Dr. Jean-François Bilodeau, PhD, is a professor in the Laval University School of Medicine’s Department of Medicine and a regular researcher at the CHU of Quebec-Laval University Research Center. His research focuses on the physiological and pathological roles of oxidative stress, at the cellular and tissue levels.
Early detection of hypertension in pregnancy
Hypertensive disorders complicate 5-8% of all pregnancies. Hypertension with proteinuria (preeclampsia) is a complex pathology of the second half of pregnancy, with an estimated prevalence of 3%. Preeclampsia is a major health concern for the newborn and the mother, as it can lead to premature births associated with high perinatal mortality. Currently, there is no effective treatment against it, except for induced childbirth. Our recent work showed that the imbalance between antioxidants and reactive oxygen species (oxidative stress) plays a major role. In addition, this oxidative stress can alter the biosynthesis of bioactive lipids affecting vascular tone (hypertension) and inflammatory response. Our research objectives are to understand the physiopathology in relation to oxidative stress, and to develop a method of early detection of this syndrome.
Targeted lipidomics of oxidized derivatives of polyunsaturated fatty acids
Our laboratory has developed a unique expertise in the determination of hundreds of isomers of oxidized polyunsaturated fatty acids, by mass spectrometry. Omega-3 and omega-6 fatty acids are susceptible to oxidation, and are also the substrate for the eicosanoids involved in inflammation and vascular tone control. Specifically, we use LC-MS /MS and GC /MS methodology, in addition to other complementary methodologies derived from transcriptomics and proteomics.
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2
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- Greffard, KarineEmployeeCHUL+1 418-525-4444, extension 48181 / 42296Karine.Greffard@crchudequebec.ulaval.ca
2705, boulevard Laurier
T4-50
Québec, Québec
Canada G1V 4G2
Physical fitness is associated with prostaglandin F isomers during pregnancy
Journal ArticleProstaglandins Leukot Essent Fatty Acids, 145 , 2019.
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F-isoprostanes and fatty acids profile in early pregnancy complicated by pre-existing diabetes
Journal ArticleProstaglandins Leukot Essent Fatty Acids, 135 , 2018.
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Modulation of the biomarkers of inflammation and oxidative stress by ruminant trans fatty acids and dairy proteins in vascular endothelial cells (HUVEC)
Journal ArticleProstaglandins Leukot Essent Fatty Acids, 126 , 2017.
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Increased placental phospholipase A gene expression and free F-isoprostane levels in response to oxidative stress in preeclampsia
Journal ArticlePlacenta, 55 , 2017.
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Placental dimethyl acetal fatty acid derivatives are elevated in preeclampsia
Journal ArticlePlacenta, 51 , 2017.
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Alterations of fatty acid profiles in gestational diabetes and influence of the diet
Journal ArticleMaturitas, 99 , 2017.
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Trans Fatty Acids Suppress TNF-α-Induced Inflammatory Gene Expression in Endothelial (HUVEC) and Hepatocellular Carcinoma (HepG2) Cells
Journal ArticleLipids, 52 (4), 2017.
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Dietary fats and F-isoprostanes: A review of the clinical evidence
Journal ArticleCrit Rev Food Sci Nutr, 57 (18), 2017.
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Perinatal Oxidative Stress May Affect Fetal Ghrelin Levels in Humans
Journal ArticleSci Rep, 5 , 2015.
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Plasma F2-isoprostane class VI isomers at 12-18 weeks of pregnancy are associated with later occurrence of preeclampsia
Journal ArticleFree Radic Biol Med, 85 , 2015.
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Recently finished projects
- Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, from 2017-04-01 to 2022-03-31