Dr. Jean-François Bilodeau, PhD, is a professor in the Laval University School of Medicine’s Department of Medicine and a regular researcher at the CHU of Quebec-Laval University Research Center. His research focuses on the physiological and pathological roles of oxidative stress, at the cellular and tissue levels.
Early detection of hypertension in pregnancy
Hypertensive disorders complicate 5-8% of all pregnancies. Hypertension with proteinuria (preeclampsia) is a complex pathology of the second half of pregnancy, with an estimated prevalence of 3%. Preeclampsia is a major health concern for the newborn and the mother, as it can lead to premature births associated with high perinatal mortality. Currently, there is no effective treatment against it, except for induced childbirth. Our recent work showed that the imbalance between antioxidants and reactive oxygen species (oxidative stress) plays a major role. In addition, this oxidative stress can alter the biosynthesis of bioactive lipids affecting vascular tone (hypertension) and inflammatory response. Our research objectives are to understand the physiopathology in relation to oxidative stress, and to develop a method of early detection of this syndrome.
Targeted lipidomics of oxidized derivatives of polyunsaturated fatty acids
Our laboratory has developed a unique expertise in the determination of hundreds of isomers of oxidized polyunsaturated fatty acids, by mass spectrometry. Omega-3 and omega-6 fatty acids are susceptible to oxidation, and are also the substrate for the eicosanoids involved in inflammation and vascular tone control. Specifically, we use LC-MS /MS and GC /MS methodology, in addition to other complementary methodologies derived from transcriptomics and proteomics.
2705, boulevard Laurier
Canada G1V 4G2
Data not available
Remodeling of lipid landscape in high fat fed very-long chain acyl-CoA dehydrogenase null mice favors pro-arrhythmic polyunsaturated fatty acids and their downstream metabolitesJournal Article
Biochim Biophys Acta Mol Basis Dis, 1869 (8), 2023.
Docosahexaenoic acid-rich algae oil supplementation in mothers of preterm infants is associated with a modification in breast milk oxylipins profileJournal Article
Lipids Health Dis, 22 (1), 2023.
Industrial and Ruminant Trans-Fatty Acids-Enriched Diets Differentially Modulate the Microbiome and Fecal Metabolites in C57BL/6 MiceJournal Article
Nutrients, 15 (6), 2023.
Marginal Impact of Brown Seaweed Ascophyllum nodosum and Fucus vesiculosus Extract on Metabolic and Inflammatory Response in Overweight and Obese Prediabetic SubjectsJournal Article
Mar Drugs, 20 (3), 2022.
Docosahexaenoic acid-rich algae oil supplementation on breast milk fatty acid profile of mothers who delivered prematurely: a randomized clinical trialJournal Article
Sci Rep, 11 (1), 2021.
Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophyJournal Article
Nat Commun, 12 (1), 2021.
Impact of Dairy Intake on Plasma F-IsoProstane Profiles in Overweight Subjects with Hyperinsulinemia: A Randomized Crossover TrialJournal Article
Nutrients, 13 (6), 2021.
The plasma antioxidant vitamin status of the INTAPP cohort examined: The unsuspected importance of β-carotene and γ-tocopherol in preeclampsiaJournal Article
Pregnancy Hypertens, 25 , 2021.
Long chain omega-3 fatty acids and their oxidized metabolites are associated with reduced prostate tumor growthJournal Article
Prostaglandins Leukot Essent Fatty Acids, 164 , 2021.
Maternal vitamin D, oxidative stress, and pre-eclampsiaJournal Article
Int J Gynaecol Obstet, 154 (3), 2021.
Recently finished projects
- Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, from 2017-04-01 to 2022-03-31