Professor Jérôme Frenette is a researcher with a background in physical therapy and post-graduate training in muscle physiology and immunology at the University of California in Los-Angeles. He is a full-time researcher at the Centre de recherche du CHU de Québec-Laval University, and full professor in the department of rehabilitation at Laval University’s School of Medicine. He has been the principal investigator on several CIHR and NSERC grants. Many of his publications, and one CIHR grant were recognized and rewarded as being among the best in the field of muscle physiology. He started his career as a researcher by investigating the roles played by blood cells and mechanical loading in models of tendon injury and muscle atrophy/regrowth. In 2005, he expanded his research program to include the Buruli Ulcer, which is caused by mycobacterium ulcerans, a neglected disease of wet tropical zones, that is closely related to tuberculosis and leprosy. His research group was the first to show that mycobacterium ulcerans and its toxin, mycolactone, extend well beyond the skin, and severely affect underlying skeletal muscles. Today, the focus of his research program is to understand the link between osteoporosis and muscle atrophy/disease through one common pathway i.e. the RANK/RANKL/OPG pathway. In collaboration with Duchenne muscular dystrophy foundations in Canada, the United States and Australia, as well as sustainable financial support from public and private sources, his team is developing new drugs that would potentially alleviate, in tandem, osteoporosis and muscle degeneration in Duchenne muscular dystrophy patients or other forms of bone and muscle diseases.

CHUL
2705, boulevard Laurier
P-09800
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 47779 / 47954+1 418-654-2145
jerome.frenette@crchudequ...

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Bentzinger CF, von Maltzahn J, Dumont NA, Stark DA, Wang YX, Nhan K, Frenette J, Cornelison D, Rudnicki MA

Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength

Journal Article

J Cell Biol, 205 (1), 2014.

Abstract | Links:

Aubrey J, Esfandiari N, Baracos V, Buteau F, Frenette J, Putman C, Mazurak V

Measurement of skeletal muscle radiation attenuation and basis of its biological variation

Journal Article

Acta Physiol (Oxf), 210 (3), 2014.

Abstract | Links:

de la Durantaye M, Piette AB, van Rooijen N, Frenette J

Macrophage depletion reduces cell proliferation and extracellular matrix accumulation but increases the ultimate tensile strength of injured Achilles tendons

Journal Article

J Orthop Res, 32 (2), 2014.

Abstract | Links:

Dumont NA, Frenette J

Macrophage colony-stimulating factor-induced macrophage differentiation promotes regrowth in atrophied skeletal muscles and C2C12 myotubes

Journal Article

Am J Pathol, 182 (2), 2013.

Abstract | Links:

Dufresne S, Frenette J

Investigation of wild-type and mycolactone-negative mutant Mycobacterium ulcerans on skeletal muscle: IGF-1 protects against mycolactone-induced muscle catabolism

Journal Article

Am J Physiol Regul Integr Comp Physiol, 304 (9), 2013.

Abstract | Links:

Houngbedji GM, Bouchard P, Frenette J

Mycobacterium ulcerans infections cause progressive muscle atrophy and dysfunction, and mycolactone impairs satellite cell proliferation

Journal Article

Am J Physiol Regul Integr Comp Physiol, 300 (3), 2011.

Abstract | Links:

Houngbedji GM, Frenette J

[Buruli ulcer - beyond the skin, impact on skeletal muscle]

Journal Article

Med Sci (Paris), 27 (2), 2011.

Abstract | Links:

Dumont N, Frenette J

Macrophages protect against muscle atrophy and promote muscle recovery in vivo and in vitro: a mechanism partly dependent on the insulin-like growth factor-1 signaling molecule

Journal Article

Am J Pathol, 176 (5), 2010.

Abstract | Links:

Godbout C, Bilodeau R, Van Rooijen N, Bouchard P, Frenette J

Transient neutropenia increases macrophage accumulation and cell proliferation but does not improve repair following intratendinous rupture of Achilles tendon

Journal Article

J Orthop Res, 28 (8), 2010.

Abstract | Links:

Goudenege S, Lamarre Y, Dumont N, Rousseau J, Frenette J, Skuk D, Tremblay JP

Laminin-111: a potential therapeutic agent for Duchenne muscular dystrophy

Journal Article

Mol Ther, 18 (12), 2010.

Abstract | Links:

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Active projects

  • Decipher the physiological functions of osteoprotegerin in skeletal and cardiac muscles, from 2023-04-01 to 2028-03-31
  • Multifunctional properties of osteoprotegerin in muscular dystrophy and muscle repair, from 2020-04-01 to 2025-03-31

Recently finished projects

  • Development of a glycobiology therapy to mitigate the progression of Duchenne muscular dystrophy, from 2021-07-01 to 2023-02-28
  • Development of a monosaccharide therapy using N-acetylglucosamine to mitigate Duchenne muscular dystrophy, from 2021-05-31 to 2024-05-30
  • Investigation of the role of galectin-3 and its ligands in skeletal muscle strength, regeneration, and pathology, from 2018-10-01 to 2023-03-31
Data provided by the Université Laval research projects registery