Dr. François Marceau has been studying bradykinin receptors for over 30 years, their regulation, ligands and functions. Notably, as early as in the 1980s, the regulation of B1 receptor expression by cytokines and immunopathology was highlighted, with work replicated and expanded around the world. He has been part of an international committee on the nomenclature of bradykinin receptors, leading to a review article cited over 800 times, of which he is a co-author (Pharmacol Rev. 2005; 57: 27). More recently, two subjects have caught the attention of the laboratory, i.e. the creation of bifunctional biotechnological ligands for peptide hormone receptors, including those of bradykinin, and the angioedema states, presently the main clinical application of bradykinin. Dr. Marceau has been, and is, regularly invited as a speaker at specialized conferences.
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
Latest news
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C5a receptor antagonism coming of age for vascular pathology
Journal ArticleInt Immunopharmacol, 110 , 2022.
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Are noscapine and raloxifene ligands of the bradykinin B2 receptor? An assessment based on the human umbilical vein contractility assay
Journal ArticleInt Immunopharmacol, 110 , 2022.
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Picomolar Sensitivity Analysis of Multiple Bradykinin-Related Peptides in the Blood Plasma of Patients With Hereditary Angioedema in Remission: A Pilot Study
Journal ArticleFront Allergy, 3 , 2022.
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In vitro pharmacological profile of PHA-022121, a small molecule bradykinin B2 receptor antagonist in clinical development
Journal ArticleInt Immunopharmacol, 105 , 2022.
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Bradykinin receptors in GtoPdb v.2021.3
Journal ArticleIUPHAR BPS Guide Pharm CITE, 2021 (3), 2021.
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A Robust Bioassay of the Human Bradykinin B Receptor that Extends Molecular and Cellular Studies: The Isolated Umbilical Vein
Journal ArticlePharmaceuticals (Basel), 14 (3), 2021.
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Covid-19 challenges to immune investigations and therapies
Journal ArticleInt Immunopharmacol, 95 , 2021.
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In Vitro Modeling of Bradykinin-Mediated Angioedema States
Journal ArticlePharmaceuticals (Basel), 13 (9), 2020.
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Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants
Journal ArticleFront Med (Lausanne), 7 , 2020.
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In Vitro Pharmacological Profile of a New Small Molecule Bradykinin B2 Receptor Antagonist
Journal ArticleFront Pharmacol, 11 , 2020.
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Recently finished projects
- Caractérisation du système kallikréine-kinines chez les familles de patients atteints d'angio-œdème héréditaire avec niveau normal de " C1-esterase inhibitor", from 2019-05-31 to 2021-03-31
- Mesures des kinines et de leurs métabolites dans le sang des patients atteints de diverses formes d'angio-oedème héréditaire (AOH) , from 2021-08-30 to 2022-03-31