Dr. Lambert is a regular researcher at the CHU de Québec-Université Laval Research Center and an assistant professor at the Faculty of Medicine of l’Université Laval in the department of Molecular Medicine. Dr. Lambert’s work aims to decipher how epigenetic regulators are assembled into functional units at the level of chromatin and how they impact transcription in healthy and cancerous cells. To address these fundamental questions, Dr. Lambert employs a multidisciplinary approach that includes mass spectrometry-based proteomics, protein biochemistry and cancer biology. He was recently awarded a prestigious Scholarship for the Next Generation of Scientists from the Cancer Research Society to support him as he establishes his research program.

Characterization of bromodomain-containing proteins in hormone-responsive cancers

Bromodomain-containing proteins are epigenetic regulators involved in many facets of the transcription process. Recently, numerous bromodomain inhibitors have been developed enabling the modulation of their activity for therapeutic benefit. Dr. Lambert’s group is currently investigating the functions of bromodomain-containing proteins in the context of hormone-responsive breast cancers to define their physical interplay with hormone receptors. In addition, Dr. Lambert is defining how specific cancer contexts impinged on bromodomain-containing proteins function and whether they generate actionable vulnerabilities that can targeted with bromodomain inhibitors.

Development of innovative functional proteomics technologies

To enable functional studies of epigenetic regulators, Dr. Lambert’s group is developing and implementing novel proteomics technologies to enable the study of proteomes, protein-protein interactions and post-translational modifications from clinically relevant samples. A particular focus of Dr. Lambert’s efforts remains the study of protein complexes associated with chromatin allowing the elucidation of the mechanisms enabling the ordered recruitment of epigenetic regulators to particular genomic loci.

CHUL
2705, boulevard Laurier
R-4779
Québec, QC
Canada G1V 4G2
83 entries « 8 of 9 »

Lambert JP, Baetz K, Figeys D

Of proteins and DNA--proteomic role in the field of chromatin research

Journal Article

Mol Biosyst, 6 (1), 2010.

Abstract | Links:

Lambert JP, Fillingham J, Siahbazi M, Greenblatt J, Baetz K, Figeys D

Defining the budding yeast chromatin-associated interactome

Journal Article

Mol Syst Biol, 6 , 2010.

Abstract | Links:

Zhou H, Hou W, Lambert JP, Figeys D

New ammunition for the proteomic reactor: strong anion exchange beads and multiple enzymes enhance protein identification and sequence coverage

Journal Article

Anal Bioanal Chem, 397 (8), 2010.

Abstract | Links:

Lambert JP, Mitchell L, Rudner A, Baetz K, Figeys D

A novel proteomics approach for the discovery of chromatin-associated protein networks

Journal Article

Mol Cell Proteomics, 8 (4), 2009.

Abstract | Links:

Fillingham J, Kainth P, Lambert JP, van Bakel H, Tsui K, Pena-Castillo L, Nislow C, Figeys D, Hughes TR, Greenblatt J, Andrews BJ

Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression

Journal Article

Mol Cell, 35 (3), 2009.

Abstract | Links:

Abu-Farha M, Lambert JP, Al-Madhoun AS, Elisma F, Skerjanc IS, Figeys D

The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase

Journal Article

Mol Cell Proteomics, 7 (3), 2008.

Abstract | Links:

Mitchell L, Lambert JP, Gerdes M, Al-Madhoun AS, Skerjanc IS, Figeys D, Baetz K

Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity

Journal Article

Mol Cell Biol, 28 (7), 2008.

Abstract | Links:

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D

Large-scale mapping of human protein-protein interactions by mass spectrometry

Journal Article

Mol Syst Biol, 3 , 2007.

Abstract | Links:

Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D

Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry

Journal Article

Proteomics, 7 (6), 2007.

Abstract | Links:

Smith JC, Lambert JP, Elisma F, Figeys D

Proteomics in 2005/2006: developments, applications and challenges

Journal Article

Anal Chem, 79 (12), 2007.

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83 entries « 8 of 9 »
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Active projects

  • Characterization of the scaffolding roles of bromodomain containing proteins at the level of chromatin, from 2017-04-01 to 2024-03-31
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada, from 2021-06-01 to 2024-05-31
  • Elucidation of bromodomain functions within SWI/SNF complexes, from 2020-04-01 to 2025-03-31
  • Étude des interactions bromodomain-dépendantes et de leurs impacts sur le cycle de transcription, from 2022-07-01 to 2026-06-30
  • Mitochondria bound to lipid droplets as new regulators of insulin resistance, from 2022-12-01 to 2025-11-30
  • Structural characterization of full-length BET proteins and their functional implications to cancer, from 2022-09-01 to 2024-08-31
  • TBC1D9: therapeutic target of the aggressiveness of triple negative breast cancer, from 2023-03-01 to 2024-02-29
  • Tetrahymena thermophila - un model évolutionnaire divergent pour découvrir de nouveau modes de régulation transcriptionnelle, from 2022-03-15 to 2025-03-14

Recently finished projects

  • Caractérisation du protéome mitochondrial de la prostate, from 2022-09-21 to 2023-03-31
  • Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer, from 2018-07-01 to 2022-06-30
  • Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer, from 2018-07-01 to 2022-06-30
  • COVID19 persistent symptomatology: an investigation of the metabolomic and proteomic underpinning, from 2021-06-01 to 2022-05-31
  • Investigating TBC1D9 therapeutic potential for triple negative breast cancer, from 2022-09-21 to 2023-03-31
  • Predict to prevent: Advanced proteomics profiling for precision medicine, from 2021-03-23 to 2022-09-30
  • Using BET bromodomain inhibitors to create phenotypic lethality in melanoma, from 2020-09-01 to 2022-08-31
Data provided by the Université Laval research projects registery