Dr. Lambert is a regular researcher at the CHU de Québec-Université Laval Research Center and an assistant professor at the Faculty of Medicine of l’Université Laval in the department of Molecular Medicine. Dr. Lambert’s work aims to decipher how epigenetic regulators are assembled into functional units at the level of chromatin and how they impact transcription in healthy and cancerous cells. To address these fundamental questions, Dr. Lambert employs a multidisciplinary approach that includes mass spectrometry-based proteomics, protein biochemistry and cancer biology. He was recently awarded a prestigious Scholarship for the Next Generation of Scientists from the Cancer Research Society to support him as he establishes his research program.

Characterization of bromodomain-containing proteins in hormone-responsive cancers

Bromodomain-containing proteins are epigenetic regulators involved in many facets of the transcription process. Recently, numerous bromodomain inhibitors have been developed enabling the modulation of their activity for therapeutic benefit. Dr. Lambert’s group is currently investigating the functions of bromodomain-containing proteins in the context of hormone-responsive breast cancers to define their physical interplay with hormone receptors. In addition, Dr. Lambert is defining how specific cancer contexts impinged on bromodomain-containing proteins function and whether they generate actionable vulnerabilities that can targeted with bromodomain inhibitors.

Development of innovative functional proteomics technologies

To enable functional studies of epigenetic regulators, Dr. Lambert’s group is developing and implementing novel proteomics technologies to enable the study of proteomes, protein-protein interactions and post-translational modifications from clinically relevant samples. A particular focus of Dr. Lambert’s efforts remains the study of protein complexes associated with chromatin allowing the elucidation of the mechanisms enabling the ordered recruitment of epigenetic regulators to particular genomic loci.

CHUL
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78 entries « 2 of 8 »

Bilodeau S, Kurat CF, Lambert JP

Editorial: The Evolving Chromatin and Transcriptional Landscapes-Emerging Methods, Tools and Techniques

Journal Article

Front Cell Dev Biol, 9 , 2021.

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M Gagné L, Morin N, Lavoie N, Bisson N, Lambert JP, Mallette FA, Huot MÉ

Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling

Journal Article

J Biol Chem, 297 (5), 2021.

Abstract | Links:

Nabeel-Shah S, Garg J, Kougnassoukou Tchara PE, Pearlman RE, Lambert JP, Fillingham J

Functional proteomics protocol for the identification of interaction partners in Tetrahymena thermophila

Journal Article

STAR Protoc, 2 (1), 2021.

Abstract | Links:

Dionne U, Bourgault E, Dube AK, Bradley D, Chartier FJM, Dandage R, Dibyachintan S, Despres PC, Gish GD, Pham NTH, Letourneau M, Lambert JP, Doucet N, Bisson N, Landry CR

Protein context shapes the specificity of SH3 domain-mediated interactions in vivo

Journal Article

Nat Commun, 12 (1), 2021.

Abstract | Links:

Nabeel-Shah S, Garg J, Saettone A, Ashraf K, Lee H, Wahab S, Ahmed N, Fine J, Derynck J, Pu S, Ponce M, Marcon E, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J

Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila

Journal Article

Nucleic Acids Res, 49 (11), 2021.

Abstract | Links:

Go CD, Knight JDR, Rajasekharan A, Rathod B, Hesketh GG, Abe KT, Youn JY, Samavarchi-Tehrani P, Zhang H, Zhu LY, Popiel E, Lambert JP, Coyaud É, Cheung SWT, Rajendran D, Wong CJ, Antonicka H, Pelletier L, Palazzo AF, Shoubridge EA, Raught B, Gingras AC

A proximity-dependent biotinylation map of a human cell

Journal Article

Nature, 595 (7865), 2021.

Abstract | Links:

Kothari C, Osseni MA, Agbo L, Ouellette G, Deraspe M, Laviolette F, Corbeil J, Lambert JP, Diorio C, Durocher F

Machine learning analysis identifies genes differentiating triple negative breast cancers

Journal Article

Sci Rep, 10 (1), 2020.

Abstract | Links:

Nabeel-Shah S, Ashraf K, Saettone A, Garg J, Derynck J, Lambert JP, Pearlman RE, Fillingham J

Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila

Journal Article

Sci Rep, 10 (1), 2020.

Abstract | Links:

Fages J, Chailleux C, Humbert J, Jang SM, Loehr J, Lambert JP, Cote J, Trouche D, Canitrot Y

JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage

Journal Article

PLoS Genet, 16 (6), 2020.

Abstract | Links:

Louphrasitthiphol P, Siddaway R, Loffreda A, Pogenberg V, Friedrichsen H, Schepsky A, Zeng Z, Lu M, Strub T, Freter R, Lisle R, Suer E, Thomas B, Schuster-Böckler B, Filippakopoulos P, Middleton M, Lu X, Patton EE, Davidson I, Lambert JP, Wilmanns M, Steingrímsson E, Mazza D, Goding CR

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

Journal Article

Mol Cell, 79 (3), 2020.

Abstract | Links:

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Active projects

  • Caractérisation du protéome mitochondrial de la prostate, from 2022-09-21 to 2023-03-31
  • Characterization of the scaffolding roles of bromodomain containing proteins at the level of chromatin, from 2017-04-01 to 2024-03-31
  • Elucidation of bromodomain functions within SWI/SNF complexes, from 2020-04-01 to 2025-03-31
  • Étude des interactions bromodomain-dépendantes et de leurs impacts sur le cycle de transcription, from 2022-07-01 to 2026-06-30
  • Investigating TBC1D9 therapeutic potential for triple negative breast cancer, from 2022-09-21 to 2023-03-31
  • Structural characterization of full-length BET proteins and their functional implications to cancer, from 2022-09-01 to 2024-08-31
  • Tetrahymena thermophila - un model évolutionnaire divergent pour découvrir de nouveau modes de régulation transcriptionnelle, from 2022-03-15 to 2025-03-14

Recently finished projects

  • Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer, from 2018-07-01 to 2022-06-30
  • Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer, from 2018-07-01 to 2022-06-30
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada, from 2021-06-01 to 2022-05-31
  • COVID19 persistent symptomatology: an investigation of the metabolomic and proteomic underpinning, from 2021-06-01 to 2022-05-31
  • Elucidation of bromodomain functions within SWI/SNF complexes (Prix), from 2020-03-01 to 2021-02-28
  • Establishment of an infrastructure for functional proteomics studies of cancer, from 2018-09-01 to 2021-06-30
  • Predict to prevent: Advanced proteomics profiling for precision medicine, from 2021-03-23 to 2022-09-30
  • Using BET bromodomain inhibitors to create phenotypic lethality in melanoma, from 2020-09-01 to 2022-08-31
Data provided by the Université Laval research projects registery