Dr. Isabelle Marc is a clinician researcher at the Research Centre of the CHU de Québec, and an associate professor at the Department of Pediatrics at Laval University. She has built her research environment around her clinical practice as a pediatrician. Dr. Marc works on the effects of maternal life habits (exercise, sleep, breastfeeding) on child growth and development. Several of her studies have been realised with her students in cohorts in which she is involved. She developed an exercise laboratory for pregnant women and children at the Research Centre, which allows her to collect objective measurements of this population’s physical condition.

Dr. Marc is interested in the effects of omega-3 on the neonatal morbidity of extremely premature infants (less than 28 weeks of gestation). A supplementation with omega-3 administered to the lactating mother is an effective way to provide a daily dose of omega-3 to the preterm child through breast milk. She now wants to demonstrate the positive effects of this intervention on the infant’s health, growth, and development.

Maternal omega-3 supplementation to reduce bronchopulmonary dysplasia in very preterm infants: A randomized controlled trial (MOBYDIck Trial)
This multicenter clinical trial, funded by the CIHR, is performed in collaboration with researchers from 18 Canadian neonatal level III intensive care units. Bronchopulmonary dysplasia (BPD) is defined as the need for ventilatory support/oxygen at 36 weeks of postmenstrual age. It is the most common and severe neonatal complication of extremely premature infants, but current approaches for the treatment and prevention are limited. After birth, breast milk becomes a source of omega-3 for preterm infants. The MOBYDIck Trial will evaluate the efficiency of maternal supplementation with omega-3 during lactation 1) to reduce the prevalence of BPD or it’s severity for the preterm infants and 2) to improve the neuro-development of the child at 2 years of age.

Sino-Canada HeLTI: A multifaceted community-family-mother-child intervention study for the prevention of childhood obesity
Obesity and its related metabolic syndrome disorders are a major public health concern. Increasing evidence points to the role of early life adverse factors in the developmental origins of the vulnerability to such metabolic disorders. Reducing the risk of overweight and obesity (OWO) from early life stages will produce substantial benefits to decrease population burdens of metabolic diseases. Dr. Marc is part of a research team in Canada and China that collaborates to identify the mechanisms that may underline the development of OWO, and the impacts of a community-family-mother-child intervention on OWO in children aged 5 years old in China.

3D cohort (Découvrir, Développer, Devenir) and the transition project of the Integrated Research Network in Perinatology of Quebec and Eastern Ontario (IRNPQEO)
The 3D cohort is following more than 2 300 families in the province of Quebec from pregnancy to childhood. The Integrated Research Network in Perinatology of Quebec and Eastern Ontario is a research team interested in the effects of various adverse prenatal risk factors (life habits, social, behavioral, environmental, and genetic) on the pregnancy, on the health of the mother and the father, and on infant development. The IRNPQEO will transfer much needed new knowledge to legislators, policy makers, clinicians, and consumers.

CHUL
2705, boulevard Laurier
T3-08
Québec, Québec
Canada G1V 4G2
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Dugas C, Brassard D, Bélanger M, Perron J, Weisnagel SJ, Marc I, Robitaille J

Determinants of Healthy Diet Among Children Exposed and Unexposed to Gestational Diabetes

Journal Article

J Nutr Educ Behav, 54 (5), 2022.

Abstract | Links:

Ndiaye ABKT, Mohamed I, Pronovost E, Angoa G, Piedboeuf B, Lemyre B, Afifi J, Qureshi M, Sériès T, Guillot M, Simonyan D, Yusuf K, Lavoie PM, Fraser WD, Mâsse B, Nuyt AM, Lacaze-Masmonteil T, Marc I

Use of SMOF lipid emulsion in very preterm infants does not affect the incidence of bronchopulmonary dysplasia-free survival

Journal Article

JPEN J Parenter Enteral Nutr, 46 (8), 2022.

Abstract | Links:

Angoa G, Pronovost E, Ndiaye ABKT, Lavoie PM, Lemyre B, Mohamed I, Simonyan D, Qureshi M, Afifi J, Yusuf K, Sériès T, Guillot M, Piedboeuf B, Fraser WD, Nuyt AM, Mâsse B, Lacaze-Masmonteil T, Marc I

Effect of Maternal Docosahexaenoic Acid Supplementation on Very Preterm Infant Growth: Secondary Outcome of a Randomized Clinical Trial

Journal Article

Neonatology, 119 (3), 2022.

Abstract | Links:

Guillot M, Robitaille CA, Turner L, Pronovost E, Caouette G, Matte-Gagné C, Olivier F, Bartholomew J, Massé É, Morin A, Mohamed I, Marc I

Effects of maternal docosahexaenoic acid supplementation on brain development and neurodevelopmental outcomes of breastfed preterm neonates: protocol for a follow-up at preschool age of a randomised clinical trial (MOBYDIckPS)

Journal Article

BMJ Open, 12 (5), 2022.

