Professor Jérôme Frenette is a researcher with a background in physical therapy and post-graduate training in muscle physiology and immunology at the University of California in Los-Angeles. He is a full-time researcher at the Centre de recherche du CHU de Québec-Laval University, and full professor in the department of rehabilitation at Laval University’s School of Medicine. He has been the principal investigator on several CIHR and NSERC grants. Many of his publications, and one CIHR grant were recognized and rewarded as being among the best in the field of muscle physiology. He started his career as a researcher by investigating the roles played by blood cells and mechanical loading in models of tendon injury and muscle atrophy/regrowth. In 2005, he expanded his research program to include the Buruli Ulcer, which is caused by mycobacterium ulcerans, a neglected disease of wet tropical zones, that is closely related to tuberculosis and leprosy. His research group was the first to show that mycobacterium ulcerans and its toxin, mycolactone, extend well beyond the skin, and severely affect underlying skeletal muscles. Today, the focus of his research program is to understand the link between osteoporosis and muscle atrophy/disease through one common pathway i.e. the RANK/RANKL/OPG pathway. In collaboration with Duchenne muscular dystrophy foundations in Canada, the United States and Australia, as well as sustainable financial support from public and private sources, his team is developing new drugs that would potentially alleviate, in tandem, osteoporosis and muscle degeneration in Duchenne muscular dystrophy patients or other forms of bone and muscle diseases.

CHUL
2705, boulevard Laurier
P-09800
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 47779 / 47954
+1 418-654-2145
jerome.frenette@crchudequ...

Latest news

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Rancourt A, Dufresne SS, St-Pierre G, Levesque JC, Nakamura H, Kikuchi Y, Satoh MS, Frenette J, Sato S

Galectin-3 and N-acetylglucosamine promote myogenesis and improve skeletal muscle function in the mdx model of Duchenne muscular dystrophy

Journal Article

FASEB J, 2018.

Abstract | Links:

Mercier E, Tardif PA, Cameron PA, Emond M, Moore L, Mitra B, Ouellet MC, Frenette J, de Guise E, Le Sage N

Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury: a systematic review

Journal Article

Brain Inj, 32 (1), 2018.

Abstract | Links:

Mazon M, Julien J, Ung RV, Picard S, Hamoudi D, Tam R, Filiatrault J, Frenette J, Mac-Way F, Carreau M

Deletion of the Fanconi Anemia C Gene in Mice Leads to Skeletal Anomalies and Defective Bone Mineralization and Microarchitecture

Journal Article

J Bone Miner Res, 33 (11), 2018.

Abstract | Links:

Pryce BR, Al-Zahrani KN, Dufresne S, Belkina N, Labrèche C, Patino-Lopez G, Frenette J, Shaw S, Sabourin LA

Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness

Journal Article

Skelet Muscle, 7 (1), 2017.

Abstract | Links:

Dufresne SS, Boulanger-Piette A, Frenette J

Osteoprotegerin and β-Agonists Mitigate Muscular Dystrophy in Slow- and Fast-Twitch Skeletal Muscles

Journal Article

Am J Pathol, 187 (3), 2017.

Abstract | Links:

Dufresne SS, Boulanger-Piette A, Bosse S, Frenette J

Physiological role of receptor activator nuclear factor-kB (RANK) in denervation-induced muscle atrophy and dysfunction

Journal Article

Receptors Clin Investig, 3 (2), 2016.

Abstract | Links:

Dufresne SS, Frenette J, Dumont NA

[Inflammation and muscle regeneration, a double-edged sword]

Journal Article

Med Sci (Paris), 32 (6-7), 2016.

Abstract | Links:

Piette AB, Dufresne SS, Frenette J

A short-term statin treatment changes the contractile properties of fast-twitch skeletal muscles

Journal Article

BMC Musculoskelet Disord, 17 (1), 2016.

Abstract | Links:

Dufresne SS, Dumont NA, Boulanger-Piette A, Fajardo VA, Gamu D, Kake-Guena SA, David RO, Bouchard P, Lavergne E, Penninger JM, Pape PC, Tupling AR, Frenette J

Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles

Journal Article

Am J Physiol Cell Physiol, 310 (8), 2016.

Abstract | Links:

Dionne CE, Laurin D, Desrosiers T, Abdous B, Le Sage N, Frenette J, Mondor M, Pelletier S

Serum vitamin C and spinal pain: a nationwide study

Journal Article

Pain, 157 (11), 2016.

Abstract | Links:

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Active projects

  • Decipher the physiological functions of osteoprotegerin in skeletal and cardiac muscles, from 2023-04-01 to 2028-03-31
  • Development of a monosaccharide therapy using N-acetylglucosamine to mitigate Duchenne muscular dystrophy, from 2021-05-31 to 2024-05-30
  • Multifunctional properties of osteoprotegerin in muscular dystrophy and muscle repair, from 2020-04-01 to 2025-03-31

Recently finished projects

  • Deciphering the role of RANK/RANKL/OPG in skeletal muscle., from 2016-04-01 to 2022-03-31
  • Development of a glycobiology therapy to mitigate the progression of Duchenne muscular dystrophy, from 2021-07-01 to 2023-02-28
  • Does anti-RANKL therapy prevent glucocorticoid induced bone loss and promote muscle function in a mouse model of Duchenne muscular dystrophy, from 2021-04-01 to 2022-03-31
  • Investigation of the role of galectin-3 and its ligands in skeletal muscle strength, regeneration, and pathology, from 2018-10-01 to 2023-03-31
  • La protéine S100B est-elle un outil de dépistage valide pour réduire le nombre de tomodensitométries inutiles suite à un traumatisme cranio-cérébral léger?, from 2017-04-01 to 2022-01-31
Data provided by the Université Laval research projects registery