Dr. Jean-François Bilodeau, PhD, is a professor in the Laval University School of Medicine’s Department of Medicine and a regular researcher at the CHU of Quebec-Laval University Research Center. His research focuses on the physiological and pathological roles of oxidative stress, at the cellular and tissue levels.

Early detection of hypertension in pregnancy

Hypertensive disorders complicate 5-8% of all pregnancies. Hypertension with proteinuria (preeclampsia) is a complex pathology of the second half of pregnancy, with an estimated prevalence of 3%. Preeclampsia is a major health concern for the newborn and the mother, as it can lead to premature births associated with high perinatal mortality. Currently, there is no effective treatment against it, except for induced childbirth. Our recent work showed that the imbalance between antioxidants and reactive oxygen species (oxidative stress) plays a major role. In addition, this oxidative stress can alter the biosynthesis of bioactive lipids affecting vascular tone (hypertension) and inflammatory response. Our research objectives are to understand the physiopathology in relation to oxidative stress, and to develop a method of early detection of this syndrome.

Targeted lipidomics of oxidized derivatives of polyunsaturated fatty acids

Our laboratory has developed a unique expertise in the determination of hundreds of isomers of oxidized polyunsaturated fatty acids, by mass spectrometry. Omega-3 and omega-6 fatty acids are susceptible to oxidation, and are also the substrate for the eicosanoids involved in inflammation and vascular tone control. Specifically, we use LC-MS /MS and GC /MS methodology, in addition to other complementary methodologies derived from transcriptomics and proteomics.

CHUL
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46153
+1 418-654-2783
Jean-Francois.Bilodeau@cr...

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Vodouhè M, Marois J, Guay V, Leblanc N, Weisnagel SJ, Bilodeau JF, Jacques H

Marginal Impact of Brown Seaweed Ascophyllum nodosum and Fucus vesiculosus Extract on Metabolic and Inflammatory Response in Overweight and Obese Prediabetic Subjects

Journal Article

Mar Drugs, 20 (3), 2022.

Abstract | Links:

Fougère H, Bilodeau JF, Lavoie PM, Mohamed I, Rudkowska I, Pronovost E, Simonyan D, Berthiaume L, Guillot M, Piedboeuf B, Julien P, Marc I

Docosahexaenoic acid-rich algae oil supplementation on breast milk fatty acid profile of mothers who delivered prematurely: a randomized clinical trial

Journal Article

Sci Rep, 11 (1), 2021.

Abstract | Links:

Dort J, Orfi Z, Fabre P, Molina T, Conte TC, Greffard K, Pellerito O, Bilodeau JF, Dumont NA

Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy

Journal Article

Nat Commun, 12 (1), 2021.

Abstract | Links:

Khorraminezhad L, Bilodeau JF, Greffard K, Larose J, Rudkowska I

Impact of Dairy Intake on Plasma F-IsoProstane Profiles in Overweight Subjects with Hyperinsulinemia: A Randomized Crossover Trial

Journal Article

Nutrients, 13 (6), 2021.

Abstract | Links:

Bilodeau JF, Gagné A, Greffard K, Audibert F, Fraser WD, Julien P

The plasma antioxidant vitamin status of the INTAPP cohort examined: The unsuspected importance of β-carotene and γ-tocopherol in preeclampsia

Journal Article

Pregnancy Hypertens, 25 , 2021.

Abstract | Links:

Bilodeau JF, Gevariya N, Larose J, Robitaille K, Roy J, Oger C, Galano JM, Bergeron A, Durand T, Fradet Y, Julien P, Fradet V

Long chain omega-3 fatty acids and their oxidized metabolites are associated with reduced prostate tumor growth

Journal Article

Prostaglandins Leukot Essent Fatty Acids, 164 , 2021.

Abstract | Links:

Wei SQ, Bilodeau JF, Julien P, Luo ZC, Abenhaim HA, Bi WG, Nuyt AM, Leduc L, Audibert F, Fraser WD

Maternal vitamin D, oxidative stress, and pre-eclampsia

Journal Article

Int J Gynaecol Obstet, 154 (3), 2021.

Abstract | Links:

Khorraminezhad L, Leclercq M, Droit A, Bilodeau JF, Rudkowska I

Statistical and Machine-Learning Analyses in Nutritional Genomics Studies

Journal Article

Nutrients, 12 (10), 2020.

Abstract | Links:

O'Connor S, Greffard K, Leclercq M, Julien P, Weisnagel SJ, Gagnon C, Droit A, Bilodeau JF, Rudkowska I

Increased Dairy Product Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes

Journal Article

Mol Nutr Food Res, 63 (19), 2019.

Abstract | Links:

Bilodeau JF, Bisson M, Larose J, Pronovost E, Brien M, Greffard K, Marc I

Physical fitness is associated with prostaglandin F isomers during pregnancy

Journal Article

Prostaglandins Leukot Essent Fatty Acids, 145 , 2019.

Abstract | Links:

48 entries « ‹ 1 of 5 › »
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Recently finished projects

  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, from 2017-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery