Professor Jérôme Frenette is a researcher with a background in physical therapy and post-graduate training in muscle physiology and immunology at the University of California in Los-Angeles. He is a full-time researcher at the Centre de recherche du CHU de Québec-Laval University, and full professor in the department of rehabilitation at Laval University’s School of Medicine. He has been the principal investigator on several CIHR and NSERC grants. Many of his publications, and one CIHR grant were recognized and rewarded as being among the best in the field of muscle physiology. He started his career as a researcher by investigating the roles played by blood cells and mechanical loading in models of tendon injury and muscle atrophy/regrowth. In 2005, he expanded his research program to include the Buruli Ulcer, which is caused by mycobacterium ulcerans, a neglected disease of wet tropical zones, that is closely related to tuberculosis and leprosy. His research group was the first to show that mycobacterium ulcerans and its toxin, mycolactone, extend well beyond the skin, and severely affect underlying skeletal muscles. Today, the focus of his research program is to understand the link between osteoporosis and muscle atrophy/disease through one common pathway i.e. the RANK/RANKL/OPG pathway. In collaboration with Duchenne muscular dystrophy foundations in Canada, the United States and Australia, as well as sustainable financial support from public and private sources, his team is developing new drugs that would potentially alleviate, in tandem, osteoporosis and muscle degeneration in Duchenne muscular dystrophy patients or other forms of bone and muscle diseases.

CHUL
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Québec, Québec
Canada G1V 4G2
78 entries « 2 of 8 »

Blais Lécuyer J, Mercier É, Tardif PA, Archambault PM, Chauny JM, Berthelot S, Frenette J, Perry J, Stiell I, Émond M, Lee J, Lang E, McRae A, Boucher V, Le Sage N

S100B protein level for the detection of clinically significant intracranial haemorrhage in patients with mild traumatic brain injury: a subanalysis of a prospective cohort study

Journal Article

Emerg Med J, 38 (4), 2021.

Abstract | Links:

Ouellet V, Boucher V, Beauchamp F, Neveu X, Archambault P, Berthelot S, Chauny JM, De Guise E, Émond M, Frenette J, Lang E, Lee J, Mercier , Moore L, Ouellet MC, Perry J, Le Sage N

Influence of concomitant injuries on post-concussion symptoms after a mild traumatic brain injury - a prospective multicentre cohort study

Journal Article

Brain Inj, 35 (9), 2021.

Abstract | Links:

Pryce BR, Labrèche C, Hamoudi D, Abou-Hamad J, Al-Zahrani KN, Hodgins JJ, Boulanger-Piette A, Bossé S, Balog-Alvarez C, Frénette J, Ardolino M, Kornegay JN, Sabourin LA

Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice

Journal Article

Biochim Biophys Acta Mol Cell Res, 1868 (2), 2021.

Abstract | Links:

Bouredji Z, Hamoudi D, Marcadet L, Argaw A, Frenette J

Testing the efficacy of a human full-length OPG-Fc analog in a severe model of cardiotoxin-induced skeletal muscle injury and repair

Journal Article

Mol Ther Methods Clin Dev, 21 , 2021.

Abstract | Links:

Hamoudi D, Bouredji Z, Marcadet L, Yagita H, Landry LB, Argaw A, Frenette J

Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice

Journal Article

Hum Mol Genet, 29 (3), 2020.

Abstract | Links:

Le Sage N, Tardif PA, Frenette J, Emond M, Chauny JM, Moore L, Archambault P, Perry J, Boulanger-Piette A

Detection of S-100β Protein in Plasma and Urine After a Mild Traumatic Brain Injury

Journal Article

Can J Neurol Sci, 46 (5), 2019.

Abstract | Links:

Hamoudi D, Marcadet L, Piette Boulanger A, Yagita H, Bouredji Z, Argaw A, Frenette J

An anti-RANKL treatment reduces muscle inflammation and dysfunction and strengthens bone in dystrophic mice

Journal Article

Hum Mol Genet, 28 (18), 2019.

Abstract | Links:

Boulanger Piette A, Hamoudi D, Marcadet L, Kyomi Labelle F, Ovidiu David R, Bosse S, Argaw A, Frenette J

Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice

Journal Article

PLoS One, 13 (6), 2018.

Abstract | Links:

Mercier E, Tardif PA, Cameron P, Batomen Kuimi BL, Emond M, Moore L, Mitra B, Frenette J, de Guise E, Ouellet MC, Bordeleau M, Le Sage N

Prognostic Value of S-100β Protein for Prediction of Post-Concussion Symptoms after a Mild Traumatic Brain Injury: Systematic Review and Meta-Analysis

Journal Article

J Neurotrauma, 35 (4), 2018.

Abstract | Links:

Mazon M, Julien J, Ung RV, Picard S, Hamoudi D, Tam R, Filiatrault J, Frenette J, Mac-Way F, Carreau M

Deletion of the Fanconi Anemia C Gene in Mice Leads to Skeletal Anomalies and Defective Bone Mineralization and Microarchitecture

Journal Article

J Bone Miner Res, 33 (11), 2018.

Abstract | Links:

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Active projects

  • Decipher the physiological functions of osteoprotegerin in skeletal and cardiac muscles, from 2023-04-01 to 2028-03-31
  • Multifunctional properties of osteoprotegerin in muscular dystrophy and muscle repair, from 2020-04-01 to 2025-03-31

Recently finished projects

  • Development of a glycobiology therapy to mitigate the progression of Duchenne muscular dystrophy, from 2021-07-01 to 2023-02-28
  • Development of a monosaccharide therapy using N-acetylglucosamine to mitigate Duchenne muscular dystrophy, from 2021-05-31 to 2024-05-30
  • Investigation of the role of galectin-3 and its ligands in skeletal muscle strength, regeneration, and pathology, from 2018-10-01 to 2023-03-31
Data provided by the Université Laval research projects registery