The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface.  Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases.  His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.

Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.

CHUL
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
299 entries « 1 of 30 »

Babou Kammoe RB, Sévigny J

Extracellular nucleotides in smooth muscle contraction

Journal Article

Biochem Pharmacol, 220 , 2024.

Abstract | Links:

Tasleem M, Pelletier J, Sévigny J, Hussain Z, Ajmal M, Al-Harrasi A, El-Kott AF, Taslimi P, Negm S, Shafiq Z, Iqbal J

Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors

Journal Article

Int J Biol Macromol, 266 (Pt 2), 2024.

Abstract | Links:

Huang X, Gu W, Zhang J, Lan Y, Colarusso JL, Li S, Pertl C, Lu J, Kim H, Zhu J, Breault DT, Sévigny J, Zhou Q

Stomach-derived human insulin-secreting organoids restore glucose homeostasis

Journal Article

Nat Cell Biol, 25 (5), 2023.

Abstract | Links:

da Silva W, Ribeiro IC, Agripino JM, da Silva VHF, de Souza LÂ, Oliveira TA, Bressan GC, Vasconcellos RS, Dumas C, Pelletier J, Sévigny J, Papadopoulou B, Fietto JLR

Leishmania infantum NTPDase1 and NTPDase2 play an important role in infection and nitric oxide production in macrophages

Journal Article

Acta Trop, 237 , 2023.

Abstract | Links:

Noronha-Matos JB, Pinto-Cardoso R, Bessa-Andrês C, Magalhães-Cardoso MT, Ferreirinha F, Costa MA, Marinhas J, Freitas R, Lemos R, Vilaça A, Oliveira A, Pelletier J, Sévigny J, Correia-de-Sá P

Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors

Journal Article

Stem Cell Res Ther, 14 (1), 2023.

Abstract | Links:

Bi C, Schäkel L, Mirza S, Sylvester K, Pelletier J, Lee SY, Pillaiyar T, Sévigny J, Müller CE

Synthesis and structure-activity relationships of ticlopidine derivatives and analogs as inhibitors of ectonucleotidase CD39

Journal Article

Bioorg Chem, 135 , 2023.

Abstract | Links:

Naasani LIS, Azevedo JG, Sévigny J, Franco de Oliveira T, Maria-Engler SS, Wink MR

Epidermal melanocytes metabolize extracellular nucleotides by purinergic enzymes

Journal Article

Biochem Cell Biol, 101 (3), 2023.

Abstract | Links:

Shahin AI, Zaraei SO, AlKubaisi BO, Ullah S, Anbar HS, El-Gamal R, Menon V, Abdel-Maksoud MS, Oh CH, El-Awady R, Gelsleichter NE, Pelletier J, Sévigny J, Iqbal J, Al-Tel TH, El-Gamal MI

Design and synthesis of new adamantyl derivatives as promising antiproliferative agents

Journal Article

Eur J Med Chem, 246 , 2023.

Abstract | Links:

Younus HA, Saeed M, Mahmood A, Jadoon MSK, Hameed A, Asari A, Mohamad H, Pelletier J, Sévigny J, Iqbal J, Al-Rashida M

Exploring chromone sulfonamides and sulfonylhydrazones as highly selective ectonucleotidase inhibitors: Synthesis, biological evaluation and in silico study

Journal Article

Bioorg Chem, 134 , 2023.

Abstract | Links:

Naasani LIS, Sévigny J, Moulin VJ, Wink MR

UTP increases wound healing in the self assembled skin substitute (SASS)

Journal Article

J Cell Commun Signal, 17 (3), 2023.

Abstract | Links:

299 entries « 1 of 30 »
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Active projects

  • A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease, from 2021-10-01 to 2026-09-30
  • Ectonucleotidases and Extracellular Nucleotides in Smooth Muscle Cell Contraction, from 2023-04-01 to 2028-03-31
  • Novel P2Y6 antagonists as a potential therapy for inflammatory bowel disease, from 2021-07-01 to 2025-06-30

Recently finished projects

  • A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, from 2018-04-01 to 2023-03-31
  • Scaling up the production of recombinant human NTPDase8 in CHO expression system for in vivo testing, from 2023-09-01 to 2024-03-31
Data provided by the Université Laval research projects registery