Dr. François Gros-Louis is a regular researcher at the CHU Research Center of Québec-Laval University and Professor in the Department of Surgery of the School of Medicine at Laval University. Dr. Gros-Louis’ research activities are grouped together at the Multidisciplinary Center for Tissue Engineering (LOEX), a research center dedicated to organogenesis, stem cells, regenerative medicine and to the reconstruction of living human tissues and organs through tissue engineering. He holds the Canada Research Chair in Biomodeling and Treatment of Brain Diseases, and is the co-director of the induced pluripotent stem cell platform (iPSC).

Several neurological conditions such as neurodegenerative diseases and other brain diseases occupy a prominent place because of their severity and increasing frequency related to the aging of the population. One of the major obstacles to understanding the development of these diseases is the accessibility of neuronal tissues. Dr. Gros-Louis’ research, at the crossroads between basic research and clinical research, is positioned in a fast-growing research field that aims to reconstruct human tissue through tissue engineering, using patient-derived tissue, to model and better understand the pathophysiological mechanisms underlying these diseases. The main objective of his research program is to reconstruct by tissue engineering, from the patient’s own cells, organs / organoids (skins and blood vessels) whose histological, physiological and functional properties make it possible to reproduce the pathological signatures of various brain diseases (Amyotrophic Lateral Sclerosis (ALS), intracranial aneurysm and neurofibromatosis). The specific objectives are: 1) to identify new strategies for early diagnosis, 2) to study and monitor the progression of targeted diseases, 3) to evaluate the response to existing and future treatments, 4) to identify and understand pathogenic mechanisms, and 5) to identify specific biomarkers and to develop new therapeutic pathways. Dr. Gros-Louis has played a major role in the discovery and application of a novel method for the in vitro reconstruction of tissue, through tissue engineering, for the study of ALS, neurofibromatosis, and intracranial aneurysms.

1401, 18e Rue
LOEX / CMDGT
R-211
Québec, Québec
Canada G1J 1Z4
+1 418-525-4444, extension 61708
francois.gros-louis@crchu... francois.gros-louis@fmed....

Latest news

48 entries « ‹ 5 of 5 › »

Millecamps S, Gentil BJ, Gros-Louis F, Rouleau G, Julien JP

Alsin is partially associated with centrosome in human cells

Journal Article

Biochim Biophys Acta, 1745 (1), 2005.

Abstract | Links:

Gros-Louis F, Larivière R, Gowing G, Laurent S, Camu W, Bouchard JP, Meininger V, Rouleau GA, Julien JP

A frameshift deletion in peripherin gene associated with amyotrophic lateral sclerosis

Journal Article

J Biol Chem, 279 (44), 2004.

Abstract | Links:

Valdmanis PN, Simoes Lopes AA, Gros-Louis F, Stewart JD, Rouleau GA, Dupre N

A novel neurodegenerative disease characterised by posterior column ataxia and pyramidal tract involvement maps to chromosome 8p12-8q12.1

Journal Article

J Med Genet, 41 (8), 2004.

| Links:

Gros-Louis F, Laurent S, Lopes AA, Khoris J, Meininger V, Camu W, Rouleau GA

Absence of mutations in the hypoxia response element of VEGF in ALS

Journal Article

Muscle Nerve, 28 (6), 2003.

| Links:

Hand CK, Devon RS, Gros-Louis F, Rochefort D, Khoris J, Meininger V, Bouchard JP, Camu W, Hayden MR, Rouleau GA

Mutation screening of the ALS2 gene in sporadic and familial amyotrophic lateral sclerosis

Journal Article

Arch Neurol, 60 (12), 2003.

Abstract | Links:

Gros-Louis F, Meijer IA, Hand CK, Dube MP, MacGregor DL, Seni MH, Devon RS, Hayden MR, Andermann F, Andermann E, Rouleau GA

An ALS2 gene mutation causes hereditary spastic paraplegia in a Pakistani kindred

Journal Article

Ann Neurol, 53 (1), 2003.

| Links:

Hand CK, Khoris J, Salachas F, Gros-Louis F, Lopes AA, Mayeux-Portas V, Brewer CG, Brown Jr, Meininger V, Camu W, Rouleau GA

A novel locus for familial amyotrophic lateral sclerosis, on chromosome 18q

Journal Article

Am J Hum Genet, 70 (1), 2002.

Abstract | Links:

Krabchi K, Gros-Louis F, Yan J, Bronsard M, Masse J, Forest JC, Drouin R

Quantification of all fetal nucleated cells in maternal blood between the 18th and 22nd weeks of pregnancy using molecular cytogenetic techniques

Journal Article

Clin Genet, 60 (2), 2001.

Abstract | Links:

48 entries « ‹ 5 of 5 › »
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Active projects

  • Chaire de recherche du Canada en génie tissulaire et modélisation 3D des maladies du cerveau, from 2023-05-01 to 2030-04-30
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of dermal fibroblasts in the establishment of microenvironment favouring NF1-associated skin tumor formation using personalized tissue-engineered 3D models, from 2023-10-01 to 2028-09-30
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models, from 2023-03-01 to 2024-02-29
  • Génie tissulaire et modélisation 3D des maladies du cerveau, from 2023-04-01 to 2024-03-31
  • Organogenèse de muqueuse nasale autologue pour la reconstruction endoscopique endonasale en chirurgie de la base du crâne, from 2023-10-01 to 2028-09-30

Recently finished projects

  • Chaire de recherche du Canada en biomodélisation et traitement des maladies du cerveau, from 2017-11-01 to 2022-10-31
  • Chaire de recherche sur les organes reconstruits en laboratoire et leurs applications cliniques, from 2013-05-01 to 2023-12-01
  • Conversion directe de fibroblastes en cellules de Schwann pour stimuler la réparation des nerfs périphériques, from 2022-04-01 to 2023-03-31
  • Creating an Open Science Repository of ARCA1 iPSCs, from 2021-05-31 to 2023-05-31
  • Design and testing of a next-generation tissue-engineered living human heart valve, from 2020-03-31 to 2023-03-31
  • Les cellules souches pluripotentes génétiquement corrigées comme thérapie pour l’epidermolyse bulleuse simplex, from 2022-04-01 to 2023-03-31
  • Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, from 2017-04-01 to 2022-03-31
  • Renforcement de la plateforme de production de cellules souches induites à la pluripotence (IPSC) du CRCHU de Québec, from 2019-12-05 to 2023-03-31
Data provided by the Université Laval research projects registery