Dr. François Marceau has been studying bradykinin receptors for over 30 years, their regulation, ligands and functions. Notably, as early as in the 1980s, the regulation of B1 receptor expression by cytokines and immunopathology was highlighted, with work replicated and expanded around the world. He has been part of an international committee on the nomenclature of bradykinin receptors, leading to a review article cited over 800 times, of which he is a co-author (Pharmacol Rev. 2005; 57: 27). More recently, two subjects have caught the attention of the laboratory, i.e. the creation of bifunctional biotechnological ligands for peptide hormone receptors, including those of bradykinin, and the angioedema states, presently the main clinical application of bradykinin. Dr. Marceau has been, and is, regularly invited as a speaker at specialized conferences.
2705, boulevard Laurier
Canada G1V 4G2
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Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulationJournal Article
Int Immunopharmacol, 82 , 2020.
The development of a targeted and more potent, anti-Inflammatory derivative of colchicine: Implications for goutJournal Article
Biochem Pharmacol, 180 , 2020.
Bradykinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology DatabaseJournal Article
IUPHAR BPS Guide Pharm CITE, 2019 (4), 2019.
Increased fibrinolysis-induced bradykinin formation in hereditary angioedema confirmed using stored plasma and biotechnological inhibitorsJournal Article
BMC Res Notes, 12 (1), 2019.
Comparing Pathways of Bradykinin Formation in Whole Blood From Healthy Volunteers and Patients With Hereditary Angioedema Due to C1 Inhibitor DeficiencyJournal Article
Front Immunol, 9 , 2018.
D-Arg-Bradykinin-Arg-Arg, a Latent Vasoactive Bradykinin B Receptor Agonist Metabolically Activated by CarboxypeptidasesJournal Article
Front Pharmacol, 9 , 2018.
Reprint of: Editorial: Correspondence from Chirumbolo and BjorklundJournal Article
Int Immunopharmacol, 62 , 2018.
Editorial: Correspondence from Chirumbolo and BjorklundJournal Article
Int Immunopharmacol, 55 , 2018.
Bifunctional ligands of the bradykinin B and B receptors: An exercise in peptide hormone plasticityJournal Article
Peptides, 105 , 2018.
Bifunctional fusion proteins containing the sequence of the bradykinin homologue maximakinin: activities at the rat bradykinin B receptorJournal Article
Can J Physiol Pharmacol, 96 (5), 2018.
- Séquençage du génome et signature biologique pour le diagnostic de l'héréditaire C1-inh-normal, from 2022-09-01 to 2024-09-30
Recently finished projects
- Mesures des kinines et de leurs métabolites dans le sang des patients atteints de diverses formes d'angio-oedème héréditaire (AOH) , from 2021-08-30 to 2022-03-31