Dr. Jacques Corbeil focuses on using the latest techniques in bioinformatics and machine learning to assist and facilitate the processes of diagnosis and prognosis determination and to optimize response to treatment. Modern genomic techniques generate a deluge of data that needs to be interpreted using novel bioinformatic approaches. Dr. Corbeil uses state-of-the-art instrumentation and big data analytics to facilitate the interpretation of complex phenotypic data. His research includes investigating how infectious microorganisms interact with their hosts, examining the effects of antibiotics on our microbial flora, exploring how to design small molecules and drugs to interfere with specific microbial functions and integrating omic data in cancer research. Dr. Corbeil operates at the interface of computer and omic sciences.

Dr. Corbeil completed his undergraduate work at Laval University. He obtained his Ph.D. from the University of New South Wales, Sydney, Australia, and received postdoctoral training at the University of California San Diego; continuing on as a faculty member and rising to the rank of Associate Professor until his return to Canada as holder of the Tier 1 Canada Research Chair in Medical Genomics.

CHUL
2705, boulevard Laurier
R-0709
Québec, Québec
Canada G1V 4G2
158 entries « 1 of 16 »

Kpanou R, Dallaire P, Rousseau E, Corbeil J

Learning self-supervised molecular representations for drug-drug interaction prediction

Journal Article

BMC Bioinformatics, 25 (1), 2024.

Abstract | Links:

Desjardins LC, Brière F, Tremblay AJ, Rancourt-Bouchard M, Drouin-Chartier JP, Corbeil J, Lemelin V, Charest A, Schaefer EJ, Lamarche B, Couture P

Substitution of dietary monounsaturated fatty acids from olive oil for saturated fatty acids from lard increases low-density lipoprotein apolipoprotein B-100 fractional catabolic rate in subjects with dyslipidemia associated with insulin resistance: a randomized controlled trial

Journal Article

Am J Clin Nutr, 2024.

Abstract | Links:

Dzieciolowska S, Charest H, Roy T, Fafard J, Carazo S, Levade I, Longtin J, Parkes L, Beaulac SN, Villeneuve J, Savard P, Corbeil J, De Serres G, Longtin Y

Timing and Predictors of Loss of Infectivity Among Healthcare Workers With Mild Primary and Recurrent COVID-19: A Prospective Observational Cohort Study

Journal Article

Clin Infect Dis, 78 (3), 2024.

Abstract | Links:

Zeng Y, Song Y, Cui L, Wu Q, Wang C, Coelho AC, Zhang G, Wei D, Li C, Zhang J, Corbeil J, Li Y, Feng J

Phylogenomic insights into evolutionary trajectories of multidrug resistant S. pneumoniae CC271 over a period of 14 years in China

Journal Article

Genome Med, 15 (1), 2023.

Abstract | Links:

Brochu E, Huletsky A, Boudreau DK, Raymond F, Bérubé È, Ouameur AA, Frenette J, Boissinot M, Corbeil J, Bergeron MG

Characterization of vancomycin-resistance vanD gene clusters in the human intestinal microbiota by metagenomics and culture-enriched metagenomics

Journal Article

JAC Antimicrob Resist, 5 (2), 2023.

Abstract | Links:

Maltais-Payette I, Vijay J, Simon MM, Corbeil J, Brière F, Grundberg E, Tchernof A

Large-scale analysis of circulating glutamate and adipose gene expression in relation to abdominal obesity

Journal Article

Amino Acids, 54 (9), 2022.

Abstract | Links:

Gobeil É, Maltais-Payette I, Taba N, Brière F, Ghodsian N, Abner E, Bourgault J, Gagnon E, Manikpurage HD, Couture C, Mitchell PL, Mathieu P, Julien F, Corbeil J, Vohl MC, Thériault S, Esko T, Tchernof A, Arsenault BJ

Mendelian Randomization Analysis Identifies Blood Tyrosine Levels as a Biomarker of Non-Alcoholic Fatty Liver Disease

Journal Article

Metabolites, 12 (5), 2022.

Abstract | Links:

Déraspe M, Boisvert S, Laviolette F, Roy PH, Corbeil J

Flexible protein database based on amino acid k-mers

Journal Article

Sci Rep, 12 (1), 2022.

