The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface.  Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases.  His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.

Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.

CHUL
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46319
+1 418-654-2765
jean.sevigny@crchudequebe...

Latest news

293 entries « ‹ 3 of 30 › »

Salem M, Lecka J, Pelletier J, Gomes Marconato D, Dumas A, Vallières L, Brochu G, Robaye B, Jobin C, Sévigny J

NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD

Journal Article

Gut, 71 (1), 2022.

Abstract | Links:

Schäkel L, Mirza S, Pietsch M, Lee SY, Keuler T, Sylvester K, Pelletier J, Sévigny J, Pillaiyar T, Namasivayam V, Gütschow M, Müller CE

2-Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors

Journal Article

Arch Pharm (Weinheim), 354 (12), 2021.

Abstract | Links:

Iqbal J, Jacob C, Sévigny J

Editorial: Metalloenzymes: Potential Drug Targets

Journal Article

Front Pharmacol, 12 , 2021.

| Links:

Haas CB, Lovászi M, Pacher P, de Souza PO, Pelletier J, Leite RO, Sévigny J, Németh Z, Braganhol E, Haskó G

Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammation

Journal Article

Purinergic Signal, 17 (4), 2021.

Abstract | Links:

Murtaza A, Afzal S, Zaman G, Saeed A, Pelletier J, Sévigny J, Iqbal J, Hassan A

Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitor

Journal Article

Bioorg Chem, 115 , 2021.

Abstract | Links:

Dias AF, Scholl JN, Moritz CEJ, Kagami LP, das Neves GM, Eifler-Lima VL, Cruz-López O, Conejo-García A, Sévigny J, Battastini AMO, Campos JM, Figueiró F

New insights into cytotoxic mechanisms of bozepinib against glioblastoma

Journal Article

Eur J Pharm Sci, 162 , 2021.

Abstract | Links:

Schachter J, Alvarez CL, Bazzi Z, Faillace MP, Corradi G, Hattab C, Rinaldi DE, Gonzalez-Lebrero R, Molineris MP, Sévigny J, Ostuni MA, Schwarzbaum PJ

Extracellular ATP hydrolysis in Caco-2 human intestinal cell line

Journal Article

Biochim Biophys Acta Biomembr, 1863 (10), 2021.

Abstract | Links:

Aziz H, Mahmood A, Zaib S, Saeed A, El-Seedi HR, Pelletier J, Sévigny J, Iqbal J

Synthesis, characterization, alkaline phosphatase inhibition assay and molecular modeling studies of 1-benzylidene-2-(4-tert- butylthiazol-2-yl) hydrazines

Journal Article

J Biomol Struct Dyn, 39 (16), 2021.

Abstract | Links:

Babou Kammoe RB, Kauffenstein G, Pelletier J, Robaye B, Sevigny J

NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female

Journal Article

Biomolecules, 11 (2), 2021.

Abstract | Links:

Rodriguez-Martinez A, Trapero C, Vidal A, Piulats JM, Gomez de Aranda I, Sevigny J, Fernandez-Montoli ME, Ponce J, Matias-Guiu X, Martin-Satue M

Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes

Journal Article

J Pers Med, 11 (5), 2021.

Abstract | Links:

293 entries « ‹ 3 of 30 › »
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Active projects

  • A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease, from 2021-10-01 to 2026-09-30
  • Ectonucleotidases and Extracellular Nucleotides in Smooth Muscle Cell Contraction, from 2023-04-01 to 2028-03-31
  • Novel P2Y6 antagonists as a potential therapy for inflammatory bowel disease, from 2021-07-01 to 2025-06-30
  • Scaling up the production of recombinant human NTPDase8 in CHO expression system for in vivo testing, from 2023-09-01 to 2024-03-31

Recently finished projects

  • A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, from 2018-04-01 to 2023-03-31
  • Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction., from 2016-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery