The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface.  Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases.  His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.

Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.

CHUL
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
299 entries « 29 of 30 »

Imai M, Takigami K, Guckelberger O, Enjyoji K, Smith RN, Lin Y, Csizmadia E, Sévigny J, Rosenberg RD, Bach FH, Robson SC

Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection

Journal Article

Mol Med, 5 (11), 1999.

Abstract | Links:

Enjyoji K, Sévigny J, Lin Y, Frenette PS, Christie PD, Esch JS, Imai M, Edelberg JM, Rayburn H, Lech M, Beeler DL, Csizmadia E, Wagner DD, Robson SC, Rosenberg RD

Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation

Journal Article

Nat Med, 5 (9), 1999.

Abstract | Links:

Koziak K, Sévigny J, Robson SC, Siegel JB, Kaczmarek E

Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes

Journal Article

Thromb Haemost, 82 (5), 1999.

Abstract | Links:

Imai M, Kaczmarek E, Koziak K, Sévigny J, Goepfert C, Guckelberger O, Csizmadia E, Schulte am Esch J, Robson SC

Suppression of ATP diphosphohydrolase/CD39 in human vascular endothelial cells

Journal Article

Biochemistry, 38 (41), 1999.

Abstract | Links:

Schulte am Esch J, Sévigny J, Kaczmarek E, Siegel JB, Imai M, Koziak K, Beaudoin AR, Robson SC

Structural elements and limited proteolysis of CD39 influence ATP diphosphohydrolase activity

Journal Article

Biochemistry, 38 (8), 1999.

Abstract | Links:

Beaudoin AR, Sévigny J, Gendron FP, St George M, Leclerc MC

Prevention and reversal of thrombotic and inflammatory processes

Journal Article

Emerging therapeutic targets, 2 (1), 1998.

| Links:

Sévigny J, Grondin G, Gendron FP, Roy J, Beaudoin AR

Demonstration and immunolocalization of ATP diphosphohydrolase in the pig digestive system

Journal Article

Am J Physiol, 275 (3), 1998.

Abstract | Links:

Beaudoin AR, Sévigny J, Grondin G, Daoud S, Levesque FP

Purification, characterization, and localization of two ATP diphosphohydrolase isoforms in bovine heart

Journal Article

Am J Physiol, 273 (2 Pt 2), 1997.

Abstract | Links:

Sévigny J, Picher M, Grondin G, Beaudoin AR

Purification and immunohistochemical localization of the ATP diphosphohydrolase in bovine lungs

Journal Article

Am J Physiol, 272 (5 Pt 1), 1997.

Abstract | Links:

Sévigny J, Levesque FP, Grondin G, Beaudoin AR

Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques

Journal Article

Biochim Biophys Acta, 1334 (1), 1997.

Abstract | Links:

299 entries « 29 of 30 »
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Active projects

  • A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease, from 2021-10-01 to 2026-09-30
  • Ectonucleotidases and Extracellular Nucleotides in Smooth Muscle Cell Contraction, from 2023-04-01 to 2028-03-31
  • Novel P2Y6 antagonists as a potential therapy for inflammatory bowel disease, from 2021-07-01 to 2025-06-30
  • Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines, from 2024-04-01 to 2030-03-31

Recently finished projects

  • A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, from 2018-04-01 to 2023-03-31
  • Scaling up the production of recombinant human NTPDase8 in CHO expression system for in vivo testing, from 2023-09-01 to 2024-03-31
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