Abstract | Links:

Racine É, Boivin G, Longtin Y, McCormack D, Decaluwe H, Savard P, Cheng MP, Hamelin MÈ, Carbonneau J, Tadount F, Adams K, Bourdin B, Nantel S, Gilca V, Corbeil J, De Serres G, Quach-Thanh C

The REinfection in COVID-19 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workers

Journal Article

Influenza Other Respir Viruses, 16 (5), 2022.

Abstract | Links:

Uyar O, Dominguez JM, Bordeleau M, Lapeyre L, Ibáñez FG, Vallières L, Tremblay ME, Corbeil J, Boivin G

Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response

Journal Article

J Neuroinflammation, 19 (1), 2022.

Abstract | Links:

158 entries « 1 of 16 »
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Active projects

  • Antimicrobial resistance genes in bioaerosols in Canadian arctic, rural, and urban environments: sources, profiles, transport and fate, from 2019-12-01 to 2025-11-30
  • Chaire de recherche du Canada en Medical genomics, from 2018-01-01 to 2024-12-31
  • Deciphering breast cancer HER2-negativity with regard to HER2-targeted therapy, from 2016-07-01 to 2025-03-31
  • Development of an advanced multiplexed lab-on-a-chip system for highthroughput screening using organ-on-a-chip technology to support Al drug discovery, from 2024-03-01 to 2025-02-28
  • Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.3, from 2019-11-01 to 2024-10-31
  • Ecogenomics of mining areas for sustainable Canadian North (GENOSCAN), from 2020-11-01 to 2024-12-31
  • Exploration multi-omique des biopsies liquides pour dépister les porteurs de bactéries pathogènes et leurs résistances, from 2023-04-24 to 2024-04-23
  • Extreme zooming on intestinal permeability and the western-style diet: Unravelling the role of dietary antigens on the prevalence of cardiometabolic and mental health diseases in the North, from 2020-11-01 to 2024-12-31
  • Identification of innate immune pathways as targets for immunomodulatory therapy in herpes simplex virus encephalitis, from 2023-10-01 to 2028-09-30
  • L'empreinte métabolomique plasmatique des produits laitiers: un reflet de leur consommation et une fenêtre sur leurs effets cardiométaboliques, from 2023-01-01 to 2025-09-03
  • PandemicStop-AI: for an accelerated response to pandemics, from 2024-03-01 to 2028-03-31
  • PandemicStop-AI: for an accelerated response to pandemics, from 2024-03-01 to 2028-03-31
  • Unravelling the impact of diet on cardiovascular health in heterozygous familial hypercholesterolemia: a metabolomic approach, from 2021-10-01 to 2025-09-30
  • Validation de la mesure d’expression génique unicellulaire à partir d’un échantillon de tissu hépatique chez des sujets avec une suspicion clinique de stéatose hépatique non-alcoolique., from 2022-08-24 to 2025-03-31

Recently finished projects

  • Acides biliaires et maladies inflammatoires chroniques de l’intestin : et si la solution était dans l’assiette?, from 2022-03-03 to 2023-03-02
  • COVID19 persistent symptomatology: an investigation of the metabolomic and proteomic underpinning, from 2021-06-01 to 2022-05-31
  • Déterminer la qualité de la polypharmacie chez les aînés : une approche basée sur l’intelligence artificielle, from 2020-04-01 to 2023-03-31
  • Développement d'une technologie de contrôle de la qualité des plantes en cours du procédé manufacturier de médicaments en utilisant la spectrométrie de masse à haut débit couplée à des approches en apprentissage automatique , from 2020-03-19 to 2023-03-31
  • MAchine learning for diGItal diagnosTICS of antimicrobial resistance, from 2019-10-01 to 2022-09-30
  • Observatoire international sur les impacts sociétaux de l'intelligence artificielle et du numérique, from 2018-04-01 to 2024-03-31
  • Prédire l'évolution de l'hépatite C par la fédération de données et l'intelligence artificielle : enjeux éthiques, juridiques, sociaux et de vie privée, from 2019-04-01 to 2024-03-31
  • Rôle des habitudes de vie sur le microbiote et la réponse clinique à l’immunothérapie en cancer de la vessie, from 2023-04-20 to 2024-03-31
  • UVILUQ: l'utilisation des biopsie liquides pour le monitoring de l'état de santé des écosystèmes marins côtiers, from 2020-07-01 to 2023-06-30
  • Validation des marqueurs cellulaires ChromaLive sur modèles d'organopuces, from 2022-12-12 to 2023-08-23
Data provided by the Université Laval research projects registery