Dr.  Jean Charron is an investigator at the Research Centre of the CHU of Québec-Université Laval in the Oncology axis. He is also Professor at the Department of molecular biology, medical biochemistry and pathology in the Faculty of medicine at Université Laval. His research activities focus on the functional characterization of the decision-making mechanisms of the ERK/MAPK signaling pathway in cells when exposed to developmental or environmental cues. These mechanisms are essential for embryonic development and homeostasis of every living throughout life.  Any failure of interpretation of cell signalling leads to malformations or pathologies.

Role of the ERK/MAPK pathway in lung development

The development of the respiratory tract is complex and requires several steps of morphogenesis, differentiation and maturation to form the definitive lung. The integration of signals induces by the interaction of secreted factors with their receptors or by cell-cell interactions is essential for lung formation. Dr. Charron’s laboratory examines the role of the ERK/MAPK pathway in lung development using the mouse as a model.  His team has already highlighted the role of the ERK/MAPK pathway in lung morphogenesis during bronchial branching and the formation of tracheal cartilage. These defects faithfully recapitulate the phenotypes of significant and costly human diseases, including lung hypoplasia, lung agenesis and tracheomalacia, each representing a major public health concern. These studies will play an increasingly important role in providing insights into the molecular mechanisms underlying fetal and neonatal diseases and in allowing development of novel targeted therapies.

Role of the ERK/MAPK path in the development of autoimmune diseases

The work of the team of Dr. Charron has also shown that decreased ERK/MAPK signaling in hematopoietic cells causes the abnormal production of autoantibodies directed against nuclear proteins and DNA double strand in mice. Over time, these mice develop a glomerulonephritis leading to kidney failure and severe anemia. These symptoms are similar to those of systemic lupus erythematosus (SLE), a severe auto-immune disease more frequent in women than in men. In the murine model generated in the laboratory of Dr. Charron, the females are also 5 times more likely to develop the disease than males. Work is in progress in Dr. Charron’s laboratory to identify which immune cell types are involved in the onset of the auto-immune disease and which molecular mechanisms are involved. This study will provide understanding of the molecular processes leading to the development of autoimmune diseases, and will eventually lead to new therapeutic approaches adapted to sex.

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28 entries « 1 of 3 »

Houde N, Espéli M, Charron J

[Involvement of MEK1 and MEK2 kinases in the maturation of the mouse immune system]

Journal Article

Med Sci (Paris), 38 (6-7), 2022.

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Gong KQ, Mikacenic C, Long ME, Frevert CW, Birkland TP, Charron J, Gharib SA, Manicone AM

MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and Associates with Acute Respiratory Distress Syndrome Outcome

Journal Article

Am J Respir Cell Mol Biol, 66 (5), 2022.

Abstract | Links:

Houde N, Beuret L, Bonaud A, Fortier-Beaulieu SP, Truchon-Landry K, Aoidi R, Pic É, Alouche N, Rondeau V, Schlecht-Louf G, Balabanian K, Espéli M, Charron J

Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation

Journal Article

Cell Rep, 38 (2), 2022.

Abstract | Links:

Beuret L, Fortier-Beaulieu SP, Rondeau V, Roy S, Houde N, Balabanian K, Espéli M, Charron J

Mek1 and Mek2 Functional Redundancy in Erythropoiesis

Journal Article

Front Cell Dev Biol, 9 , 2021.

Abstract | Links:

Li K, Wu H, Wang A, Charron J, Mishina Y, Habib SL, Liu H, Li B

mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways

Journal Article

Cell Rep, 35 (5), 2021.

Abstract | Links:

Long ME, Gong KQ, Eddy WE, Volk JS, Morrell ED, Mikacenic C, West TE, Skerrett SJ, Charron J, Liles WC, Manicone AM

MEK1 regulates pulmonary macrophage inflammatory responses and resolution of acute lung injury

Journal Article

JCI Insight, 4 (23), 2019.

Abstract | Links:

Aoidi R, Houde N, Landry-Truchon K, Holter M, Jacquet K, Charron L, Krishnaswami SR, Yu BD, Rauen KA, Bisson N, Newbern J, Charron J

Mek1Y130C mice recapitulate aspects of human cardio-facio-cutaneous syndrome

Journal Article

Dis Model Mech, 11 (3), 2018.

Abstract | Links:

Aoidi R, Maltais A, Charron J

Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect

Journal Article

Sci Signal, 9 (412), 2016.

Abstract | Links:

Ihermann-Hella A, Lume M, Miinalainen IJ, Pirttiniemi A, Gui Y, Peranen J, Charron J, Saarma M, Costantini F, Kuure S

Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion

Journal Article

PLoS Genet, 10 (3), 2014.

Abstract | Links:

Whittington RA, Bretteville A, Virag L, Emala CW, Maurin TO, Marcouiller F, Julien C, Petry FR, El-Khoury NB, Morin F, Charron J, Planel E

Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation

Journal Article

Sci Rep, 3 , 2013.

Abstract | Links:

28 entries « 1 of 3 »
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Recently finished projects

  • Role of the ERK/MAPK pathway in intestine development and homeostasis., from 2016-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery