The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface. Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases. His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.
Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
Latest news
- Une subvention de recherche de Crohn et Colite Canada pour Jean Sévigny 2021-10-25
- Près de 9,4 millions de subventions des IRSC pour les projets de 14 chercheurs du CRCHU 2021-08-03
- Maladies inflammatoires de l’intestin : un nouveau mécanisme protecteur découvert par une équipe du Centre de recherche du CHU de Québec-Université Laval 2021-02-17
- Alvarado Aparicio, VictorInternCHUL+1 418-525-4444, extension 42296
2705, boulevard Laurier
T1-49
Québec, QC
Canada G1V 4G2 - Babou Kammoe, Romuald BriceDoctoral studentCHUL+1 418-525-4444, extension 42296Romuald.Babou@crchudequebec.ulaval.ca
2705 Boulevard Laurier
T1-49
Québec, QC
Canada G1v 4G2 - Diallo, Aissatou BillyInternCHUL+1 418-525-4444, extension 42296aissatou-billy.diallo@crchudequebec.ulaval.ca
2705, boulevard Laurier
T1-49
Québec, QC
Canada G1V 4G2 - Guedes Manzoni, AlessandraDoctoral studentCHUL
2705, boulevard Laurier
T1-49
Québec, QC
Canada G1V 4G2850 Rue Grandjean+1 418-525-4444, extension 42296alessandra.manzoni@crchudequebec.ulaval.ca
Québec, QC
Canada G1X 3W5 - Mamatova, IrodakhonEmployeeCHUL+1 418-525-4444, extension 42296irodakhon.mamatova@crchudequebec.ulaval.ca
2705, boulevard Laurier
T1-49
Québec, QC
Canada G1V 4G2 - Ouattara, Abdoul KarimDoctoral studentCHULabdoul-karim.ouattara.1@ulaval.caabdoul-karim.ouattara@crchudequebec.ulaval.ca
2705 Boulevard Laurier
T1-49
Québec, QC
Canada G1V 4G2 - Pelletier, JulieEmployeeCHUL+1 418-525-4444, extension 42296+1 418-654-2765julie.pelletier@crchudequebec.ulaval.ca
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2 - Pereira de Sousa, Roberto AugustoInternCHUL+1 418-525-4444, extension 42296roberto-augusto.pereira-de-sousa@crchudequebec.ulaval.ca
2705, boulevard Laurier
T1-49
Québec, QC
Canada G1V 4G2 - Rahimi, SinaDoctoral studentCHUL+1 418-525-4444, extension 42296sina.rahimi@crchudequebec.ulaval.ca
2705, boulevard Laurier
T1-49
Québec, QC
Canada G1V 4G2 - Rana, MananInternCHUL+1 418-525-4444, extension 42296
2705, boulevard Laurier
T1-49
Québec, QC
Canada G1V 4G2 - Salarpour, FatemehDoctoral studentCHUL+1 418-525-4444, extension 42296fatemeh.salarpour@crchudequebec.ulaval.ca
2705, boulevard Laurier
T1-49
Québec, QC
Canada G1V 4G2 - Turcitu, RaduMaster studentCHUL+1 418-525-4444, extension 42296radu.turcitu@crchudequebec.ulaval.ca
2705, boulevard Laurier
T1-49
Québec, QC
Canada G1V 4G2 - Vigiani, EricaInternCHUL+1 418-525-4444erica.vigiani@crchudequebec.ulaval.ca
2705, boulevard Laurier
Québec, QC
Canada G1V 4G2
Purification and Identification by Immunological Techniques of Different Isoforms of Mammalian ATP Diphosphohydrolases
Book ChapterPlesner L, Kirley TL, Knowles AF (Ed.): Ecto-ATPases, pp. 143-151, Boston, MA, Springer, 1997, ISBN: 9780306455841.
Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques
Journal ArticleBiochim Biophys Acta, 1334 (1), 1997.
Purification, characterization, and localization of two ATP diphosphohydrolase isoforms in bovine heart
Journal ArticleAm J Physiol, 273 (2 Pt 2), 1997.
Purification and immunohistochemical localization of the ATP diphosphohydrolase in bovine lungs
Journal ArticleAm J Physiol, 272 (5 Pt 1), 1997.
ATP-diphosphohydrolases, apyrases, and nucleotide phosphohydrolases: Biochemical properties and functions
Book ChapterLee AG (Ed.): Biomembranes: A Multi-Volume Treatise, volume 5 : ATPases, pp. 369-401, Greenwich, CT, JAI Press, 1996, ISBN: 9781559386623.
Identification and characterization of CD39/vascular ATP diphosphohydrolase
Journal ArticleJ Biol Chem, 271 (51), 1996.
Hydrolysis of P2-purinoceptor agonists by a purified ectonucleotidase from the bovine aorta, the ATP-diphosphohydrolase
Journal ArticleBiochem Pharmacol, 51 (11), 1996.
Purification of pancreas type-I ATP diphosphohydrolase and identification by affinity labelling with the 5'-p-fluorosulphonylbenzoyladenosine ATP analogue
Journal ArticleBiochem J, 312 ( Pt 2) , 1995.
Le monde des nucléotides extracellulaires
Journal ArticleMed Sci (Paris), 10 (8-9), 1994.
Influence of diet on plasma steroids and sex hormone-binding globulin levels in adult men
Journal ArticleJ Steroid Biochem, 32 (6), 1989.
Active projects
- A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease, from 2021-10-01 to 2026-09-30
- Ectonucleotidases and Extracellular Nucleotides in Smooth Muscle Cell Contraction, from 2023-04-01 to 2028-03-31
- Novel P2Y6 antagonists as a potential therapy for inflammatory bowel disease, from 2021-07-01 to 2024-06-30
Recently finished projects
- A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, from 2018-04-01 to 2023-03-31
- Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction., from 2016-04-01 to 2022-03-31