Dr. François Marceau has been studying bradykinin receptors for over 30 years, their regulation, ligands and functions. Notably, as early as in the 1980s, the regulation of B1 receptor expression by cytokines and immunopathology was highlighted, with work replicated and expanded around the world. He has been part of an international committee on the nomenclature of bradykinin receptors, leading to a review article cited over 800 times, of which he is a co-author (Pharmacol Rev. 2005; 57: 27). More recently, two subjects have caught the attention of the laboratory, i.e. the creation of bifunctional biotechnological ligands for peptide hormone receptors, including those of bradykinin, and the angioedema states, presently the main clinical application of bradykinin. Dr. Marceau has been, and is, regularly invited as a speaker at specialized conferences.

CHUL
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46155
+1 418-654-2765
Francois.Marceau@crchudeq...

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201 entries « ‹ 2 of 21 › »

Marceau F, Bachelard H, Bouthillier J, Fortin JP, Morissette G, Bawolak MT, Charest-Morin X, Gera L

Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulation

Journal Article

Int Immunopharmacol, 82 , 2020.

Abstract | Links:

Pare G, Vitry J, Marceau F, Vaillancourt M, Winter P, Bachelard H, Naccache PH, Tuszynski JA, Fernandes MJ

The development of a targeted and more potent, anti-Inflammatory derivative of colchicine: Implications for gout

Journal Article

Biochem Pharmacol, 180 , 2020.

Abstract | Links:

Coulson J, Couture R, Faussner A, Gobeil F Jr, Leeb-Lundberg F, Marceau F, Muller-Esterl W, Pettibone D, Zuraw B

Bradykinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Journal Article

IUPHAR BPS Guide Pharm CITE, 2019 (4), 2019.

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Marceau F, Bachelard H, Rivard GE, Hebert J

Increased fibrinolysis-induced bradykinin formation in hereditary angioedema confirmed using stored plasma and biotechnological inhibitors

Journal Article

BMC Res Notes, 12 (1), 2019.

Abstract | Links:

Charest-Morin X, Hebert J, Rivard GE, Bonnefoy A, Wagner E, Marceau F

Comparing Pathways of Bradykinin Formation in Whole Blood From Healthy Volunteers and Patients With Hereditary Angioedema Due to C1 Inhibitor Deficiency

Journal Article

Front Immunol, 9 , 2018.

Abstract | Links:

Bachelard H, Charest-Morin X, Marceau F

D-Arg-Bradykinin-Arg-Arg, a Latent Vasoactive Bradykinin B Receptor Agonist Metabolically Activated by Carboxypeptidases

Journal Article

Front Pharmacol, 9 , 2018.

Abstract | Links:

Marceau F

Reprint of: Editorial: Correspondence from Chirumbolo and Bjorklund

Journal Article

Int Immunopharmacol, 62 , 2018.

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Marceau F

Editorial: Correspondence from Chirumbolo and Bjorklund

Journal Article

Int Immunopharmacol, 55 , 2018.

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Marceau F, Bawolak MT, Fortin JP, Morissette G, Roy C, Bachelard H, Gera L, Charest-Morin X

Bifunctional ligands of the bradykinin B and B receptors: An exercise in peptide hormone plasticity

Journal Article

Peptides, 105 , 2018.

Abstract | Links:

Charest-Morin X, Lodge R, Marceau F

Bifunctional fusion proteins containing the sequence of the bradykinin homologue maximakinin: activities at the rat bradykinin B receptor

Journal Article

Can J Physiol Pharmacol, 96 (5), 2018.

Abstract | Links:

201 entries « ‹ 2 of 21 › »
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Active projects

  • Séquençage du génome et signature biologique pour le diagnostic de l'héréditaire C1-inh-normal, from 2022-09-01 to 2024-09-30

Recently finished projects

  • Mesures des kinines et de leurs métabolites dans le sang des patients atteints de diverses formes d'angio-oedème héréditaire (AOH) , from 2021-08-30 to 2022-03-31
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