The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface.  Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases.  His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.

Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.

CHUL
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
263 entries « 1 of 27 »

Alvarez CL, Chêne A, Semblat JP, Gamain B, Lapouméroulie C, Fader CM, Hattab C, Sévigny J, Denis MFL, Lauri N, Ostuni MA, Schwarzbaum PJ

Homeostasis of extracellular ATP in uninfected RBCs from a Plasmodium falciparum culture and derived microparticles

Journal Article

Biochim Biophys Acta Biomembr, 2022.

Abstract | Links:

Hamoudi C, Zhao C, Abderrazak A, Salem M, Fortin PR, Sévigny J, Aoudjit F

The Purinergic Receptor P2X4 Promotes Th17 Activation and the Development of Arthritis

Journal Article

J Immunol, 208 (5), 2022.

Abstract | Links:

Abbas S, Afzal S, Nadeem H, Hussain D, Langer P, Sévigny J, Ashraf Z, Iqbal J

Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitors

Journal Article

Bioorg Chem, 118 , 2022.

Abstract | Links:

Salem M, Lecka J, Pelletier J, Gomes Marconato D, Dumas A, Vallières L, Brochu G, Robaye B, Jobin C, Sévigny J

NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD

Journal Article

Gut, 71 (1), 2022.

Abstract | Links:

Schäkel L, Mirza S, Pietsch M, Lee SY, Keuler T, Sylvester K, Pelletier J, Sévigny J, Pillaiyar T, Namasivayam V, Gütschow M, Müller CE

2-Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors

Journal Article

Arch Pharm (Weinheim), 354 (12), 2021.

Abstract | Links:

Iqbal J, Jacob C, Sévigny J

Editorial: Metalloenzymes: Potential Drug Targets

Journal Article

Front Pharmacol, 12 , 2021.

| Links:

Haas CB, Lovászi M, Pacher P, de Souza PO, Pelletier J, Leite RO, Sévigny J, Németh Z, Braganhol E, Haskó G

Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammation

Journal Article

Purinergic Signal, 17 (4), 2021.

Abstract | Links:

Murtaza A, Afzal S, Zaman G, Saeed A, Pelletier J, Sévigny J, Iqbal J, Hassan A

Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitor

Journal Article

Bioorg Chem, 115 , 2021.

Abstract | Links:

Dias AF, Scholl JN, Moritz CEJ, Kagami LP, das Neves GM, Eifler-Lima VL, Cruz-López O, Conejo-García A, Sévigny J, Battastini AMO, Campos JM, Figueiró F

New insights into cytotoxic mechanisms of bozepinib against glioblastoma

Journal Article

Eur J Pharm Sci, 162 , 2021.

Abstract | Links:

Schachter J, Alvarez CL, Bazzi Z, Faillace MP, Corradi G, Hattab C, Rinaldi DE, Gonzalez-Lebrero R, Molineris MP, Sévigny J, Ostuni MA, Schwarzbaum PJ

Extracellular ATP hydrolysis in Caco-2 human intestinal cell line

Journal Article

Biochim Biophys Acta Biomembr, 1863 (10), 2021.

Abstract | Links:

263 entries « 1 of 27 »
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Active projects

  • A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, from 2018-04-01 to 2023-03-31
  • A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease, from 2021-10-01 to 2026-09-30
  • Novel P2Y6 antagonists as a potential therapy for inflammatory bowel disease, from 2021-07-01 to 2024-06-30

Recently finished projects

  • Profil moléculaire sanguin de patientes souffrant de lupus, from 2019-04-01 to 2021-03-31
  • Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction., from 2016-04-01 to 2022-03-31
  • Soluble NTPDase8 as a novel biological therapy for inflammatory bowel disease, from 2019-07-01 to 2020-06-30
Data provided by the Université Laval research projects registery