Jacques Côté obtained his PhD from Laval University after he characterized the structure and function of Endo G, an endonuclease involved in the replication of mitochondrial DNA and cell apoptosis. He did post-doctoral training with Dr. Jerry Workman at Penn State University where he identified and characterized chromatin remodeling complexes (SWI/SNF) involved in gene activation. In 1997, he joined Laval University where he is Full Professor in the department of Molecular Biology, Medical Biochemistry and Pathology. He currently holds the Canada Research Chair in Chromatin Biology and Molecular Epigenetics. His research projects characterize the dynamic role of chromatin in the regulation of nuclear functions and cell proliferation. His work uses the yeast model system as well as human cells to define the structure, function and regulation of histone modifying complexes implicated in genome expression and maintenance. Research in his laboratory led to important discoveries on the regulatory mechanisms involved in gene transcription and the cellular response to DNA damage, using expertise in molecular biology and genetics, biochemistry, epigenetics, genomics, proteomics and genome editing.

The Côté lab research aim is to understand chromatin dynamics associated with gene regulation, DNA repair and replication. They study protein complexes that control acetylation and methylation of histones, and the composition of chromatin. They dissect the molecular mechanisms of epigenetics, in which signals to chromatin mark different genomic loci and are read by effectors to translate a biological response. Their work has characterized the structure and function of several protein complexes, identifying their intrinsic recognition modules for the epigenetic histone signature. Discoveries in the laboratory identified and extensively characterized the highly conserved NuA4/Tip60 acetyltransferase complex and demonstrated for the first time the essential role of chromatin modifying activities in the process of DNA repair and replication in eukaryotes. Accurate writing and reading of these epigenetic marks lead to changes in chromatin dynamics, in a targeted manner within the genome, and this process is subverted in cancer. In fact, the clear majority of the activities studied in the Côté lab are tumor suppressors and Tip60 itself is down-regulated in a very large spectrum of cancers.

L'Hôtel-Dieu de Québec
9, rue McMahon
2784-2
Québec, Québec
Canada G1R 2J6
137 entries « 1 of 14 »

Sudarshan D, Avvakumov N, Lalonde ME, Alerasool N, Joly-Beauparlant C, Jacquet K, Mameri A, Lambert JP, Rousseau J, Lachance C, Paquet E, Herrmann L, Thonta Setty S, Loehr J, Bernardini MQ, Rouzbahman M, Gingras AC, Coulombe B, Droit A, Taipale M, Doyon Y, Côté J

Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci

Journal Article

Genes Dev, 2022.

Abstract | Links:

Vann KR, Acharya A, Jang SM, Lachance C, Zandian M, Holt TA, Smith AL, Pandey K, Durden DL, El-Gamal D, Côté J, Byrareddy SN, Kutateladze TG

Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection

Journal Article

Structure, 2022.

Abstract | Links:

Devoucoux M, Fort V, Khelifi G, Xu J, Alerasool N, Galloy M, Wong N, Bourriquen G, Fradet-Turcotte A, Taipale M, Hope K, Hussein SMI, Côté J

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes

Journal Article

Cell Rep, 39 (11), 2022.

Abstract | Links:

Devoucoux M, Roques C, Lachance C, Lashgari A, Joly-Beauparlant C, Jacquet K, Alerasool N, Prudente A, Taipale M, Droit A, Lambert JP, Hussein SMI, Côté J

MRG proteins are shared by multiple protein complexes with distinct functions

Journal Article

Mol Cell Proteomics, 2022.

Abstract | Links:

Lashgari A, Kougnassoukou Tchara PE, Lambert JP, Côté J

New insights into the DNA repair pathway choice with NuA4/TIP60

Journal Article

DNA Repair (Amst), 113 , 2022.

Abstract | Links:

Barry RM, Sacco O, Mameri A, Stojaspal M, Kartsonis W, Shah P, De Ioannes P, Hofr C, Côté J, Sfeir A

Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states

Journal Article

Genes Dev, 36 (5-6), 2022.

Abstract | Links:

Bieluszewski T, Sura W, Dziegielewski W, Bieluszewska A, Lachance C, Kabza M, Szymanska-Lejman M, Abram M, Wlodzimierz P, De Winne N, De Jaeger G, Sadowski J, Côté J, Ziolkowski PA

NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis

Journal Article

Nat Commun, 13 (1), 2022.

Abstract | Links:

Galloy M, Lachance C, Cheng X, Distéfano-Gagné F, Côté J, Fradet-Turcotte A

Approaches to Study Native Chromatin-Modifying Complex Activities and Functions

Journal Article

Front Cell Dev Biol, 9 , 2021.

Abstract | Links:

Ahmad S, Côté V, Côté J

DNA Damage-Induced Phosphorylation of Histone H2A at Serine 15 Is Linked to DNA End Resection

Journal Article

Mol Cell Biol, 41 (12), 2021.

Abstract | Links:

Ahmad S, Côté V, Cheng X, Bourriquen G, Sapountzi V, Altaf M, Côté J

Antagonistic relationship of NuA4 with the non-homologous end-joining machinery at DNA damage sites

Journal Article

PLoS Genet, 17 (9), 2021.

Abstract | Links:

137 entries « 1 of 14 »
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Active projects

  • Control of Genome Expression and Maintenance by MYST-ING Tumor Suppressor Complexes., from 2015-07-01 to 2022-06-30
  • Defining nucleosome features regulating the function of chromatin modifiers and remodelers, from 2022-04-01 to 2027-03-31
  • Functional analysis of the NuA4/TIP60 complex in epigenetic mechanisms linked to genome expression and stability, from 2022-03-01 to 2027-03-31
  • Gene Application to engage a Model Organism Researcher – ING3, from 2021-09-01 to 2022-08-31
  • Plateforme de culture cellulaire pour l'analyse fonctionnelle de modificateurs épigénétiques liés aux maladies humaines, from 2022-04-01 to 2023-09-28
  • Tetrahymena thermophila - un model évolutionnaire divergent pour découvrir de nouveau modes de régulation transcriptionnelle, from 2022-03-15 to 2025-03-14

Recently finished projects

  • Chaire de recherche du Canada en biologie de la chromatine et épigénétique moléculaire, from 2015-01-01 to 2021-12-31
Data provided by the Université Laval research projects registery