Professor Jérôme Frenette is a researcher with a background in physical therapy and post-graduate training in muscle physiology and immunology at the University of California in Los-Angeles. He is a full-time researcher at the Centre de recherche du CHU de Québec-Laval University, and full professor in the department of rehabilitation at Laval University’s School of Medicine. He has been the principal investigator on several CIHR and NSERC grants. Many of his publications, and one CIHR grant were recognized and rewarded as being among the best in the field of muscle physiology. He started his career as a researcher by investigating the roles played by blood cells and mechanical loading in models of tendon injury and muscle atrophy/regrowth. In 2005, he expanded his research program to include the Buruli Ulcer, which is caused by mycobacterium ulcerans, a neglected disease of wet tropical zones, that is closely related to tuberculosis and leprosy. His research group was the first to show that mycobacterium ulcerans and its toxin, mycolactone, extend well beyond the skin, and severely affect underlying skeletal muscles. Today, the focus of his research program is to understand the link between osteoporosis and muscle atrophy/disease through one common pathway i.e. the RANK/RANKL/OPG pathway. In collaboration with Duchenne muscular dystrophy foundations in Canada, the United States and Australia, as well as sustainable financial support from public and private sources, his team is developing new drugs that would potentially alleviate, in tandem, osteoporosis and muscle degeneration in Duchenne muscular dystrophy patients or other forms of bone and muscle diseases.
2705, boulevard Laurier
P-09800
Québec, Québec
Canada G1V 4G2
Latest news
- Un projet mené par Sachiko Sato soutenu par la fondation Jesse’s Journey 2021-05-25
- Quatorze chercheurs du CRCHU reçoivent près de 9 millions de dollars de subvention des IRSC 2020-02-28
- Un sucre contre la dystrophie musculaire – Un supplément alimentaire dérivé du glucose produit des effets spectaculaires chez des souris atteintes de dystrophie musculaire de Duchenne 2018-06-28
- Argaw, AntenehEmployeeCHUL+1 418-525-4444, extension 48840Anteneh.Argaw@crchudequebec.ulaval.ca
2705, boulevard Laurier
P-09800
Québec, Québec
Canada G1V 4G2 - Bouredji, ZinebDoctoral studentCHUL+1 418-525-4444, extension 47954zineb.bouredji.1@ulaval.cazineb.bouredji@crchudequebec.ulaval.ca
2705, boul. Laurier
P-09800
Québec, Québec
Canada G1V 4G2 - Marcadet, LaetitiaDoctoral studentCHUL+1 418-525-4444, extension 47954laetitia.marcadet.1@ulaval.calaetitia.marcadet@crchudequebec.ulaval.ca
2705, Boul. Laurier
P-09800
Québec, QC
Canada G1V 4G2
The inflammatory response, a mixed blessing for muscle homeostasis and plasticity
Journal ArticleFront Physiol, 13 , 2022.
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Post-Concussion Symptoms Rule: Derivation and Validation of a Clinical Decision Rule for Early Prediction of Persistent Symptoms after a Mild Traumatic Brain Injury
Journal ArticleJ Neurotrauma, 39 (19-20), 2022.
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The Roles of RANK/RANKL/OPG in Cardiac, Skeletal, and Smooth Muscles in Health and Disease
Journal ArticleFront Cell Dev Biol, 10 , 2022.
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The Association Between Self-Reported Cigarette Smoking and Spinal Pain is Not Explained by Serum Cotinine Levels
Journal ArticleAnn Epidemiol, 67 , 2022.
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Testing the efficacy of a human full-length OPG-Fc analog in a severe model of cardiotoxin-induced skeletal muscle injury and repair
Journal ArticleMol Ther Methods Clin Dev, 21 , 2021.
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Influence of concomitant injuries on post-concussion symptoms after a mild traumatic brain injury - a prospective multicentre cohort study
Journal ArticleBrain Inj, 35 (9), 2021.
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Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice
Journal ArticleBiochim Biophys Acta Mol Cell Res, 1868 (2), 2021.
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Post-concussion symptoms in sports-related mild traumatic brain injury compared to non-sports-related mild traumatic brain injury
Journal ArticleCJEM, 23 (2), 2021.
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S100B protein level for the detection of clinically significant intracranial haemorrhage in patients with mild traumatic brain injury: a subanalysis of a prospective cohort study
Journal ArticleEmerg Med J, 38 (4), 2021.
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Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice
Journal ArticleHum Mol Genet, 29 (3), 2020.
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Active projects
- Development of a monosaccharide therapy using N-acetylglucosamine to mitigate Duchenne muscular dystrophy, from 2021-05-31 to 2024-05-30
- Investigation of the role of galectin-3 and its ligands in skeletal muscle strength, regeneration, and pathology, from 2018-10-01 to 2023-03-31
- Multifunctional properties of osteoprotegerin in muscular dystrophy and muscle repair, from 2020-04-01 to 2025-03-31
Recently finished projects
- Deciphering the role of RANK/RANKL/OPG in skeletal muscle., from 2016-04-01 to 2022-03-31
- Development of a glycobiology therapy to mitigate the progression of Duchenne muscular dystrophy, from 2021-07-01 to 2023-02-28
- Development of a therapy for Duchenne muscular dystrophy using N-acetylglucosamine, from 2019-06-15 to 2021-03-31
- Does anti-RANKL therapy prevent glucocorticoid induced bone loss and promote muscle function in a mouse model of Duchenne muscular dystrophy, from 2021-04-01 to 2022-03-31
- Does anti-RANKL therapy prevent glucocorticoid induced bone loss in a mouse model of Duchenne muscular dystrophy?, from 2020-10-01 to 2021-07-31
- La protéine S100B est-elle un outil de dépistage valide pour réduire le nombre de tomodensitométries inutiles suite à un traumatisme cranio-cérébral léger?, from 2017-04-01 to 2022-01-31