Dr. Jean-François Bilodeau, PhD, is a professor in the Laval University School of Medicine’s Department of Medicine and a regular researcher at the CHU of Quebec-Laval University Research Center. His research focuses on the physiological and pathological roles of oxidative stress, at the cellular and tissue levels.
Early detection of hypertension in pregnancy
Hypertensive disorders complicate 5-8% of all pregnancies. Hypertension with proteinuria (preeclampsia) is a complex pathology of the second half of pregnancy, with an estimated prevalence of 3%. Preeclampsia is a major health concern for the newborn and the mother, as it can lead to premature births associated with high perinatal mortality. Currently, there is no effective treatment against it, except for induced childbirth. Our recent work showed that the imbalance between antioxidants and reactive oxygen species (oxidative stress) plays a major role. In addition, this oxidative stress can alter the biosynthesis of bioactive lipids affecting vascular tone (hypertension) and inflammatory response. Our research objectives are to understand the physiopathology in relation to oxidative stress, and to develop a method of early detection of this syndrome.
Targeted lipidomics of oxidized derivatives of polyunsaturated fatty acids
Our laboratory has developed a unique expertise in the determination of hundreds of isomers of oxidized polyunsaturated fatty acids, by mass spectrometry. Omega-3 and omega-6 fatty acids are susceptible to oxidation, and are also the substrate for the eicosanoids involved in inflammation and vascular tone control. Specifically, we use LC-MS /MS and GC /MS methodology, in addition to other complementary methodologies derived from transcriptomics and proteomics.
2705, boulevard Laurier
Canada G1V 4G2
Data not available
Marginal Impact of Brown Seaweed Ascophyllum nodosum and Fucus vesiculosus Extract on Metabolic and Inflammatory Response in Overweight and Obese Prediabetic SubjectsJournal Article
Mar Drugs, 20 (3), 2022.
Docosahexaenoic acid-rich algae oil supplementation on breast milk fatty acid profile of mothers who delivered prematurely: a randomized clinical trialJournal Article
Sci Rep, 11 (1), 2021.
Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophyJournal Article
Nat Commun, 12 (1), 2021.
Impact of Dairy Intake on Plasma F-IsoProstane Profiles in Overweight Subjects with Hyperinsulinemia: A Randomized Crossover TrialJournal Article
Nutrients, 13 (6), 2021.
The plasma antioxidant vitamin status of the INTAPP cohort examined: The unsuspected importance of β-carotene and γ-tocopherol in preeclampsiaJournal Article
Pregnancy Hypertens, 25 , 2021.
Long chain omega-3 fatty acids and their oxidized metabolites are associated with reduced prostate tumor growthJournal Article
Prostaglandins Leukot Essent Fatty Acids, 164 , 2021.
Maternal vitamin D, oxidative stress, and pre-eclampsiaJournal Article
Int J Gynaecol Obstet, 154 (3), 2021.
Statistical and Machine-Learning Analyses in Nutritional Genomics StudiesJournal Article
Nutrients, 12 (10), 2020.
Increased Dairy Product Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 DiabetesJournal Article
Mol Nutr Food Res, 63 (19), 2019.
Physical fitness is associated with prostaglandin F isomers during pregnancyJournal Article
Prostaglandins Leukot Essent Fatty Acids, 145 , 2019.
Recently finished projects
- Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, from 2017-04-01 to 2022-03-31