rogers PA, Côté C

Fatigue and recovery of rat soleus muscle are influenced by inhibition of an intracellular carbonic anhydrase isoform

Journal Article

Am J Physiol, 260 (3 Pt 2), 1991.

Abstract | Links:

69 entries « 7 of 7 »
Signaler des ajouts ou des modifications

Active projects

  • Development of a monosaccharide therapy using N-acetylglucosamine to mitigate Duchenne muscular dystrophy, from 2021-05-31 to 2024-05-30
  • Investigation of the role of galectin-3 and its ligands in skeletal muscle strength, regeneration, and pathology, from 2018-10-01 to 2023-03-31
  • Multifunctional properties of osteoprotegerin in muscular dystrophy and muscle repair, from 2020-04-01 to 2025-03-31

Recently finished projects

  • Deciphering the role of RANK/RANKL/OPG in skeletal muscle., from 2016-04-01 to 2022-03-31
  • Development of a glycobiology therapy to mitigate the progression of Duchenne muscular dystrophy, from 2021-07-01 to 2022-06-30
  • Development of a therapy for Duchenne muscular dystrophy using N-acetylglucosamine, from 2019-06-15 to 2021-03-31
  • Does anti-RANKL therapy prevent glucocorticoid induced bone loss and promote muscle function in a mouse model of Duchenne muscular dystrophy, from 2021-04-01 to 2022-03-31
  • Does anti-RANKL therapy prevent glucocorticoid induced bone loss in a mouse model of Duchenne muscular dystrophy?, from 2020-10-01 to 2021-07-31
  • La protéine S100B est-elle un outil de dépistage valide pour réduire le nombre de tomodensitométries inutiles suite à un traumatisme cranio-cérébral léger?, from 2017-04-01 to 2022-01-31
  • Therapeutic impact of OPG on muscle structure and function in a preclinical mouse model of Duchenne Muscular Distrophy, from 2016-02-17 to 2021-02-16
  • To understand mechanistically how RANK/RANKL/OPG and b-adrenergic pathways mitigate Duchenne muscular dystrophy, from 2016-07-01 to 2020-06-30
Data provided by the Université Laval research projects registery