Dr. Jean-François Bilodeau, PhD, is a professor in the Laval University School of Medicine’s Department of Medicine and a regular researcher at the CHU of Quebec-Laval University Research Center. His research focuses on the physiological and pathological roles of oxidative stress, at the cellular and tissue levels.

Early detection of hypertension in pregnancy

Hypertensive disorders complicate 5-8% of all pregnancies. Hypertension with proteinuria (preeclampsia) is a complex pathology of the second half of pregnancy, with an estimated prevalence of 3%. Preeclampsia is a major health concern for the newborn and the mother, as it can lead to premature births associated with high perinatal mortality. Currently, there is no effective treatment against it, except for induced childbirth. Our recent work showed that the imbalance between antioxidants and reactive oxygen species (oxidative stress) plays a major role. In addition, this oxidative stress can alter the biosynthesis of bioactive lipids affecting vascular tone (hypertension) and inflammatory response. Our research objectives are to understand the physiopathology in relation to oxidative stress, and to develop a method of early detection of this syndrome.

Targeted lipidomics of oxidized derivatives of polyunsaturated fatty acids

Our laboratory has developed a unique expertise in the determination of hundreds of isomers of oxidized polyunsaturated fatty acids, by mass spectrometry. Omega-3 and omega-6 fatty acids are susceptible to oxidation, and are also the substrate for the eicosanoids involved in inflammation and vascular tone control. Specifically, we use LC-MS /MS and GC /MS methodology, in addition to other complementary methodologies derived from transcriptomics and proteomics.

CHUL
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2

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51 entries « 1 of 6 »

Fougère H, Greffard K, Guillot M, Rudkowska I, Pronovost E, Simonyan D, Marc I, Bilodeau JF

Docosahexaenoic acid-rich algae oil supplementation in mothers of preterm infants is associated with a modification in breast milk oxylipins profile

Journal Article

Lipids Health Dis, 22 (1), 2023.

Abstract | Links:

Mohammadi F, Green M, Tolsdorf E, Greffard K, Leclercq M, Bilodeau JF, Droit A, Foster J, Bertrand N, Rudkowska I

Industrial and Ruminant Trans-Fatty Acids-Enriched Diets Differentially Modulate the Microbiome and Fecal Metabolites in C57BL/6 Mice

Journal Article

Nutrients, 15 (6), 2023.

Abstract | Links:

Lefort B, Gélinas R, Forest A, Bouchard B, Daneault C, Robillard Frayne I, Roy J, Oger C, Greffard K, Galano JM, Durand T, Labarthe F, Bilodeau JF, Ruiz M, Des Rosiers C

Remodeling of lipid landscape in high fat fed very-long chain acyl-CoA dehydrogenase null mice favors pro-arrhythmic polyunsaturated fatty acids and their downstream metabolites

Journal Article

Biochim Biophys Acta Mol Basis Dis, 1869 (8), 2023.

Abstract | Links:

Vodouhè M, Marois J, Guay V, Leblanc N, Weisnagel SJ, Bilodeau JF, Jacques H

Marginal Impact of Brown Seaweed Ascophyllum nodosum and Fucus vesiculosus Extract on Metabolic and Inflammatory Response in Overweight and Obese Prediabetic Subjects

Journal Article

Mar Drugs, 20 (3), 2022.

Abstract | Links:

Wei SQ, Bilodeau JF, Julien P, Luo ZC, Abenhaim HA, Bi WG, Nuyt AM, Leduc L, Audibert F, Fraser WD

Maternal vitamin D, oxidative stress, and pre-eclampsia

Journal Article

Int J Gynaecol Obstet, 154 (3), 2021.

Abstract | Links:

Bilodeau JF, Gevariya N, Larose J, Robitaille K, Roy J, Oger C, Galano JM, Bergeron A, Durand T, Fradet Y, Julien P, Fradet V

Long chain omega-3 fatty acids and their oxidized metabolites are associated with reduced prostate tumor growth

Journal Article

Prostaglandins Leukot Essent Fatty Acids, 164 , 2021.

Abstract | Links:

Bilodeau JF, Gagné A, Greffard K, Audibert F, Fraser WD, Julien P

The plasma antioxidant vitamin status of the INTAPP cohort examined: The unsuspected importance of β-carotene and γ-tocopherol in preeclampsia

Journal Article

Pregnancy Hypertens, 25 , 2021.

Abstract | Links:

Dort J, Orfi Z, Fabre P, Molina T, Conte TC, Greffard K, Pellerito O, Bilodeau JF, Dumont NA

Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy

Journal Article

Nat Commun, 12 (1), 2021.

Abstract | Links:

Fougère H, Bilodeau JF, Lavoie PM, Mohamed I, Rudkowska I, Pronovost E, Simonyan D, Berthiaume L, Guillot M, Piedboeuf B, Julien P, Marc I

Docosahexaenoic acid-rich algae oil supplementation on breast milk fatty acid profile of mothers who delivered prematurely: a randomized clinical trial

Journal Article

Sci Rep, 11 (1), 2021.

Abstract | Links:

Khorraminezhad L, Bilodeau JF, Greffard K, Larose J, Rudkowska I

Impact of Dairy Intake on Plasma F-IsoProstane Profiles in Overweight Subjects with Hyperinsulinemia: A Randomized Crossover Trial

Journal Article

Nutrients, 13 (6), 2021.

Abstract | Links:

51 entries « 1 of 6 »
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Active projects

  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, from 2017-04-01 to 2025-03-31
Data provided by the Université Laval research projects registery