The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface. Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases. His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.
Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.
2705, boulevard Laurier
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Canada G1V 4G2
Latest news
- Une subvention de recherche de Crohn et Colite Canada pour Jean Sévigny 2021-10-25
- Près de 9,4 millions de subventions des IRSC pour les projets de 14 chercheurs du CRCHU 2021-08-03
- Maladies inflammatoires de l’intestin : un nouveau mécanisme protecteur découvert par une équipe du Centre de recherche du CHU de Québec-Université Laval 2021-02-17
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Canada G1V 4G2
Exploring chromone sulfonamides and sulfonylhydrazones as highly selective ectonucleotidase inhibitors: Synthesis, biological evaluation and in silico study
Journal ArticleBioorg Chem, 134 , 2023.
UTP increases wound healing in the self assembled skin substitute (SASS)
Journal ArticleJ Cell Commun Signal, 2023.
Epidermal melanocytes metabolize extracellular nucleotides by purinergic enzymes
Journal ArticleBiochem Cell Biol, 2023.
Design and synthesis of new adamantyl derivatives as promising antiproliferative agents
Journal ArticleEur J Med Chem, 246 , 2023.
Leishmania infantum NTPDase1 and NTPDase2 play an important role in infection and nitric oxide production in macrophages
Journal ArticleActa Trop, 237 , 2023.
Bioscaffold developed with decellularized human amniotic membrane seeded with mesenchymal stromal cells: assessment of efficacy and safety profiles in a second-degree burn preclinical model
Journal ArticleBiofabrication, 15 (1), 2022.
Identification of thienopyrimidine glycinates as selective inhibitors for h-NTPDases
Journal ArticleBioorg Chem, 129 , 2022.
Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists
Journal ArticleBioorg Med Chem Lett, 75 , 2022.
Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 - a promising target for cancer immunotherapy
Journal ArticleJ Immunother Cancer, 10 (8), 2022.
Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors
Journal ArticleACS Omega, 7 (30), 2022.
Active projects
- A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, from 2018-04-01 to 2023-03-31
- A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease, from 2021-10-01 to 2026-09-30
- Novel P2Y6 antagonists as a potential therapy for inflammatory bowel disease, from 2021-07-01 to 2024-06-30
Recently finished projects
- Profil moléculaire sanguin de patientes souffrant de lupus, from 2019-04-01 to 2021-03-31
- Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction., from 2016-04-01 to 2022-03-31