Professor Jérôme Frenette is a researcher with a background in physical therapy and post-graduate training in muscle physiology and immunology at the University of California in Los-Angeles. He is a full-time researcher at the Centre de recherche du CHU de Québec-Laval University, and full professor in the department of rehabilitation at Laval University’s School of Medicine. He has been the principal investigator on several CIHR and NSERC grants. Many of his publications, and one CIHR grant were recognized and rewarded as being among the best in the field of muscle physiology. He started his career as a researcher by investigating the roles played by blood cells and mechanical loading in models of tendon injury and muscle atrophy/regrowth. In 2005, he expanded his research program to include the Buruli Ulcer, which is caused by mycobacterium ulcerans, a neglected disease of wet tropical zones, that is closely related to tuberculosis and leprosy. His research group was the first to show that mycobacterium ulcerans and its toxin, mycolactone, extend well beyond the skin, and severely affect underlying skeletal muscles. Today, the focus of his research program is to understand the link between osteoporosis and muscle atrophy/disease through one common pathway i.e. the RANK/RANKL/OPG pathway. In collaboration with Duchenne muscular dystrophy foundations in Canada, the United States and Australia, as well as sustainable financial support from public and private sources, his team is developing new drugs that would potentially alleviate, in tandem, osteoporosis and muscle degeneration in Duchenne muscular dystrophy patients or other forms of bone and muscle diseases.

CHUL
2705, boulevard Laurier
P-09800
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 47779 / 47954
+1 418-654-2145
jerome.frenette@crchudequ...

Latest news

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Jayash SN, Hamoudi D, Stephen LA, Argaw A, Huesa C, Joseph S, Wong SC, Frenette J, Farquharson C

Anti-RANKL Therapy Prevents Glucocorticoid-Induced Bone Loss and Promotes Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy

Journal Article

Calcif Tissue Int, 2023.

Abstract | Links:

Peyrel P, Mauriège P, Frenette J, Laflamme N, Greffard K, Dufresne SS, Huth C, Bergeron J, Joanisse DR

Impact of statin withdrawal on perceived and objective muscle function

Journal Article

PLoS One, 18 (6), 2023.

Abstract | Links:

Marcadet L, Juracic ES, Khan N, Bouredji Z, Yagita H, Ward LM, Tupling AR, Argaw A, Frenette J

RANKL Inhibition Reduces Cardiac Hypertrophy in mdx Mice and Possibly in Children with Duchenne Muscular Dystrophy

Journal Article

Cells, 12 (11), 2023.

Abstract | Links:

Bouredji Z, Argaw A, Frenette J

The inflammatory response, a mixed blessing for muscle homeostasis and plasticity

Journal Article

Front Physiol, 13 , 2022.

Abstract | Links:

Le Sage N, Sage NL, Chauny JM, Berthelot S, Archambault P, Neveu X, Moore L, Boucher V, Frenette J, De Guise É, Ouellet MC, Lee J, McRae AD, Lang E, Émond M, Mercier É, Tardif PA, Swaine B, Cameron P, Perry JJ

Post-Concussion Symptoms Rule: Derivation and Validation of a Clinical Decision Rule for Early Prediction of Persistent Symptoms after a Mild Traumatic Brain Injury

Journal Article

J Neurotrauma, 39 (19-20), 2022.

Abstract | Links:

Marcadet L, Bouredji Z, Argaw A, Frenette J

The Roles of RANK/RANKL/OPG in Cardiac, Skeletal, and Smooth Muscles in Health and Disease

Journal Article

Front Cell Dev Biol, 10 , 2022.

Abstract | Links:

Dionne CE, Laurin D, Desrosiers T, Abdous B, Sage NL, Frenette J, Mondor M

The Association Between Self-Reported Cigarette Smoking and Spinal Pain is Not Explained by Serum Cotinine Levels

Journal Article

Ann Epidemiol, 67 , 2022.

Abstract | Links:

Bouredji Z, Hamoudi D, Marcadet L, Argaw A, Frenette J

Testing the efficacy of a human full-length OPG-Fc analog in a severe model of cardiotoxin-induced skeletal muscle injury and repair

Journal Article

Mol Ther Methods Clin Dev, 21 , 2021.

Abstract | Links:

Ouellet V, Boucher V, Beauchamp F, Neveu X, Archambault P, Berthelot S, Chauny JM, De Guise E, Émond M, Frenette J, Lang E, Lee J, Mercier , Moore L, Ouellet MC, Perry J, Le Sage N

Influence of concomitant injuries on post-concussion symptoms after a mild traumatic brain injury - a prospective multicentre cohort study

Journal Article

Brain Inj, 35 (9), 2021.

Abstract | Links:

Pryce BR, Labrèche C, Hamoudi D, Abou-Hamad J, Al-Zahrani KN, Hodgins JJ, Boulanger-Piette A, Bossé S, Balog-Alvarez C, Frénette J, Ardolino M, Kornegay JN, Sabourin LA

Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice

Journal Article

Biochim Biophys Acta Mol Cell Res, 1868 (2), 2021.

Abstract | Links:

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Active projects

  • Decipher the physiological functions of osteoprotegerin in skeletal and cardiac muscles, from 2023-04-01 to 2028-03-31
  • Development of a monosaccharide therapy using N-acetylglucosamine to mitigate Duchenne muscular dystrophy, from 2021-05-31 to 2024-05-30
  • Multifunctional properties of osteoprotegerin in muscular dystrophy and muscle repair, from 2020-04-01 to 2025-03-31

Recently finished projects

  • Deciphering the role of RANK/RANKL/OPG in skeletal muscle., from 2016-04-01 to 2022-03-31
  • Development of a glycobiology therapy to mitigate the progression of Duchenne muscular dystrophy, from 2021-07-01 to 2023-02-28
  • Does anti-RANKL therapy prevent glucocorticoid induced bone loss and promote muscle function in a mouse model of Duchenne muscular dystrophy, from 2021-04-01 to 2022-03-31
  • Investigation of the role of galectin-3 and its ligands in skeletal muscle strength, regeneration, and pathology, from 2018-10-01 to 2023-03-31
  • La protéine S100B est-elle un outil de dépistage valide pour réduire le nombre de tomodensitométries inutiles suite à un traumatisme cranio-cérébral léger?, from 2017-04-01 to 2022-01-31
Data provided by the Université Laval research projects registery