The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface.  Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases.  His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.

Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.

CHUL
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46319
+1 418-654-2765
jean.sevigny@crchudequebe...

Latest news

286 entries « ‹ 1 of 29 › »

Younus HA, Saeed M, Mahmood A, Jadoon MSK, Hameed A, Asari A, Mohamad H, Pelletier J, Sévigny J, Iqbal J, Al-Rashida M

Exploring chromone sulfonamides and sulfonylhydrazones as highly selective ectonucleotidase inhibitors: Synthesis, biological evaluation and in silico study

Journal Article

Bioorg Chem, 134 , 2023.

Abstract | Links:

Naasani LIS, Sévigny J, Moulin VJ, Wink MR

UTP increases wound healing in the self assembled skin substitute (SASS)

Journal Article

J Cell Commun Signal, 2023.

Abstract | Links:

Naasani LIS, Azevedo JG, Sévigny J, Franco de Oliveira T, Maria-Engler SS, Wink MR

Epidermal melanocytes metabolize extracellular nucleotides by purinergic enzymes

Journal Article

Biochem Cell Biol, 2023.

Abstract | Links:

Shahin AI, Zaraei SO, AlKubaisi BO, Ullah S, Anbar HS, El-Gamal R, Menon V, Abdel-Maksoud MS, Oh CH, El-Awady R, Gelsleichter NE, Pelletier J, Sévigny J, Iqbal J, Al-Tel TH, El-Gamal MI

Design and synthesis of new adamantyl derivatives as promising antiproliferative agents

Journal Article

Eur J Med Chem, 246 , 2023.

Abstract | Links:

da Silva W, Ribeiro IC, Agripino JM, da Silva VHF, de Souza LÂ, Oliveira TA, Bressan GC, Vasconcellos RS, Dumas C, Pelletier J, Sévigny J, Papadopoulou B, Fietto JLR

Leishmania infantum NTPDase1 and NTPDase2 play an important role in infection and nitric oxide production in macrophages

Journal Article

Acta Trop, 237 , 2023.

Abstract | Links:

Naasani LIS, Pretto L, Zanatelli C, Paim TC, Souza AFD, Pase PF, Fernandes MDC, Sévigny J, Wink MR

Bioscaffold developed with decellularized human amniotic membrane seeded with mesenchymal stromal cells: assessment of efficacy and safety profiles in a second-degree burn preclinical model

Journal Article

Biofabrication, 15 (1), 2022.

Abstract | Links:

Begum Z, Ullah S, Akram M, Uzair M, Ullah F, Ahsanullah , Pelletier J, Sévigny J, Iqbal J, Hassan A

Identification of thienopyrimidine glycinates as selective inhibitors for h-NTPDases

Journal Article

Bioorg Chem, 129 , 2022.

Abstract | Links:

Jung YH, Shah Q, Lewicki SA, Pramanik A, Gopinatth V, Pelletier J, Sévigny J, Iqbal J, Jacobson KA

Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists

Journal Article

Bioorg Med Chem Lett, 75 , 2022.

Abstract | Links:

Schäkel L, Mirza S, Winzer R, Lopez V, Idris R, Al-Hroub H, Pelletier J, Sévigny J, Tolosa E, Müller CE

Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 - a promising target for cancer immunotherapy

Journal Article

J Immunother Cancer, 10 (8), 2022.

Abstract | Links:

Ullah S, Pelletier J, Sévigny J, Iqbal J

Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors

Journal Article

ACS Omega, 7 (30), 2022.

Abstract | Links:

286 entries « ‹ 1 of 29 › »
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Active projects

  • A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, from 2018-04-01 to 2023-03-31
  • A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease, from 2021-10-01 to 2026-09-30
  • Novel P2Y6 antagonists as a potential therapy for inflammatory bowel disease, from 2021-07-01 to 2024-06-30

Recently finished projects

  • Profil moléculaire sanguin de patientes souffrant de lupus, from 2019-04-01 to 2021-03-31
  • Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction., from 2016-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery