The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface.  Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases.  His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.

Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.

CHUL
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46319
+1 418-654-2765
jean.sevigny@crchudequebe...

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293 entries « ‹ 29 of 30 › »

Sévigny J, Grondin G, Gendron FP, Roy J, Beaudoin AR

Demonstration and immunolocalization of ATP diphosphohydrolase in the pig digestive system

Journal Article

Am J Physiol, 275 (3), 1998.

Abstract | Links:

Beaudoin AR, Grondin G, Sévigny J

Distribution of Different ATP-Diphosphohydrolase Isoforms in Mammalian Organs

Book Chapter

Plesner L, Kirley TL, Knowles AF (Ed.): Ecto-ATPases, pp. 33-40, Boston, MA, Springer, 1997, ISBN: 9780306455841.

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Kaczmarek E, Siegel JB, Sévigny J, Koziak K, Hancock WW, Beaudoin A, Bach FH, Robson SC

Vascular ATP Diphosphohydrolase (CD39/ATPDase)

Book Chapter

Plesner L, Kirley TL, Knowles AF (Ed.): Ecto-ATPases, pp. 171-185, Boston, MA, Springer, 1997, ISBN: 9780306455841.

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Sévigny J, Dumas F, Beaudoin AR

Purification and Identification by Immunological Techniques of Different Isoforms of Mammalian ATP Diphosphohydrolases

Book Chapter

Plesner L, Kirley TL, Knowles AF (Ed.): Ecto-ATPases, pp. 143-151, Boston, MA, Springer, 1997, ISBN: 9780306455841.

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Sévigny J, Levesque FP, Grondin G, Beaudoin AR

Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques

Journal Article

Biochim Biophys Acta, 1334 (1), 1997.

Abstract | Links:

Beaudoin AR, Sévigny J, Grondin G, Daoud S, Levesque FP

Purification, characterization, and localization of two ATP diphosphohydrolase isoforms in bovine heart

Journal Article

Am J Physiol, 273 (2 Pt 2), 1997.

Abstract | Links:

Sévigny J, Picher M, Grondin G, Beaudoin AR

Purification and immunohistochemical localization of the ATP diphosphohydrolase in bovine lungs

Journal Article

Am J Physiol, 272 (5 Pt 1), 1997.

Abstract | Links:

Beaudoin AR, Sévigny J, Picher M

ATP-diphosphohydrolases, apyrases, and nucleotide phosphohydrolases: Biochemical properties and functions

Book Chapter

Lee AG (Ed.): Biomembranes: A Multi-Volume Treatise, volume 5 : ATPases, pp. 369-401, Greenwich, CT, JAI Press, 1996, ISBN: 9781559386623.

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Kaczmarek E, Koziak K, Sévigny J, Siegel JB, Anrather J, Beaudoin AR, Bach FH, Robson SC

Identification and characterization of CD39/vascular ATP diphosphohydrolase

Journal Article

J Biol Chem, 271 (51), 1996.

Abstract | Links:

Picher M, Sévigny J, D'Orléans-Juste P, Beaudoin AR

Hydrolysis of P2-purinoceptor agonists by a purified ectonucleotidase from the bovine aorta, the ATP-diphosphohydrolase

Journal Article

Biochem Pharmacol, 51 (11), 1996.

Abstract | Links:

293 entries « ‹ 29 of 30 › »
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Active projects

  • A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease, from 2021-10-01 to 2026-09-30
  • Ectonucleotidases and Extracellular Nucleotides in Smooth Muscle Cell Contraction, from 2023-04-01 to 2028-03-31
  • Novel P2Y6 antagonists as a potential therapy for inflammatory bowel disease, from 2021-07-01 to 2025-06-30
  • Scaling up the production of recombinant human NTPDase8 in CHO expression system for in vivo testing, from 2023-09-01 to 2024-03-31

Recently finished projects

  • A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, from 2018-04-01 to 2023-03-31
  • Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction., from 2016-04-01 to 2022-03-31
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