Abstract | Links:

Guillot M, Synnes A, Pronovost E, Qureshi M, Daboval T, Caouette G, Olivier F, Bartholomew J, Mohamed I, Massé E, Afifi J, Hendson L, Lemyre B, Luu TM, Strueby L, Cieslak Z, Yusuf K, Pelligra G, Ducruet T, Ndiaye ABKT, Angoa G, Sériès T, Piedboeuf B, Nuyt AM, Fraser W, Mâsse B, Lacaze-Masmonteil T, Lavoie PM, Marc I

Maternal High-Dose DHA Supplementation and Neurodevelopment at 18-22 Months of Preterm Children

Journal Article

Pediatrics, 150 (1), 2022.

Abstract | Links:

Hao Y, Wang L, Wang C, Peng A, Gao W, Marc I, Semenic S, Fraser WD, Narayan A, Wu Y, Chang S, Huang H

Breastfeeding Practices and Associated Factors in Shanghai: A Cross-Sectional Study

Journal Article

Nutrients, 14 (20), 2022.

Abstract | Links:

Marc I, Boutin A, Pronovost E, Guillot M, Bergeron F, Moore L, Makrides M

High doses of enteral docosahexaenoic acid omega-3 supplementation for prevention of bronchopulmonary dysplasia in very preterm infants: a protocol for a systematic review and meta-analysis

Journal Article

BMJ Open, 12 (10), 2022.

Abstract | Links:

Rioux C, Parent S, Castellanos-Ryan N, Archambault I, Boivin M, Herba CM, Lupien SJ, Marc I, Muckle G, Fraser WD, Séguin JR

The 3D-Transition Study: Objectives, Methods, and Implementation of an Innovative Planned Missing-Data Design

Journal Article

Am J Epidemiol, 190 (11), 2021.

Abstract | Links:

Wu Y, Marc I, Bouchard L, Ouyang F, Luo ZC, Fan J, Dubois L, Masse B, Zhang J, Leung PCK, Liao XP, Herba CM, Booij L, Shen J, Lewin A, Jiang H, Wang L, Xu J, Wu W, Sun W, Wu J, Li H, Lei C, Kozyrskyj A, Semenic S, Chaillet N, Fortier I, Masse L, Zhan J, Allard C, Knoppers B, Zawati M, Baillargeon JP, Velez MP, Zhang H, Yu Y, Yu W, Ding Y, Vaillancourt C, Liu H, Tetu A, Fang W, Zhang R, Zhao X, Jin Y, Liu XM, Chen Z, Yang X, Hao YH, Abdelouahab N, Fraser W, Huang HF

Study protocol for the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI): a multicentre, cluster-randomised, parallel-group, superiority trial of a multifaceted community-family-mother-child intervention to prevent childhood overweight and obesity

Journal Article

BMJ Open, 11 (4), 2021.

Abstract | Links:

Wu Y, Ma X, Fraser WD, Li M, Wang W, Huang H, Landry M, Hao Y, Liu H, Semenic S, Zhang Y, Wang H, Zhang J, Yu J, La X, Zhang C, Marc I, Jiang H

Caregivers' perceptions, challenges and service needs related to tackling childhood overweight and obesity: a qualitative study in three districts of Shanghai, China

Journal Article

BMC Public Health, 21 (1), 2021.

Abstract | Links:

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Active projects

  • Empowering Next-generation Researchers in perinatal and Child Health (ENRICH), from 2022-01-01 to 2027-12-31
  • HeLTI cooperative research project: A Multifaceted Maternal-Child Health Intervention Cohort Study for the prevention of childhood obesity, from 2022-02-01 to 2027-01-31
  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, from 2017-04-01 to 2025-03-31
  • Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants : A Randomized controlled trial (MOBYDIck trial)., from 2014-07-01 to 2025-03-31
  • Maternal sleep-disordered breathing during pregnancy and long-term health outcomes in children: the 3D pregnancy and birth cohort, from 2019-04-01 to 2024-09-30
  • Usage du cannabis et ses effets sur le déroulement et l'issue de la grossesse, la santé et le développement de l'enfant d'âge préscolaire, from 2023-04-01 to 2028-03-31

Recently finished projects

  • Dysplasie bronchopulmonaire et profil neurodéveloppemental à 2 ans, from 2022-10-12 to 2023-03-31
  • Évaluation de la mesure de capacité cardiorespiratoire chez les enfants d’âge scolaire:étude de faisabilité, from 2023-09-08 to 2024-03-31
  • Pediatric Outcomes imProvement through COordination of Research Networks (POPCORN), from 2022-03-01 to 2024-02-29
Data provided by the Université Laval research projects registery