The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface. Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases. His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.
Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.
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Synthesis and structure-activity relationships of ticlopidine derivatives and analogs as inhibitors of ectonucleotidase CD39
Journal ArticleBioorg Chem, 135 , 2023.
Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors
Journal ArticleStem Cell Res Ther, 14 (1), 2023.
Stomach-derived human insulin-secreting organoids restore glucose homeostasis
Journal ArticleNat Cell Biol, 25 (5), 2023.
Tumor-neutrophil crosstalk promotes in vitro and in vivo glioblastoma progression
Journal ArticleFront Immunol, 14 , 2023.
Synthesis and biological evaluation of sulfamate derivatives as inhibitors of carbonic anhydrases II and IX
Journal ArticleMed Chem Res, 32 (5), 2023.
Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme
Journal ArticlePurinergic Signal, 2023.
NTPDase1/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flow
Journal ArticleInt J Mol Sci, 24 (20), 2023.
Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors
Journal ArticleRSC Adv, 13 (42), 2023.
Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) - a promising target for the immunotherapy of cancer
Journal ArticleFront Immunol, 14 , 2023.
Synthesis of Thieno[3,2-d]pyrimidine Derivatives through Sequential SN Ar and Suzuki Reactions as Selective h-NTPDase Inhibitors
Journal ArticleChemMedChem, 18 (14), 2023.
Active projects
- A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease, from 2021-10-01 to 2026-09-30
- Ectonucleotidases and Extracellular Nucleotides in Smooth Muscle Cell Contraction, from 2023-04-01 to 2028-03-31
- Novel P2Y6 antagonists as a potential therapy for inflammatory bowel disease, from 2021-07-01 to 2025-06-30
- Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines, from 2024-04-01 to 2030-03-31
Recently finished projects
- A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, from 2018-04-01 to 2023-03-31
- Scaling up the production of recombinant human NTPDase8 in CHO expression system for in vivo testing, from 2023-09-01 to 2024-03-31