Dr. Lambert is a regular researcher at the CHU de Québec-Université Laval Research Center and an assistant professor at the Faculty of Medicine of l’Université Laval in the department of Molecular Medicine. Dr. Lambert’s work aims to decipher how epigenetic regulators are assembled into functional units at the level of chromatin and how they impact transcription in healthy and cancerous cells. To address these fundamental questions, Dr. Lambert employs a multidisciplinary approach that includes mass spectrometry-based proteomics, protein biochemistry and cancer biology. He was recently awarded a prestigious Scholarship for the Next Generation of Scientists from the Cancer Research Society to support him as he establishes his research program.
Characterization of bromodomain-containing proteins in hormone-responsive cancers
Bromodomain-containing proteins are epigenetic regulators involved in many facets of the transcription process. Recently, numerous bromodomain inhibitors have been developed enabling the modulation of their activity for therapeutic benefit. Dr. Lambert’s group is currently investigating the functions of bromodomain-containing proteins in the context of hormone-responsive breast cancers to define their physical interplay with hormone receptors. In addition, Dr. Lambert is defining how specific cancer contexts impinged on bromodomain-containing proteins function and whether they generate actionable vulnerabilities that can targeted with bromodomain inhibitors.
Development of innovative functional proteomics technologies
To enable functional studies of epigenetic regulators, Dr. Lambert’s group is developing and implementing novel proteomics technologies to enable the study of proteomes, protein-protein interactions and post-translational modifications from clinically relevant samples. A particular focus of Dr. Lambert’s efforts remains the study of protein complexes associated with chromatin allowing the elucidation of the mechanisms enabling the ordered recruitment of epigenetic regulators to particular genomic loci.
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Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer
Journal ArticleMol Oncol, 2023.
Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation
Journal ArticleEpigenetics Chromatin, 16 (1), 2023.
Characterization of the Functional Interplay between the BRD7 and BRD9 Homologues in mSWI/SNF Complexes
Journal ArticleJ Proteome Res, 22 (1), 2023.
Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation
Journal ArticleNAR Cancer, 4 (4), 2022.
EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks
Journal ArticleCell Rep, 40 (1), 2022.
The MITF regulatory network in melanoma
Journal ArticlePigment Cell Melanoma Res, 35 (5), 2022.
Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci
Journal ArticleGenes Dev, 36 (11-12), 2022.
MRG Proteins Are Shared by Multiple Protein Complexes With Distinct Functions
Journal ArticleMol Cell Proteomics, 21 (7), 2022.
Comprehensive Interactome Mapping of Nuclear Receptors Using Proximity Biotinylation
Journal ArticleMethods Mol Biol, 2456 , 2022.
A Nutrient-Based Cellular Model to Characterize Acetylation-Dependent Protein-Protein Interactions
Journal ArticleFront Mol Biosci, 9 , 2022.
Active projects
- Characterization of the scaffolding roles of bromodomain containing proteins at the level of chromatin, from 2017-04-01 to 2024-03-31
- Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada, from 2021-06-01 to 2024-05-31
- Elucidation of bromodomain functions within SWI/SNF complexes, from 2020-04-01 to 2025-03-31
- Étude des interactions bromodomain-dépendantes et de leurs impacts sur le cycle de transcription, from 2022-07-01 to 2026-06-30
- Mitochondria bound to lipid droplets as new regulators of insulin resistance, from 2022-12-01 to 2025-11-30
- Structural characterization of full-length BET proteins and their functional implications to cancer, from 2022-09-01 to 2024-08-31
- TBC1D9: therapeutic target of the aggressiveness of triple negative breast cancer, from 2023-03-01 to 2024-02-29
- Tetrahymena thermophila - un model évolutionnaire divergent pour découvrir de nouveau modes de régulation transcriptionnelle, from 2022-03-15 to 2025-03-14
Recently finished projects
- Caractérisation du protéome mitochondrial de la prostate, from 2022-09-21 to 2023-03-31
- Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer, from 2018-07-01 to 2022-06-30
- Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer, from 2018-07-01 to 2022-06-30
- COVID19 persistent symptomatology: an investigation of the metabolomic and proteomic underpinning, from 2021-06-01 to 2022-05-31
- Investigating TBC1D9 therapeutic potential for triple negative breast cancer, from 2022-09-21 to 2023-03-31
- Predict to prevent: Advanced proteomics profiling for precision medicine, from 2021-03-23 to 2022-09-30
- Using BET bromodomain inhibitors to create phenotypic lethality in melanoma, from 2020-09-01 to 2022-08-31