The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface. Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases. His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.
Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
Latest news
- Une subvention de recherche de Crohn et Colite Canada pour Jean Sévigny 2021-10-25
- Près de 9,4 millions de subventions des IRSC pour les projets de 14 chercheurs du CRCHU 2021-08-03
- Maladies inflammatoires de l’intestin : un nouveau mécanisme protecteur découvert par une équipe du Centre de recherche du CHU de Québec-Université Laval 2021-02-17
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Identification of thienopyrimidine glycinates as selective inhibitors for h-NTPDases
Journal ArticleBioorg Chem, 129 , 2022.
Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists
Journal ArticleBioorg Med Chem Lett, 75 , 2022.
Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 - a promising target for cancer immunotherapy
Journal ArticleJ Immunother Cancer, 10 (8), 2022.
Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors
Journal ArticleACS Omega, 7 (30), 2022.
Homeostasis of extracellular ATP in uninfected RBCs from a Plasmodium falciparum culture and derived microparticles
Journal ArticleBiochim Biophys Acta Biomembr, 1864 (10), 2022.
The Purinergic Receptor P2X4 Promotes Th17 Activation and the Development of Arthritis
Journal ArticleJ Immunol, 208 (5), 2022.
Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitors
Journal ArticleBioorg Chem, 118 , 2022.
NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD
Journal ArticleGut, 71 (1), 2022.
2-Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors
Journal ArticleArch Pharm (Weinheim), 354 (12), 2021.
Editorial: Metalloenzymes: Potential Drug Targets
Journal ArticleFront Pharmacol, 12 , 2021.
Active projects
- A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease, from 2021-10-01 to 2026-09-30
- Ectonucleotidases and Extracellular Nucleotides in Smooth Muscle Cell Contraction, from 2023-04-01 to 2028-03-31
- Novel P2Y6 antagonists as a potential therapy for inflammatory bowel disease, from 2021-07-01 to 2024-06-30
Recently finished projects
- A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, from 2018-04-01 to 2023-03-31
- Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction., from 2016-04-01 to 2022-03-31